Optical mapping of the Mycobacterium avium subspecies paratuberculosis genome [PDF]
Abstract Background Infection of cattle with Mycobacterium avium subspecies paratuberculosis (M. ap) causes severe economic losses to the dairy industry in the USA and worldwide. In an effort to better examine diversity among M. ap strains, we used optical mapping to profile genomic variations between strains of M. ap
Schwartz David C +4 more
openaire +3 more sources
Killing of Mycobacterium avium subspecies paratuberculosis within macrophages [PDF]
Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis) is a facultative intracellular pathogen that resides within host macrophages during infection of ruminant animals. We examined survival of M. paratuberculosis infections within cultured macrophages to better understand the interplay between bacterium and host.Serial plating of M ...
Bannantine, John P., Stabel, Judith R.
openaire +3 more sources
On the effect of thalidomide on Mycobacterium avium subspecies paratuberculosis in culture [PDF]
Without known mechanisms of action, thalidomide is used to treat a variety of non-malignant 'idiopathic' diseases. There is increasing concern that Mycobacterium avium subspecies paratuberculosis (MAP) may be zoonotic. Recently, methotrexate, azathioprine, 6-mercaptopurine (6-MP), 5-aminosalicylic acid (5-ASA), cyclosporine A, rapamycin, and tacrolimus
Greenstein, Robert J. +2 more
openaire +2 more sources
Diagnostic Sequences That Distinguish M. avium Subspecies Strains
Over a decade ago Mycobacterium avium subspecies paratuberculosis (Map) specific genes were initially identified in a whole genome context by comparing draft genome sequences of Map strain K-10 with Mycobacterium avium subspecies hominissuis (Mah) strain
John P. Bannantine +4 more
doaj +1 more source
Paratuberculosis is a chronic infection of the intestine, mainly the ileum, caused by Mycobacterium avium subsp. paratuberculosis in cattle and other ruminants.
Cyril Conde +10 more
doaj +1 more source
STUDIES ON MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS ISOLATED FROM SOME EGYPTIAN DAIRY FARMS [PDF]
The current study was carried out on three Egyptian dairy herds located at Alexandria, Ismailia and Mansoura, from 2009 to 2012. Those herds were suffering from clinical or subclinical infection of Mycobacterium avium subspecies paratuberculosis (MAP ...
ABDEL MOGHNEY, A.F. +2 more
doaj +1 more source
Mycobacterium avium subspecies paratuberculosis: A possible causative agent in human morbidity and risk to public health safety [PDF]
Mycobacterium avium subspecies paratuberculosis is a bacterial parasite and the causative agent of paratuberculosis, a disease predominately found in cattle and sheep.
Mary Garvey
doaj +1 more source
A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis. [PDF]
BACKGROUND: Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes.
Hermon-Taylor, J +11 more
core +1 more source
Exploring the Zoonotic Potential of Mycobacterium avium Subspecies paratuberculosis through Comparative Genomics. [PDF]
A comparative genomics approach was utilised to compare the genomes of Mycobacterium avium subspecies paratuberculosis (MAP) isolated from early onset paediatric Crohn's disease (CD) patients as well as Johne's diseased animals.
Michalski Wojtek P. +32 more
core +1 more source
Paratuberculosis is a chronic, progressive enteritis of ruminants, caused by Mycobacterium avium subspecies paratuberculosis. It affects the productivity of infected dairy cows, causing a reduction in the daily milk yield and basic milk components.
Agnieszka Wiszniewska-Łaszczych +3 more
doaj +1 more source

