Results 191 to 200 of about 462,704 (302)

AI‐Assisted SERS in Bacterial Diagnosis and Antimicrobial Susceptibility Testing: Advances, Gaps, and Translational Pathways

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
This review examines recent advances in integrating artificial intelligence (AI) with surface‐enhanced Raman spectroscopy (SERS) for the detection of pathogenic bacteria and evaluation of drug resistance phenotypes. Key challenges in clinical translation are critically discussed, along with prospective solutions and future research directions ...
Chen Liu, Yu Liu, Junlu Wang, Yujie Liu, Qijia Zhan, Jiangang Liu, Ruoping Chen, Kun Zhang   +7 more
wiley   +1 more source

Machine learning-based analysis of drug resistance mutations in Mycobacterium tuberculosis. [PDF]

PLoS One
Thankamani A, C L B, Doss C GP.
europepmc   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Upregulation of CREB1 by Mycobacterium Tuberculosis Transcriptionally Activates TREM2 to Promote Macrophage M2 Polarization. [PDF]

Cell Biochem Funct
Zhu Y, Xu M, Liu D, Ning W, Wang M, Huang F, An Z, Qiu J, Tang X, Wang P, Tian B, Wen L.   +11 more
europepmc   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Genome-wide transcriptional landscape of <i>Mycobacterium tuberculosis</i> during acute lung infection. [PDF]

Front Immunol
Bhargavi G, Ghanny S, Soteropoulous P, Vetrivel U, Jayaraman R, Subbian S.   +5 more
europepmc   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Mycobacterium tuberculosis VadK is required for the regulation of the methylcitrate cycle and virulence. [PDF]

EMBO Rep
Pascoe J, Newcombe J, Mendoza J, Birua S, Mendum TA, Anand K, Singh A, Sinha A, Papavinasasundaram K, Bhatt A, Larrouy-Maumus G, Singh A, Goulding CW, Beste DJV.   +13 more
europepmc   +1 more source

From Identification to Enzymatic Activity Profiling: Comprehensive Characterization of BloCAβ, a Probiotic β‐Carbonic Anhydrase From Bifidobacterium longum

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Production and biochemical characterization of a new β‐carbonic anhydrase from the probiotic Bifidobacterium longum, one of the main players of human gut microbiota. ABSTRACT The microbiota comprises communities of microorganisms that establish complex relationships with the host and play key roles in physiology, metabolism, and immunity.
Simone Giovannuzzi, Andrea Ammara, Simone Carradori, Viviana De Luca, Marialucia Gallorini, Damiano Iacovozzi, Amelia Cataldi, Ilaria D'Agostino, Davide Moi, Valentina Onnis, Claudiu T. Supuran, Clemente Capasso   +11 more
wiley   +1 more source