Results 1 to 10 of about 24,385 (265)

Low-Frequency Raman Spectroscopy of Pure and Cocrystallized Mycophenolic Acid [PDF]

Pharmaceutics, 2023
The aqueous solubility of solid-state pharmaceuticals can often be enhanced by cocrystallization with a coformer to create a binary cocrystal with preferred physical properties.
Catherine S. Wallace, Margaret P. Davis, Timothy M. Korter   +2 more
doaj   +2 more sources

Volumetric Absorptive Microsampling of Saliva for Pharmacokinetic Evaluation of Mycophenolic Acid and Its Glucuronide Metabolite in Pediatric Renal Transplant Recipients: Bioanalytical Method Validation and Clinical Feasibility Evaluation [PDF]

Pharmaceuticals
Background: Mycophenolic acid (MPA) is frequently used in pediatric renal transplantation as part of immunosuppressive therapy, yet therapeutic drug monitoring (TDM) remains challenging.
Arkadiusz Kocur, Joanna Sobiak, Agnieszka Czajkowska, Jacek Rubik, Tomasz Pawiński   +4 more
doaj   +2 more sources

The Roche Total Mycophenolic Acid® assay: An application protocol for the ABX Pentra 400 analyzer and comparison with LC–MS in children with idiopathic nephrotic syndrome

Practical Laboratory Medicine, 2017
Background: For TDM of mycophenolate acid (MPA), the Roche Total Mycophenolic Acid® assay based on the inhibition of recombinant inosine monophosphate dehydrogenase (IMPDH) has been shown to be a simple and reliable alternative to chromatographic methods.
François Parant, Bruno Ranchin, Marie-Claude Gagnieu   +2 more
doaj   +2 more sources

Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report

Clinical Case Reports, 2022
Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea.
Ryota Tanaka, Asami Matsumoto, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Hiromitsu Mimata, Hiroki Itoh   +6 more
doaj   +2 more sources

Stability of Mycophenolic Acid and Mycophenolic Acid Glucuronide in Human Plasma [PDF]

Clinical Chemistry, 1999
Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is being used increasingly in immunosuppressant therapy after solid organ transplantation (1)(2)(3). Its immunosuppressive activity is thought to reside in the inhibition of inosine monophosphate dehydrogenase (IMPDH), leading to a suppression of purine nucleotide synthesis ...
M, Shipkova, V W, Armstrong, T, Schneider, P D, Niedmann, E, Schütz, E, Wieland, M, Oellerich   +6 more
openaire   +3 more sources

Usefulness of monitoring mycophenolic acid exposure in systemic sclerosis-related interstitial lung disease: a retrospective cohort study. [PDF]

BMC Pulm Med
Milesi J, Sampol E, Benyamine A, Diai S, Coiffard B, Nieves A, Granel B, Reynaud-Gaubert M, Bermudez J.   +8 more
europepmc   +3 more sources

Structural basis for substrate flexibility of the O-methyltransferase MpaG' involved in mycophenolic acid biosynthesis. [PDF]

Protein Sci
You C, Pan Y, Liu R, Li S, Feng Y.
europepmc   +3 more sources

Physicochemical Characterization and In Vitro Activity of Poly(ε-Caprolactone)/Mycophenolic Acid Amorphous Solid Dispersions. [PDF]

Polymers (Basel)
Sánchez-Aguinagalde O, Sanchez-Rexach E, Polo Y, Larrañaga A, Lejardi A, Meaurio E, Sarasua JR.   +6 more
europepmc   +3 more sources

Influence of mycophenolate mofetil dosage and plasma levels on the occurrence of chronic lung allograft dysfunction in lung transplants: a retrospective cohort analysis

Swiss Medical Weekly, 2022
INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite ...
Carolin Steinack, Philipp Saurer, Fiorenza Gautschi, René Hage, Gernot Ortmanns, Macé M. Schuurmans, Thomas Gaisl   +6 more
doaj   +1 more source

Evaluating the antibody response to SARS-COV-2 vaccination amongst kidney transplant recipients at a single nephrology centre.

PLoS ONE, 2022
Background and objectivesKidney transplant recipients are highly vulnerable to the serious complications of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infections and thus stand to benefit from vaccination.
Chukwuma A Chukwu, Kassir Mahmood, Safa Elmakki, Julie Gorton, Phillip A Kalra, Dimitrios Poulikakos, Rachel Middleton   +6 more
doaj   +2 more sources