Results 1 to 10 of about 21,722 (233)

Low-Frequency Raman Spectroscopy of Pure and Cocrystallized Mycophenolic Acid [PDF]

Pharmaceutics, 2023
The aqueous solubility of solid-state pharmaceuticals can often be enhanced by cocrystallization with a coformer to create a binary cocrystal with preferred physical properties.
Catherine S. Wallace, Margaret P. Davis, Timothy M. Korter   +2 more
doaj   +2 more sources

Volumetric Absorptive Microsampling of Saliva for Pharmacokinetic Evaluation of Mycophenolic Acid and Its Glucuronide Metabolite in Pediatric Renal Transplant Recipients: Bioanalytical Method Validation and Clinical Feasibility Evaluation [PDF]

Pharmaceuticals
Background: Mycophenolic acid (MPA) is frequently used in pediatric renal transplantation as part of immunosuppressive therapy, yet therapeutic drug monitoring (TDM) remains challenging.
Arkadiusz Kocur, Joanna Sobiak, Agnieszka Czajkowska, Jacek Rubik, Tomasz Pawiński   +4 more
doaj   +2 more sources

Influence of mycophenolate mofetil dosage and plasma levels on the occurrence of chronic lung allograft dysfunction in lung transplants: a retrospective cohort analysis

Swiss Medical Weekly, 2022
INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite ...
Carolin Steinack, Philipp Saurer, Fiorenza Gautschi, René Hage, Gernot Ortmanns, Macé M. Schuurmans, Thomas Gaisl   +6 more
doaj   +1 more source

Evaluating the antibody response to SARS-COV-2 vaccination amongst kidney transplant recipients at a single nephrology centre.

PLoS ONE, 2022
Background and objectivesKidney transplant recipients are highly vulnerable to the serious complications of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infections and thus stand to benefit from vaccination.
Chukwuma A Chukwu, Kassir Mahmood, Safa Elmakki, Julie Gorton, Phillip A Kalra, Dimitrios Poulikakos, Rachel Middleton   +6 more
doaj   +2 more sources

Humoral response to SARS-CoV-2 mRNA vaccination in previous non-responder kidney transplant recipients after short-term withdrawal of mycophenolic acid

Frontiers in Medicine, 2022
Seroconversion rates after COVID-19 vaccination are significantly lower in kidney transplant recipients compared to healthy cohorts. Adaptive immunization strategies are needed to protect these patients from COVID-19.
Louise Benning, Christian Morath, Tessa Kühn, Marie Bartenschlager, Heeyoung Kim, Jörg Beimler, Mirabel Buylaert, Christian Nusshag, Florian Kälble, Marvin Reineke, Maximilian Töllner, Matthias Schaier, Katrin Klein, Antje Blank, Antje Blank, Paul Schnitzler, Martin Zeier, Caner Süsal, Ralf Bartenschlager, Ralf Bartenschlager, Ralf Bartenschlager, Thuong Hien Tran, Claudius Speer, Claudius Speer   +23 more
doaj   +1 more source

Therapeutic monitoring of mycophenolic acid in renal transplanted patients by a validated HPLC method [PDF]

Folia Medica, 2021
Introduction: Mycophenolate mofetil and its active metabolite mycophenolic acid are routinely used as immunosuppressant drugs in solid organ transplantation in a fixed daily dose regimen in association with cyclosporine, tacrolimus and steroids ...
Mikaela Kolaci, Leonard Deda, Alma Idrizi, Myftar Barbullushi, Dariel Thereska   +4 more
doaj   +3 more sources

Analysis of mycophenolic acid from saliva samples after its purification with the method of solidliquid extraction [PDF]

Arhiv za farmaciju, 2014
Pharmacological effect of a drug depends on its free fraction in plasma. By certain drugs, like immunosupresive mycophenolic acid, concentrations below therapeutic lead to rejection of the transplanted organ while concentrations above therapeutic lead to
Otašević Biljana, Protić Ana, Golubović Jelena, Zečević Mira, Cerović Milica, Bralović Ljubica   +5 more
doaj   +1 more source

Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. [PDF]

PLoS ONE, 2013
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants.
Ana M Ortega-Prieto, Julie Sheldon, Ana Grande-Pérez, Héctor Tejero, Josep Gregori, Josep Quer, Juan I Esteban, Esteban Domingo, Celia Perales   +8 more
doaj   +1 more source

Simple and Sensitive High-Performance Liquid Chromatography (HPLC) Method with UV Detection for Mycophenolic Acid Assay in Human Plasma. Application to a Bioequivalence Study [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: A simple and available reversed-phase high performance liquid chromatography (HPLC) method with UV detection has been developed and validated for mycophenolic acid (MPA) assay in human plasma.
Hossein Danafar, Mehrdad Hamidi
doaj   +1 more source

Mitomycin, 5-fluorouracil, leflunomide, and mycophenolic acid directly promote hepatitis B virus replication and expression in vitro

Virology Journal, 2020
Background Reactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy.
Jie Ruan, Shuo Sun, Xin Cheng, Pengyu Han, Yinge Zhang, Dianxing Sun   +5 more
doaj   +1 more source