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Treatment Of Psoriasis With Oral Mycophenolic Acid [PDF]
Journal of Investigative Dermatology, 1975 Mycophenolic acid (MPA), an inhibitor of purine synthesis, was evaluated for its therapeutic and adverse effects in 29 patients with psoriasis. MPA was administered orally for at least 12 weeks, during which time the daily dose was increased from 1600 to 4800 mg depending on occurrence of adverse reactions.
Warren W. Epinette +4 more
core +5 more sources
Frontiers in Medicine, 2022 Seroconversion rates after COVID-19 vaccination are significantly lower in kidney transplant recipients compared to healthy cohorts. Adaptive immunization strategies are needed to protect these patients from COVID-19.
Louise Benning +23 more
doaj +2 more sources
Influence of mycophenolate mofetil dosage and plasma levels on the occurrence of chronic lung allograft dysfunction in lung transplants: a retrospective cohort analysis [PDF]
Swiss Medical Weekly, 2022 INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite ...
Carolin Steinack +6 more
doaj +2 more sources
Low-Frequency Raman Spectroscopy of Pure and Cocrystallized Mycophenolic Acid [PDF]
Pharmaceutics, 2023 The aqueous solubility of solid-state pharmaceuticals can often be enhanced by cocrystallization with a coformer to create a binary cocrystal with preferred physical properties.
Catherine S. Wallace +2 more
doaj +2 more sources
Mycophenolic Acid in Silage [PDF]
Applied and Environmental Microbiology, 2000 ABSTRACT We examined 233 silage samples and found that molds were present in 206 samples with counts between 1 × 10 3 and 8.9 × 10 7 (mean, 4.7 × 10 6 ) CFU/g. Mycophenolic acid, a metabolite of Penicillium roqueforti , was detected by
Isabell Schneweis +3 more
openaire +4 more sources
Virology Journal, 2020 Background Reactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy.
Jie Ruan +5 more
doaj +2 more sources
Voclosporin: a novel calcineurin inhibitor with no impact on mycophenolic acid levels in patients with SLE. [PDF]
Nephrol Dial Transplant, 2022 Background An open-label phase 1 study was conducted to evaluate the effect of voclosporin following dosing with mycophenolate mofetil (MMF) on blood levels of mycophenolic acid (MPA, the active moiety of MMF) and MPA glucuronide (MPAG, the ...
van Gelder T +3 more
europepmc +2 more sources
Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats
Frontiers in Bioengineering and Biotechnology, 2020 The present study explores the influence of mycophenolic acid (MPA) in combination therapy with quercetin (QC) (impeding MPA metabolic rate) delivered using the liposomal nanoparticles (LNPs).
Gopal Patel +8 more
doaj +2 more sources
Communications Biology, 2021 Guste Urbonaite and Jimmy Tsz Hang Lee et al. present a droplet-based single-cell sequencing method optimized for use in yeast. They use their method—yeastDropSeq—to investigate the changes in gene expression profiles following treatment with the ...
Guste Urbonaite +5 more
doaj +2 more sources
Compartmentalized biosynthesis of mycophenolic acid [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Here, we elucidate the full biosynthetic pathway of the fungal natural product mycophenolic acid (MPA). Besides the intriguing enzymatic mechanisms, we reveal that the MPA biosynthetic enzymes are elegantly compartmentalized; the oxygenase MpaB′ is the long-sought enzyme responsible for initiating the oxidative cleavage of the ...
Fengwei Li +20 more
openaire +6 more sources