Results 141 to 150 of about 4,993,363 (331)
Linguistic mechanism of the evolution of amino acid frequencies and genomic GC content [PDF]
arXiv, 2006 Much information is stored in amino acid composition of protein and base composition of DNA. We simulated the evolution of amino acid frequencies and genomic GC content by a linguistic model. It is showed that the evolution of genetic code determines the evolution of amino acid frequencies and genomic GC content.
arxiv
Clinical pharmacology in drug development, 2016 This report summarizes phase 1 studies that evaluated pharmacokinetic interactions between the novel triazole antifungal agent isavuconazole and the immunosuppressants cyclosporine, mycophenolic acid, prednisolone, sirolimus, and tacrolimus in healthy ...
A. Groll +12 more
semanticscholar +1 more source
Adaptive evolution of drug targets in producer and non-producer organisms [PDF]
, 2012 Mycophenolic acid (MPA) is an immunosuppressive drug produced by several fungi in Penicillium subgenus Penicillium. This toxic metabolite is an inhibitor of IMP dehydrogenase (IMPDH). The MPA biosynthetic cluster of P.
Balzarini +40 more
core +1 more source
Arthritis &Rheumatology, Volume 77, Issue 5, Page 571-581, May 2025.Objective Two randomized trials for patients with diffuse systemic sclerosis (SSc) demonstrated an overall survival (OS) and event‐free survival (EFS) advantage of autologous hematopoietic stem cell transplantation (AHSCT) using CD34+ selected peripheral blood stem cells (PBSCs) compared with monthly cyclophosphamide (CY).
George E. Georges +16 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2019 Mycophenolic acid (MPA, 1) and its derivatives are first-line immunosuppressants used in organ transplantation and for treating autoimmune diseases. Despite chemical synthetic achievements, the biosynthetic formation of a seven-carbon carboxylic acid ...
Xiwei Chen +6 more
doaj
Genetic Code Table: A note on the three splittings into amino acid classes [PDF]
arXiv, 2009 This note represents the further progress in understanding the determination of the genetic code by Golden mean (Rakocevic, 1998). Three classes of amino acids that follow from this determination (the 7 "golden" amino acids, 7 of their complements, and 6 non-complements) are observed now together with two further possible splittings into 4 x 5 and 5 x ...
arxiv
Respirology Case Reports, Volume 13, Issue 5, May 2025.We present the case of an ANCA+ EGPA patient with a long disease history and remission for over 8 years (between 2015 and 2023), who developed a life‐threatening relapse marked by diffuse alveolar haemorrhage and mononeuritis multiplex despite low‐dose mepolizumab (100 mg q4w) maintenance therapy.
Aurelie Vanthuyne +2 more
wiley +1 more source
De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans.
PLoS Pathogens, 2012 We have investigated the potential of the GTP synthesis pathways as chemotherapeutic targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal meningoencephalitis.
Carl A Morrow +11 more
doaj +1 more source
Development of Ethosomes Containing Mycophenolic Acid
Procedia Chemistry, 2012 AbstractMycophenolic acid (MPA) is mainly considered an immunosuppressive drug because it is an inhibitor of inosine monophosphate dehydrogenase (IMPDH), and selectively inhibits T- and B-cell proliferation. The aim of this study was to develop the ethosome containing MPA to enhance skin permeation after topical administration for the enhancement of ...
Tunyaluk Limsuwan, Thanaporn Amnuaikit
openaire +2 more sources
The effect of mycophenolic acid on the growth of Staphylococcus aureus in heart broth [PDF]
, 1945 E. P. Abraham
openalex +1 more source