Determination of mycophenolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry [PDF]
Journal of Pharmaceutical Analysis, 2014 A simple, sensitive and high throughput ultra performance liquid chromatography tandem mass spectrometry method has been developed for the determination of mycophenolic acid in human plasma.
Vivek Upadhyay +4 more
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Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. [PDF]
PLoS ONE, 2013 Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants.
Ana M Ortega-Prieto +8 more
doaj +5 more sources
Titer improvement of mycophenolic acid in the novel producer strain Penicillium arizonense and expression analysis of its biosynthetic genes [PDF]
BMC Microbiology, 2023 Mycophenolic acid (MPA) is the active ingredient in the most important immunosuppressive pharmaceuticals. It has antifungal, antibacterial, antiviral, anti-psoriasis, and antitumor activities.
Hala A. Ammar +3 more
doaj +2 more sources
Mycophenolic acid induces senescence of vascular precursor cells. [PDF]
PLoS ONE, 2018 OBJECTIVE:Endothelial dysfunction is central to the pathogenesis of many rheumatic diseases, typified by vascular inflammation and damage. Immunosuppressive drugs induce disease remission and lead to improved patient survival.
Ellen Go +9 more
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Antiviral and Cytotoxic Effects of Mycophenolic Acid
Journal of General Virology, 1969 Mycophenolic acid, produced by various species of the genus Penicillium, has been shown to have both antibacterial and antifungal properties (see Korzybski, Kowszyk-Gindifer & Kurylowicz 1967). Mycophenolic acid was found to be antiviral in tissue culture. The Agar Diffusion Test (Herrmann et al. 1960) was employed, using 100 µg. per well.
D. N. Planterose
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Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report [PDF]
Clinical Case Reports, 2022 Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea.
Ryota Tanaka +6 more
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Methodical approaches to bioassay of substances containing unstable functional groups [PDF]
Research Results in Pharmacology, 2018 Introduction: This article describes the method development approaches for bioassay of substances containing unstable functional groups and forming unstable metabolites using the example of mycophenolic acid, methyldopa and mebeverine metabolites.
Alexander L. Khokhlov +4 more
doaj +7 more sources
Mycophenolic Acid Is a Potent Inhibitor of Angiogenesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Angiogenesis is necessary for the vascularization of a tumor, providing essential nourishment for tumor growth, and the progression and metastasis of cancer cells.1 Although tremendous efforts and resources have been dedicated to discovering angiogenesis inhibitors, very few candidates have been approved by FDA for therapeutic applications. Currently,
Zhen Yang +5 more
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Clinical pharmacology and therapy, 2023 Despite (repeated) boosting, kidney transplant recipients (KTRs) may remain at increased risk of severe COVID‐19 since a substantial number of individuals remain seronegative or with low antibody titers.
S. Meziyerh +8 more
semanticscholar +1 more source
PLoS ONE, 2022 Background and objectives Kidney transplant recipients are highly vulnerable to the serious complications of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infections and thus stand to benefit from vaccination. Therefore, it is necessary to
Chukwuma A. Chukwu +6 more
doaj +2 more sources