Results 11 to 20 of about 14,175 (232)
Stability of Mycophenolic Acid and Mycophenolic Acid Glucuronide in Human Plasma [PDF]
Clinical Chemistry, 1999 Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is being used increasingly in immunosuppressant therapy after solid organ transplantation (1)(2)(3). Its immunosuppressive activity is thought to reside in the inhibition of inosine monophosphate dehydrogenase (IMPDH), leading to a suppression of purine nucleotide synthesis ...
Tanja Schneider +6 more
openaire +3 more sources
Hepatology, EarlyView., 2022 In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole +12 more
wiley +1 more source
Hepatology Communications, EarlyView., 2022 Abstract Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network ...
Jennifer Jo +19 more
wiley +1 more source
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. [PDF]
PLoS ONE, 2013 Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants.
Ana M Ortega-Prieto +8 more
doaj +1 more source
Simple and Sensitive High-Performance Liquid Chromatography (HPLC) Method with UV Detection for Mycophenolic Acid Assay in Human Plasma. Application to a Bioequivalence Study [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: A simple and available reversed-phase high performance liquid chromatography (HPLC) method with UV detection has been developed and validated for mycophenolic acid (MPA) assay in human plasma.
Hossein Danafar, Mehrdad Hamidi
doaj +1 more source
Mycophenolate-induced eosinophilic colitis: A case report
Iatreia, 2023 Mycophenolate mofetil is a medication used for the prevention of allograft rejection in organ transplant patients. Eosinophilic colitis due to mycophenolate is a recognized condition in patients with a history of renal transplantation and persistent ...
Mario Alberto Caviedes-Cleves +1 more
doaj +1 more source
Virology Journal, 2020 Background Reactivation of hepatitis B virus is a common complication that occurs in patients with hepatitis B virus (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy.
Jie Ruan +5 more
doaj +1 more source
Frontiers in Public Health, 2021 Background: Organ transplantations are difficult, complicated and very expensive interventions. In order to preserve the transplanted organs, it is necessary to provide medical care to the patients in terms of immunosuppression.
Majda Sahman +5 more
doaj +1 more source
Compartmentalized biosynthesis of mycophenolic acid [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Here, we elucidate the full biosynthetic pathway of the fungal natural product mycophenolic acid (MPA). Besides the intriguing enzymatic mechanisms, we reveal that the MPA biosynthetic enzymes are elegantly compartmentalized; the oxygenase MpaB′ is the long-sought enzyme responsible for initiating the oxidative cleavage of the ...
Fengwei Li +20 more
openaire +5 more sources
Refractory neuro-Sweet disease successfully treated with tocilizumab and mycophenolate mofetil [PDF]
Encephalitis, 2021 Sweet syndrome, or acute febrile neutrophilic dermatosis, is mainly a dermatologic condition presenting with erythematous plaques; however, neutrophils infiltrate multiple systems. Neuro-Sweet disease is a neurological manifestation of Sweet syndrome and
Sungeun Hwang +7 more
doaj +1 more source