Results 201 to 210 of about 14,175 (232)

Crystal structure of mycophenolic acid

Journal of the Chemical Society, Perkin Transactions 2, 1972
Crystals of the title compound, are triclinic, a= 9·555(2), b= 11·639(3), c= 7·341(3)A, α= 90·75(10), β= 90·77(5), γ= 102·70(2)°, Z= 2, space group P. The structure was determined from diffractometer data by direct methods, and was refined by full-matrix least-squares techniques to R 0·076 for 1548 observed reflexions.
J. Trotter, H. M. M. Shearer, W. Harrison   +2 more
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Halogenated analogues of mycophenolic acid

Journal of the Chemical Society, Chemical Communications, 1973
Halogenated analogues of mycophenolic acid (I) were produced by cultures of Penicillium brevicompactum fed respectively with 4-bromo-5,7-dihydroxy-phthalide (V) and 4-chloro-5,7-dihydroxyphthalide (VI).
Renato Craveri, Carlo Scolastico, Fabrizio Aragozzini, Bruno Rindone, Luigi Canonica   +4 more
openaire   +2 more sources

Total synthesis of mycophenolic acid

Tetrahedron, 2003
Abstract A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step.
Adrián Covarrubias-Zúñiga, Armando González-Lucas, Mireya M. Domı́nguez   +2 more
openaire   +2 more sources

Mycophenolic acid as a latent agonist of PPARγ

Bioorganic & Medicinal Chemistry Letters, 2007
Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated ...
Mie Tsuruga, Nobuyasu Matsuura, Keiko Taki, Shinya Mitsuhashi, Hitomi Takamori, Kaoru Yamashita, Noriyuki Nakajima, Misaki Ohashi, Makoto Ubukata, Junji Magae, Tomohisa Asada   +10 more
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Pharmacokinetics of Mycophenolic Acid in Renal Insufficiency

Therapeutic Drug Monitoring, 2000
Mycophenolate mofetil (MMF) is now widely used in solid organ transplantation. MMF is rapidly converted to its active form, mycophenolic acid (MPA), upon reaching the systemic circulation. MPA is metabolized to its glucuronide metabolite, mycophenolic acid glucuronide (MPAG), by glucoronyl transferases in the liver and possibly elsewhere.
Leslie M. Shaw, Herwig Ulf Meier-Kriesche, Bruce Kaplan, Magdalena Korecka   +3 more
openaire   +2 more sources

Mechanisms of Action of Mycophenolic Acid

Annals of the New York Academy of Sciences, 1993
Anthony C. Allison, Elsie M. Eugui, W. Joseph Kowalski, Christian D. Muller   +3 more
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Mycophenolic acid and mycophenolic acid glucuronide trough levels after renal transplantation

Transplantation Proceedings, 1997
R. Pichlmayr, M. Behrend, R. Lueck
openaire   +3 more sources

A total synthesis of mycophenolic acid

Tetrahedron Letters, 1971
L. Canonica, B. Rindone, E. Santaniello, C. Scolastico   +3 more
openaire   +2 more sources

Nucleic Acid Tests for Clinical Translation

Chemical Reviews, 2021
Min Li, Lu Song, Xiuhai Mao
exaly  

Accurate Estimation of Mycophenolic Acid AUC

Therapeutic Drug Monitoring, 2001
Taylor, P. J., Willis, C., Salm, P., Tett, S. E., Pillans, P. I.   +4 more
openaire   +4 more sources