Results 281 to 290 of about 4,993,363 (331)

Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage

Toxicology Mechanisms and Methods, 2022
The gastrointestinal side effects of mycophenolic acid affect its efficacy in kidney transplant patients, which may be due to its toxicity to the intestinal epithelial mechanical barrier, including intestinal epithelial cell apoptosis and destruction of ...
Yi-yun Deng, Zhe Zhang, Yu-Ting Hong, Lijuan Feng, Yong Su, Dujuan Xu   +5 more
semanticscholar   +1 more source

Synergistic Regulation of Metabolism by Ca2+/Reactive Oxygen Species in Penicillium brevicompactum Improves Production of Mycophenolic Acid and Investigation of the Ca2+ Channel.

ACS Synthetic Biology, 2021
Although Penicillium brevicompactum is a very important industrial strain for mycophenolic acid production, there are no reports on Ca2+/reactive oxygen species (ROS) synergistic regulation and calcium channels, Cch-pb.
Mianhui Chen, Jingjing Wang, Lin Lin, Xiang-yang Xu, Wei Wei, Yaling Shen, D. Wei   +6 more
semanticscholar   +1 more source

Biosynthesis of mycophenolic acid

Journal of the Chemical Society, Perkin Transactions 1, 1972
Incorporation experiments with labelled potential biosynthetic intermediates suggest that the methyl group at C-4 of the phthalide system in mycophenolic acid is introduced at the tetraketide stage. This then gives way to the aromatic system, which is further oxidised to 5,7-dihydroxy-4-methylphthalide.
L. Canonica, W. Kroszczynski, B. M. Ranzi, B. Rindone, E. Santaniello, C. Scolastico   +5 more
openaire   +4 more sources

Mycophenolic acid in psoriasis

British Journal of Dermatology, 2006
Mycophenolic acid (MPA) is a fermentation product of a penicillium mould which has shown antitumour acitivity in certain animal models. It blocks nucleic acid synthesis by interfering with the interconversions of inosine monophosphate (IMP), xanthine monophosphate (XMP) and guanine monophosphate (GMP) thereby inhibiting growth and/or replication of ...
Charles J. McDonald, Alicja Rudnicka, Stanley Spatz   +2 more
openaire   +3 more sources

Mycophenolic Acid for Psoriasis

Archives of Dermatology, 1977
Mycophenolic acid is an antimetabolite used experimentally for the treatment of psoriasis. Thirty-eight patients were treated with mycophenolic acid. A double-blind, placebo-controlled study demonstrated the efficacy of mycophenolic acid (P less than .01).
William S. Lynch, Henry H. Roenigk
openaire   +3 more sources

A short overview on mycophenolic acid pharmacology and pharmacokinetics.

Clinical Transplantation, 2020
Immunosuppressive therapy is used in solid organ transplant treatment, and mycophenolic acid (MPA) is one of the immunosuppressive drugs most used worldwide.
P. L. Ferreira, F. Thiesen, A. G. Pereira, A. Zimmer, P. Fröehlich   +4 more
semanticscholar   +1 more source

The biosynthesis of mycophenolic acid

Journal of the Chemical Society D: Chemical Communications, 1970
The biosynthesis of mycophenolic acid (I) in Penicillium brevi-compactum occurs through introduction and a subsequent partial removal of a farnesyl side-chain into 5,7-dihydroxy-4-methylphthalide (II); the methyl group of (II) is introduced prior to the formation of the aromatic system.
W. Kroszczynski, B. M. Ranzi, B. Rindone, Carlo Scolastico, L. Canonica   +4 more
openaire   +2 more sources

Mycophenolate Acid vs Mycophenolate Mofetil Therapy

Transplantation Proceedings, 2010
Mycophenolate mofetil (MMF) is included in the basic immunosuppression regimen in heart transplantation (HTx). Classically, the mycophenolic acid (MPA) concentration has not been considered to provide clinical information.To perform a comparative analysis of MMF dosage and MPA concentration and their effect on post-HTx renal function.Sixty patients ...
Luis Martínez-Dolz, L. Almenar, Manuel Portolés, Esther Rosello, Miguel Rivera, Antonio Salvador, Ignacio Sánchez-Lázaro   +6 more
openaire   +2 more sources

Mycophenolic Acid for Lymphomatoid Papulosis

Journal of Cutaneous Medicine and Surgery, 2013
Background: Lymphomatoid papulosis is a rare CD30+ lymphoproliferative T-cell disorder with limited effective treatments. Objective: We describe the case of a 50-year-old woman diagnosed with lymphomatoid papulosis who was unable to access phototherapy and who failed to clear while on systemic treatment with methotrexate.
Trevor Champagne, Scott Walsh
openaire   +3 more sources

Mycophenolic acid in marketed cheeses

Food and Cosmetics Toxicology, 1979
Analysis of a total of 100 samples of blue-moulded cheese showed that 38 contained mycophenolic acid, three at levels higher than 10 ppm. This contamination is particularly frequent in some types of cheese, and is due to the use, in their manufacture, of those Penicillum roqueforti strains that produce a high yield of mycophenolic acid in vitro.
J. Lafont, M.G. Siriwardana, I. Combemale, P. Lafont   +3 more
openaire   +3 more sources