Results 21 to 30 of about 4,993,363 (331)
Therapeutic monitoring of mycophenolic acid in renal transplanted patients by a validated HPLC method [PDF]
Folia Medica, 2021 Introduction: Mycophenolate mofetil and its active metabolite mycophenolic acid are routinely used as immunosuppressant drugs in solid organ transplantation in a fixed daily dose regimen in association with cyclosporine, tacrolimus and steroids ...
Mikaela Kolaci +4 more
doaj +3 more sources
Analysis of mycophenolic acid from saliva samples after its purification with the method of solidliquid extraction [PDF]
Arhiv za farmaciju, 2014 Pharmacological effect of a drug depends on its free fraction in plasma. By certain drugs, like immunosupresive mycophenolic acid, concentrations below therapeutic lead to rejection of the transplanted organ while concentrations above therapeutic lead to
Otašević Biljana +5 more
doaj +1 more source
Mycophenolic Acid Exposure Prediction Using Machine Learning
Clinical pharmacology and therapy, 2021 Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well‐established and machine learning (ML) approaches could help to estimate AUC.
J. Woillard +3 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole +12 more
wiley +1 more source
British Journal of Clinical Pharmacology, 2021 Mycophenolic acid (MPA) is an immunosuppressive drug commonly used for prophylaxis of graft rejection in solid organ transplant recipients. The main concern with the prolonged use of immunosuppressive drugs is the risk of developing cancer.
Pannaphak Hirunsatitpron +5 more
semanticscholar +1 more source
Hepatology Communications, EarlyView., 2022 Abstract Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network ...
Jennifer Jo +19 more
wiley +1 more source
Stability of Mycophenolic Acid and Mycophenolic Acid Glucuronide in Human Plasma [PDF]
Clinical Chemistry, 1999 Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is being used increasingly in immunosuppressant therapy after solid organ transplantation (1)(2)(3). Its immunosuppressive activity is thought to reside in the inhibition of inosine monophosphate dehydrogenase (IMPDH), leading to a suppression of purine nucleotide synthesis ...
Tanja Schneider +6 more
openaire +3 more sources
Journal of Clinical Pharmacy and Therapeutics, 2021 Mycophenolate mofetil, an ester prodrug of mycophenolic acid (MPA), is widely used to prevent graft rejection after kidney transplantation. The pharmacokinetic (PK) of MPA has been extensively studied, which revealed a high degree of variability.
Chun-Lan Yang +7 more
semanticscholar +1 more source
Simple and Sensitive High-Performance Liquid Chromatography (HPLC) Method with UV Detection for Mycophenolic Acid Assay in Human Plasma. Application to a Bioequivalence Study [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: A simple and available reversed-phase high performance liquid chromatography (HPLC) method with UV detection has been developed and validated for mycophenolic acid (MPA) assay in human plasma.
Hossein Danafar, Mehrdad Hamidi
doaj +1 more source
Six years of continuous mechanical circulatory support following chronic graft failure
Artificial Organs, Volume 47, Issue 1, Page 214-216, January 2023., 2023 Re‐transplantation is the preferred treatment for patients with chronic heart transplant failure. If re‐transplantation is not a viable option due to the patient's comorbidities, left ventricle assist device can be used as the destination treatment. An interdisciplinary approach with thorough follow‐up can help in the early detection and treatment of ...
Mohamed Ghoneim +3 more
wiley +1 more source