Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]
, 2015 Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W +6 more
core +12 more sources
Mycophenolic acid induces apoptosis of hepatic stellate cells in an in vitro model of HCV
Annals of Hepatology, 2015 Introduction. Hepatitis C virus (HCV) infection is an important risk factor for the development of liver fibrosis and progression to cirrhosis. Liver transplantation as terminal treatment option for liver disease requires life-long immunosuppression ...
Jan Best +10 more
doaj +1 more source
Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats
Frontiers in Bioengineering and Biotechnology, 2020 The present study explores the influence of mycophenolic acid (MPA) in combination therapy with quercetin (QC) (impeding MPA metabolic rate) delivered using the liposomal nanoparticles (LNPs).
Gopal Patel +8 more
doaj +1 more source
Mycophenolic acid induces senescence of vascular precursor cells. [PDF]
PLoS ONE, 2018 OBJECTIVE:Endothelial dysfunction is central to the pathogenesis of many rheumatic diseases, typified by vascular inflammation and damage. Immunosuppressive drugs induce disease remission and lead to improved patient survival.
Ellen Go +9 more
doaj +1 more source
Mycotoxicological monitoring. Part 3. Feedstuffs from raw grain processing
Ветеринария сегодня, 2020 The paper presents the results of mycotoxicological testing of the production batches of sunflower cake and meal, feedstuffs of soybean and wheat bran processing received from domestic processing establishments and livestock farms from 2009 to 2019 ...
G. P. Kononenko +2 more
doaj +1 more source
Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]
, 2014 BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol +5 more
core +5 more sources
The Lancet MicrobeSummary: Background: Pneumocystis pneumonia (PCP) case clusters involving solid organ transplant (SOT) recipients have been reported worldwide. Mycophenolic acid, an immunosuppressant used to prevent rejection in SOT recipients that targets the inosine ...
Claire V Hoffmann, PhD +63 more
doaj +1 more source
Mycophenolic Acid in Silage [PDF]
Applied and Environmental Microbiology, 2000 ABSTRACT We examined 233 silage samples and found that molds were present in 206 samples with counts between 1 × 10 3 and 8.9 × 10 7 (mean, 4.7 × 10 6 ) CFU/g. Mycophenolic acid, a metabolite of Penicillium roqueforti , was detected by
I, Schneweis +3 more
openaire +2 more sources
Compartmentalized biosynthesis of mycophenolic acid [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Here, we elucidate the full biosynthetic pathway of the fungal natural product mycophenolic acid (MPA). Besides the intriguing enzymatic mechanisms, we reveal that the MPA biosynthetic enzymes are elegantly compartmentalized; the oxygenase MpaB′ is the long-sought enzyme responsible for initiating the oxidative cleavage ...
Wei Zhang +16 more
openaire +2 more sources
Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. [PDF]
, 2015 BACKGROUND Mycophenolic acid (MPA) prodrugs are anti-proliferative immunosuppressive agents commonly used after organ transplantation. Although they are generally well tolerated by patients, adverse effects may occur.
Borowiec, Agnieszka +8 more
core +1 more source