Results 41 to 50 of about 14,175 (232)

Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report

Clinical Case Reports, 2022
Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea.
Ryota Tanaka, Asami Matsumoto, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Hiromitsu Mimata, Hiroki Itoh   +6 more
doaj   +1 more source

Electrochemical Biosensor for Rapid Detection of Acute Rejection in Kidney Transplants

Advanced Healthcare Materials, EarlyView.
A low‐cost, rapid electrochemical immunosensor coated with a novel antifouling nanocomposite enables single‐step, dual‐biomarker profiling directly from unprocessed urine. Application in a clinical study shows accurate discrimination of acute rejection in kidney transplants from other acute kidney injuries via machine learning.
Rohit Gupta, Nikolaos Salaris, Ashish Kalkal, Fernando Yuen Chang, Maryam Javed, Azhar Ali Khan, Priya Mandal, Stavroula Balabani, Reza Motallebzadeh, Manish K. Tiwari   +9 more
wiley   +1 more source

Byssochlamys nivea as a Source of Mycophenolic Acid [PDF]

Applied and Environmental Microbiology, 2005
ABSTRACT Byssochlamys species are responsible for spoilage and degradation of fruits and silages and can also produce the mycotoxin patulin. We analyzed secondary metabolite production by Byssochlamys nivea .
Puel, Olivier, Tadrist, Souria, Galtier, Pierre, Oswald, Isabelle P., Delaforge, Marcel   +4 more
openaire   +5 more sources

Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression

Advanced Science, EarlyView.
GLed, a reversible lanthanide‐based GSH sensor that enables real‐time, single‐cell measurement of Gamma–Glutamyl Cysteine Ligase (GCL) activity ‐whose role in human T cells remains unclear‐ is developed. GLed directly links GCL activity to T cell effector functions and reveals its modulation by immunosuppressive drugs, identifying GCL as a critical ...
Francisco Fueyo‐González, Carmen Salto‐Giron, Mehek Ningoo, Laura Espinar‐Barranco, Rafael Salto, Jose Manuel Paredes, Rosario Herranz, Angel Orte, Miguel Fribourg, Juan A. González‐Vera   +9 more
wiley   +1 more source

Successful treatment of HIV‐associated lupus‐like glomerulonephritis with mycophenolic acid

Clinical Case Reports, 2020
HIV‐associated lupus‐like glomerulonephritis is an uncommon but well‐described entity. Treatment has traditionally focused on control of HIV viremia with some using adjuvant steroids.
Mark Tiong, Scott Wilson, Alan Pham, Anastasia Chrysostomou   +3 more
doaj   +1 more source

Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents

Microbiology Spectrum, 2023
Mpox virus (formerly monkeypox virus [MPXV]) is a neglected zoonotic pathogen that caused a worldwide outbreak in May 2022. Given the lack of an established therapy, the development of an anti-MPXV strategy is of vital importance.
Takayuki Hishiki, Takeshi Morita, Daisuke Akazawa, Hirofumi Ohashi, Eun-Sil Park, Michiyo Kataoka, Junki Mifune, Kaho Shionoya, Kana Tsuchimoto, Shinjiro Ojima, Aa Haeruman Azam, Shogo Nakajima, Madoka Kawahara, Tomoki Yoshikawa, Masayuki Shimojima, Kotaro Kiga, Ken Maeda, Tadaki Suzuki, Hideki Ebihara, Yoshimasa Takahashi, Koichi Watashi   +20 more
doaj   +1 more source

IMMUNOSUPPRESSIVE EFFECT OF MYCOPHENOLIC ACID

The Journal of Antibiotics, 1969
The immune response to sheep red blood cells of the mice treated with mycophenolic acid was studied from both humoral and cellular aspects. Mycophenolic acid showed markedly immunosuppressive effect on the antibody formation when mice were treated with daily doses of more than 60mg/kg for 5 consecutive days starting on the day of antigen injection ...
Seikichi Suzuki, Akiko Mitsui
openaire   +4 more sources

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source

Peripheral Blood Gene Expression Profiling and Prognostic Significance for the Course of Interstitial Lung Disease in Patients With Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective We used data from the placebo arm of the Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial to determine the prognostic/predictive significance of peripheral blood cell (PBC) transcript modules for the course of forced vital capacity (FVC) in patients with systemic sclerosis–associated interstitial lung disease (SSc‐ILD ...
Shervin Assassi, Christopher P. Denton, Matthias Zwick, Ramona Schmid, Carina Ittrich, Tobias Litzenburger, Sudha Visvanathan   +6 more
wiley   +1 more source

Methodical approaches to bioassay of substances containing unstable functional groups [PDF]

Research Results in Pharmacology, 2018
Introduction: This article describes the method development approaches for bioassay of substances containing unstable functional groups and forming unstable metabolites using the example of mycophenolic acid, methyldopa and mebeverine metabolites.
Alexander L. Khokhlov, Ilya I. Yaichkov, Yuriy A. Dzhurko, Leonid N. Shitov, Anastasia A. Shitova   +4 more
doaj   +3 more sources