Results 41 to 50 of about 4,993,363 (331)
Performance of the Roche Total Mycophenolic Acid® assay on the Cobas Integra 400®, Cobas 6000® and comparison to LC-MS/MS in liver transplant patients [PDF]
, 2011 Background: Mycophenolic acid (MPA) is an immunosuppressant for which therapeutic drug monitoring (TDM) is performed for optimal prophylaxis and avoidance of toxicity in transplant patients.
Decavele, An-Sofie +3 more
core +1 more source
Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]
, 2019 Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet +4 more
core +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Background: Titanium is commonly used in blood-exposed medical devices because it has superior blood compatibility. Mycophenolic acid inhibits the proliferation of vascular smooth muscle cells.
Jae Won Shim +26 more
doaj +1 more source
Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production [PDF]
, 2010 Mycophenolic acid is a commonly used immunosuppressant after organ transplantation and in autoimmune diseases; however, myelosuppression is a major complication despite its largely favorable side-effect profile.
Ley, Klaus +2 more
core +1 more source
Monitoring mycophenolic acid [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2002 The immunosuppressive agent mycophenolate mofetil is a prodrug for the active compound mycophenolic acid. Following organ transplantation, it is used mostly in combination with other immunosuppressive drugs, but it has also been used as primary therapy.
openaire +3 more sources
Population pharmacokinetics of mycophenolic acid in paediatric patients
British Journal of Clinical Pharmacology, 2020 Mycophenolic acid (MPA) is widely used in paediatric kidney transplant patients and sometimes prescribed for additional indications. Population pharmacokinetic or pharmacodynamic modelling has been frequently used to characterize the fixed, random and ...
Yan Rong, Heajin Jun, Tony K. L. Kiang
semanticscholar +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2020 A reliable method has been validated using ultra-performance liquid chromatography mass spectrometry (MS)/MS for simultaneous evaluation of human plasma concentration of mycophenolic acid (MPA) and its major metabolites both total and free form.
Napatsanan Tanathitiphuwarat +6 more
doaj +1 more source
Effect of protein binding on exposure of unbound and total mycophenolic acid: a population pharmacokinetic analysis in Chinese adult kidney transplant recipients [PDF]
Front. Pharmacol. (2020) 11:340, 2019 AIMS A population pharmacokinetic (PK) analysis was performed to: (1) characterise the PK of unbound and total mycophenolic acid (MPA) and its 7-O-mycophenolic acid glucuronide (MPAG) metabolite, and (2) identify the clinically significant covariates that cause variability in the dose-exposure relationship to facilitate dose optimisation.
arxiv +1 more source
JAMA dermatology, 2020 Importance First-line systemic therapy for morphea includes methotrexate with or without systemic corticosteroids. When this regimen is ineffective, not tolerated, or contraindicated, a trial of mycophenolate mofetil (MMF) or mycophenolic acid (MPA ...
M. Arthur +22 more
semanticscholar +1 more source
Bacterial IMPDH Gene Used for the Selection of Mammalian Cell Transfectants
BioTechniques, 2003 Stable cell transfection is used for the expression of exogenous genes or cDNAs in eukaryotic cells. Selection of these transfectants requires a dominant selectable marker. A variety of such markers has been identified and is currently in use.
Mekhine Baccam, Eliezer Huberman
doaj +1 more source