Results 41 to 50 of about 21,722 (233)

Kidney Transplantation for Erdheim-Chester Disease

open access: yesCase Reports in Transplantation, 2020
Erdheim-Chester disease is a rare inflammatory disease that infiltrates skeletal and extra-skeletal tissue. Chronic kidney disease (CKD) in Erdheim-Chester disease is usually attributed to retroperitoneal lesions that lead to urologic obstruction and ...
Jongwon Yoo   +8 more
doaj   +1 more source

Mycotoxicological monitoring. Part 1. Complete mixed feed for pigs and poultry (2009–2018)

open access: yesВетеринария сегодня, 2020
Results of the ten-year annual mycotoxicological testing of complete mixed feeds for pigs and poultry submitted by holdings and processing establishments located in the Northwestern, Central, Southern, Volga and Ural Federal Districts are presented ...
G. P. Kononenko   +2 more
doaj   +1 more source

A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

open access: yesCommunications Biology, 2021
Guste Urbonaite and Jimmy Tsz Hang Lee et al. present a droplet-based single-cell sequencing method optimized for use in yeast. They use their method—yeastDropSeq—to investigate the changes in gene expression profiles following treatment with the ...
Guste Urbonaite   +5 more
doaj   +1 more source

In vitro activity of immunosuppressive drugs against Plasmodium falciparum [PDF]

open access: yes, 2014
Background Solid organ transplant recipients are particularly vulnerable for infectious diseases due to prolonged immunosuppressive treatment. Residents of endemic regions and travellers may be exposed to malaria and may, therefore, require prolonged ...
Felix Loetsch   +6 more
core   +2 more sources

Stability of Mycophenolic Acid and Mycophenolic Acid Glucuronide in Human Plasma [PDF]

open access: yesClinical Chemistry, 1999
Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is being used increasingly in immunosuppressant therapy after solid organ transplantation (1)(2)(3). Its immunosuppressive activity is thought to reside in the inhibition of inosine monophosphate dehydrogenase (IMPDH), leading to a suppression of purine nucleotide synthesis ...
M, Shipkova   +6 more
openaire   +2 more sources

Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3. [PDF]

open access: yes, 1991
The T cell antigen receptor consists of the Ti alpha/beta heterodimer which recognizes antigen, and the associated CD3 chains, thought to be involved in signal transduction.
Tan, L, Turner, J, Weiss, A
core   +1 more source

Immunosuppressant mycophenolic acid biosynthesis employs a new globin-like enzyme for prenyl side chain cleavage

open access: yesActa Pharmaceutica Sinica B, 2019
Mycophenolic acid (MPA, 1) and its derivatives are first-line immunosuppressants used in organ transplantation and for treating autoimmune diseases. Despite chemical synthetic achievements, the biosynthetic formation of a seven-carbon carboxylic acid ...
Xiwei Chen   +6 more
doaj   +1 more source

Titer improvement of mycophenolic acid in the novel producer strain Penicillium arizonense and expression analysis of its biosynthetic genes

open access: yesBMC Microbiology, 2023
Mycophenolic acid (MPA) is the active ingredient in the most important immunosuppressive pharmaceuticals. It has antifungal, antibacterial, antiviral, anti-psoriasis, and antitumor activities.
Hala A. Ammar   +3 more
doaj   +1 more source

Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report

open access: yesClinical Case Reports, 2022
Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea.
Ryota Tanaka   +6 more
doaj   +1 more source

First-principles molecular structure search with a genetic algorithm

open access: yes, 2015
The identification of low-energy conformers for a given molecule is a fundamental problem in computational chemistry and cheminformatics. We assess here a conformer search that employs a genetic algorithm for sampling the low-energy segment of the ...
Baldauf, Carsten   +2 more
core   +2 more sources

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