Advanced Science, EarlyView.Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao +13 more
wiley +1 more source
Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents
Microbiology Spectrum, 2023 Mpox virus (formerly monkeypox virus [MPXV]) is a neglected zoonotic pathogen that caused a worldwide outbreak in May 2022. Given the lack of an established therapy, the development of an anti-MPXV strategy is of vital importance.
Takayuki Hishiki +20 more
doaj +1 more source
Successful treatment of HIV‐associated lupus‐like glomerulonephritis with mycophenolic acid
Clinical Case Reports, 2020 HIV‐associated lupus‐like glomerulonephritis is an uncommon but well‐described entity. Treatment has traditionally focused on control of HIV viremia with some using adjuvant steroids.
Mark Tiong +3 more
doaj +1 more source
Biotransformations of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures [PDF]
, 2007 Guillermo Schmeda-Hirschmann and Carlos Aranda Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. Jaime A. Rodríguez and Cristina Theoduloz. Depto.
Aranda, C. +4 more
core +2 more sources
Lack of an Effect of Oral Iron Administration on Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients [PDF]
, 2007 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90055/1/phco.27.9.1272 ...
Bullingham R +6 more
core +1 more source
Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease
Arthritis &Rheumatology, EarlyView.Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman +2 more
wiley +1 more source
Methodical approaches to bioassay of substances containing unstable functional groups [PDF]
Research Results in Pharmacology, 2018 Introduction: This article describes the method development approaches for bioassay of substances containing unstable functional groups and forming unstable metabolites using the example of mycophenolic acid, methyldopa and mebeverine metabolites.
Alexander L. Khokhlov +4 more
doaj +3 more sources
Arthritis &Rheumatology, EarlyView.Objective The optimal treatment strategy for rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) remains uncertain, and direct comparative data between biologics are limited. This study aimed to evaluate the effectiveness and safety of abatacept compared with rituximab in patients with RA‐ILD.
Po‐Cheng Shih +3 more
wiley +1 more source
Immunosuppressant prescription pattern and trend in kidney transplantation: A multicenter study in Korea. [PDF]
PLoS ONE, 2017 The actual prescription pattern of immunosuppressive agents in kidney transplantation is unclear.We investigated the pattern and trend of immunosuppressive treatment for kidney transplant patients in South Korea.
Ji-Yeun Chang +11 more
doaj +1 more source
Large scale analysis of routine dose adjustments of mycophenolate mofetil based on global exposure in renal transplant patients. [PDF]
, 2011 International audienceBACKGROUND: : We report a feasibility study based on our large-scale experience with mycophenolate mofetil dose adjustment based on mycophenolic acid interdose area under the curve (AUC) in renal transplant patients.
Debord, Jean +5 more
core +2 more sources