Results 61 to 70 of about 4,993,363 (331)
Mycophenolic acid pharmacogenomics in kidney transplantation
, 2020 Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute rejection in kidney transplantation. MPA reversibly inhibits the enzymes involved in the synthesis of guanosine nucleotides, thus preventing DNA replication of immune ...
F. D. Genvigir +4 more
semanticscholar +1 more source
IMP-dehydrogenase inhibition in human lymphocytes and lymphoblasts by mycophenolic acid and mycophenolic acid glucuronide [PDF]
Clinical Chemistry, 1997 AbstractInosine 5′-monophosphate dehydrogenase (IMP-DH) activities were measured in human lymphocytes (exhibiting type I IMP-DH activity) and human lymphoblasts (exhibiting type II IMP-DH activity) in the presence of various amounts of mycophenolic acid (MPA) (0–20 μmol/L) and MPA glucuronide (MPAG) (0–200 μmol/L).
Andrea Griesmacher +3 more
openaire +3 more sources
Kidney Transplantation for Erdheim-Chester Disease
Case Reports in Transplantation, 2020 Erdheim-Chester disease is a rare inflammatory disease that infiltrates skeletal and extra-skeletal tissue. Chronic kidney disease (CKD) in Erdheim-Chester disease is usually attributed to retroperitoneal lesions that lead to urologic obstruction and ...
Jongwon Yoo +8 more
doaj +1 more source
Symmetry Scheme for Amino Acid Codons [PDF]
Phys.Rev.E65, 021912 (2002), 2003 Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered ...
arxiv +1 more source
ANTITUMOR ACTIVITY OF MYCOPHENOLIC ACID
The Journal of Antibiotics, 1969 Mycophenolic acid shows significant antitumor activity against several strains of transplantable mouse tumors, some of which were originally established as syngeneic in tumor-host realtionship. Mycophenolic acid was more effective against solid than ascitic tumors. Oral, subcutaneous or intraperitoneal administration was equally effective.
Kunio Ando +4 more
openaire +4 more sources
The inhibition of nucleic acid synthesis by mycophenolic acid [PDF]
Biochemical Journal, 1969 1. Mycophenolic acid, an antibiotic of some antiquity that more recently has been found to have marked activity against a range of tumours in mice and rats, strongly inhibits DNA synthesis in the L strain of fibroblasts in vitro. 2. The extent of the inhibition of DNA synthesis is markedly increased by preincubation of the cells with mycophenolic acid ...
Jennifer M. Cook, T. J. Franklin
openaire +3 more sources
Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry [PDF]
, 2010 Background: Posaconazole is a novel antifungal drug for oral application intended especially for therapy of invasive mycoses. Due to variable gastrointestinal absorption, adverse side effects, and suspected drug-drug interactions, therapeutic drug ...
Burghardt, Stephan +4 more
core +1 more source
Mycotoxicological monitoring. Part 1. Complete mixed feed for pigs and poultry (2009–2018)
Ветеринария сегодня, 2020 Results of the ten-year annual mycotoxicological testing of complete mixed feeds for pigs and poultry submitted by holdings and processing establishments located in the Northwestern, Central, Southern, Volga and Ural Federal Districts are presented ...
G. P. Kononenko +2 more
doaj +1 more source
Byssochlamys nivea as a Source of Mycophenolic Acid [PDF]
Applied and Environmental Microbiology, 2005 ABSTRACT Byssochlamys species are responsible for spoilage and degradation of fruits and silages and can also produce the mycotoxin patulin. We analyzed secondary metabolite production by Byssochlamys nivea .
Puel, Olivier +4 more
openaire +5 more sources
Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]
, 2012 The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
core +2 more sources