Results 231 to 240 of about 89,623 (336)

Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk   +5 more
wiley   +1 more source

In Vitro Expansion and Transduction of Primary NK Cells Using Feeder Cells Expressing Costimulatory Molecules and IL‐21

open access: yesCancer Science, EarlyView.
Our findings show that feeder cells expressing CD80, 41BBL and membrane‐bound IL‐21 promote optimal NK cell expansion. We also evaluated CAR transduction efficiency into expanded NK cells using different lentiviral vectors. The results indicate that NK cells transduced with the BaeV lentivirus exhibit high cytotoxicity toward target cells.
Thi Bao Tram Tran   +12 more
wiley   +1 more source

Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression

open access: yesCancer Science, EarlyView.
In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu   +6 more
wiley   +1 more source

Review of respiratory syndromes in poultry: pathogens, prevention, and control measures. [PDF]

open access: yesVet Res
Liu H   +8 more
europepmc   +1 more source

Cancer‐Type‐Specific DNA Methylation Is a Source of Vulnerability in Liver Cancer Cells

open access: yesCancer Science, EarlyView.
We profiled genome‐wide DNA methylation in 1165 human cancer cell lines representing 25 cancer types and identified 73 genes as potential liver cancer‐specific methylation‐silenced genes. We selected ASNS, BCAT2, FXYD5, and NQO1 genes for further experimental analysis and demonstrated that aberrant methylation of BCAT2 contributes to the vulnerability ...
Karen Minowa   +3 more
wiley   +1 more source

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