Results 61 to 70 of about 72,574 (263)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Role of Lipoproteins in Mycoplasma-Mediated Immunomodulation

Frontiers in Microbiology, 2018
Mycoplasma infections, such as walking pneumonia or pelvic inflammatory diseases, are a major threat to public health. Despite their relatively small physical and genomic size, mycoplasmas are known to elicit strong host immune responses, generally ...
Alexei Christodoulides, Neha Gupta, Vahe Yacoubian, Neil Maithel, Jordan Parker, Theodoros Kelesidis   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Emerging resistance in genital mycoplasmas: 6-year trends of Ureaplasma spp. and Mycoplasma hominis infections in Eastern China

BMC Infectious Diseases
Background To investigate the epidemiological profile and antimicrobial resistance patterns of genital mycoplasma in Eastern China and provide evidence-based guidance for clinical management.
Yu-qiong Zhang, Ning Su, Lan Huang, Wei-dong Xu, Ya-nan Wang, Jing-jing Gao   +5 more
doaj   +1 more source

Rapid Detection and Antibiotic Susceptibility of Genital Mycoplasma Isolated from Male with Urethritis and Prostatitis, Iraq

Journal of Pure and Applied Microbiology, 2017
Ureaplasma urealyticum and Mycoplasma hominis are most important genital mycoplasma responsible for many genitourinary tract infections. Nongonococcal urethritis (NGU) and bacterial prostatitis are most clinically significant infections that affect a ...
Hussein O.M. Al-Dahmoshi, Hasananin K. Al-Sharef, Samah A. Kadhum, Jawad A. Al-Asskar, Noor S. Al-Khafaji, Alyaa S. Karkosh   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A Disease Outbreak in Beef Cattle Associated with Anaplasma and Mycoplasma Infections. [PDF]

Animals (Basel), 2023
Persson Waller K, Dahlgren K, Grandi G, Holding ML, Näslund K, Omazic A, Sprong H, Ullman K, Leijon M.   +8 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Feline Vector-Borne Diseases and Their Possible Association with Hematological Abnormalities in Cats from Midwestern Brazil

Microorganisms
Among the parasitic and infectious diseases affecting cats, those caused by vector-borne pathogens deserve attention due to their ability to cause nonspecific clinical signs and clinicopathological abnormalities. We studied the presence of Cytauxzoon spp.
Stephani Félix Carvalho, Gracielle Teles Pádua, Warley Vieira de Freitas Paula, Mariana Avelar Tavares, Lucianne Cardoso Neves, Brenda Gomes Pereira, Rayane Almeida Santos, Gabriel Cândido dos Santos, Ennya Rafaella Neves Cardoso, Andriele Ferreira Qualhato, Raphaela Bueno Mendes Bittencourt, Nicolas Jalowitzki de Lima, Danieli Brolo Martins, Filipe Dantas-Torres, Felipe da Silva Krawczak   +14 more
doaj   +1 more source