Results 71 to 80 of about 77,206 (310)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The role of mixed Mycoplasma and Herpesvirus infections in case of skin lesions in children

Детские инфекции (Москва), 2019
Numerous literature data show the role of mycoplasma infection in the development of non-respiratory lesions of various organs and systems, including the skin.
H. O. Kuvardina, F. S. Kharlamova, I. V. Polesko, O. V. Shamsheva, O. S. Ostapuschenko   +4 more
doaj   +1 more source

Genital Mycoplasmas in Placental Infections [PDF]

Infectious Diseases in Obstetrics and Gynecology, 1994
Objective: The involvement of the genital mycoplasmas Ureaplasma urealyticum and Mycoplasma hominis in complications of pregnancy has remained controversial especially because these microorganisms are frequent colonizers of the lower genital tract.
Stein, Andreas, Boubli, Léon, Blanc, Bernard, Raoult, Didier   +3 more
openaire   +2 more sources

Mycoplasma infections in dairy cattle farms in Turkey [PDF]

, 2016
Aras, Zeki (Aksaray, Yazar)Mycoplasmas cause the most severe and economically costly diseases of cattle throughout the world. In this study, Mycoplasma species were isolated from calves and cows with suspected mycoplasmosis in Holstein dairy cattle ...
Uslu, Ali, Aras, Zeki, Uçan, Uçkun Sait, Özdemir, Özgür, Hadimli, Hasan Hüseyin, Sakmanoğlu, Aslı, Sayın, Zafer, Erganiş, Osman   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Chronic osteomyelitis with pathological fracture induced by Mycoplasma hominis infection: a case report and review of the literature

Frontiers in Medicine
Mycoplasma hominis, commonly residing in the genitourinary tract, can cause rare extragenital infections, especially in immunocompromised individuals. This report details a case of chronic osteomyelitis with a pathological femur fracture in a 79-year-old
Ling-Na Zhu, Wen-Bin Shen, Xiao-Yan Zou, Jiang-Cheng Zuo, Ning Xiao   +4 more
doaj   +1 more source

Mycoplasma genitalium Infection in Men [PDF]

The Journal of Infectious Diseases, 2017
Mycoplasmagenitalium is one of the major causes of nongonococcal urethritis (NGU) worldwide but an uncommon sexually transmitted infection (STI) in the general population. The risk of sexual transmission is probably lower than for Chlamydia trachomatis.
Horner, Patrick J, Martin, David H
openaire   +4 more sources

Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care

, 2005
Background: Lower respiratory tract infections (LRTI) are a common reason for consulting general practitioners (GPs). In most cases the aetiology is unknown, yet most result in an antibiotic prescription.
McHugh, TD, Gillespie, S H, Creer, D.D., Wallace, P.G., McHugh, T.D., Gillespie, S.H., Creer, D D, Johnston, S.L., Johnston, AR, Wallace, P G, Johnston, A R, Dilworth, J P, Sanderson, G, Sanderson, G., Johnston, S L, Ling, C., Johnston, A.R., McHugh, T D, Creer, DD, Dilworth, JP, Patel, S, Dilworth, J.P., Gillespie, SH, Ling, C, Patel, S., Wallace, PG, Johnston, SL   +26 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source