Results 181 to 190 of about 51,615 (305)

Glucose‐6‐phosphate dehydrogenase deficiency is associated with improved survival in patients with acute myeloid leukemia treated with venetoclax and azacitidine

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency impairs cellular redox balance through reduced NADPH production and is the most common enzymatic disorder‐causing anemia. Venetoclax combined with azacitidine (Ven‐Aza) targets leukemic stem cells by disrupting oxidative phosphorylation and inducing mitochondrial stress. This study
Shira Buchrits, Alon Rozental, Noa Korngold, Ofer Algor, Shirly Partouche, Galit Granot, Pia Raanani, Ofir Wolach   +7 more
wiley   +1 more source

Advances and challenges in the treatment of myelodysplastic syndromes. [PDF]

Exp Hematol Oncol
Thalla R, Mack R, Kosti-Schwartz J, Breslin P, Zhang J.   +4 more
europepmc   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Germline and somatic genetic landscape of pediatric myelodysplastic syndromes. [PDF]

Haematologica
Kotmayer L, Kennedy AL, Wlodarski MW.
europepmc   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Hotspot gene mutations and treatment response in myelodysplastic syndromes (MDS): predictive biomarkers and targeted strategies. [PDF]

Front Med (Lausanne)
Zhang R, Kou W, Wu T, Zhou R.
europepmc   +1 more source

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan   +12 more
wiley   +1 more source

LDLRAD4 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in myelodysplastic syndromes. [PDF]

Front Genet
Xu M, Wu S, Zhang K, Nie L, Li Q, Zhong J, Zhang Y, He H.   +7 more
europepmc   +1 more source

Partial Laryngectomy for Thyroid Cancer: A Single Institution Case Series With Operative Techniques

Head &Neck, Volume 48, Issue 2, Page E20-E24, February 2026.
ABSTRACT Background Partial laryngectomy has been well described as a management option for T1–3 laryngeal squamous cell cancers. However, there are a few case reports of partial laryngeal surgery for locally advanced thyroid carcinoma. Methods This is a case series of five patients with thyroid carcinoma (one primary and four recurrent) with laryngeal
Ella E. Hawes, Victoria E. Banuchi, Anastasios Maniakas, Jennifer R. Wang, Paul H. Graham, Julia D. Diersing, Naifa L. Busaidy, Maria E. Cabanillas, Ramona Dadu, Sarah Hamidi, Priyanka Iyer, Steven G. Waguespack, Salmaan Ahmed, Sahar Alizada, Alexandra Belcastro, Ranim Alsharif, Mimi I. Hu, Mark E. Zafereo   +17 more
wiley   +1 more source

Novel agents and evolving strategies for anemia management in lower-risk myelodysplastic syndromes. [PDF]

Blood Res
Hong J.
europepmc   +1 more source