Results 181 to 190 of about 52,382 (294)

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Advances and Challenges in the Management of Myelodysplastic Syndromes. [PDF]

Cancers (Basel)
Stempel JM, Kewan T, Zeidan AM.
europepmc   +1 more source

Values of Individuals With Rare Genetic Neurodevelopmental Disorders and Their Family/Caregivers in Healthcare: A Scoping Review to Inform Guideline Development

Journal of Intellectual Disability Research, Volume 70, Issue 6, Page 608-652, June 2026.
ABSTRACT Background Healthcare decision‐making for individuals with rare genetic neurodevelopmental disorders (RGNDs) associated with intellectual disabilities (ID) can be complex due to the intersection of lifelong care needs, limited medical expertise and communication barriers.
Mirthe J. Klein Haneveld, Louise Cox, Petri J. C. M. Embregts, Alistair R. Niemeijer, Martina C. Cornel, Charlotte M. W. Gaasterland, Agnies M. van Eeghen   +6 more
wiley   +1 more source

Cell Lines in Myelodysplastic Syndromes/Neoplasms (MDS) Research: A Review of Existing Models and Their Applications. [PDF]

Int J Mol Sci
Maślińska-Gromadka K, Palusińska M, Łuczak JW, Skopek R, Kraj L, Schenk T, Zelent A, Szymański Ł.   +7 more
europepmc   +1 more source

Clonal hematopoiesis in patients with cancer and cancer survivors: From clonal burden to cardiovascular diseases

Cancer, Volume 132, Issue 10, 15 May 2026.
ABSTRACT Over the past decade, clonal hematopoiesis (CH) has gained substantial attention as a prevalent, age‐associated phenomenon with major implications for hematologic malignancy, cardiovascular disease, and mortality. CH arises from the clonal expansion of hematopoietic stem cells and progenitor cells harboring somatic mutations, most commonly in ...
Christian H. Nenninger, Keith Anderson, Jenaro Espitia‐Corredor, Brittany Echevarria, Vertica Agnihotri, Zhao Wang, Scott R. Goldsmith, June‐Wha Rhee   +7 more
wiley   +1 more source

Novel Genomic Biomarkers Improve Post-Hematopoietic Cell Transplantation Relapse Risk Stratification for Patients With Myelodysplastic Syndromes. [PDF]

JCO Precis Oncol
Zhang T, Auer PL, Dong J, Chen Z, Spellman SR, Saber W, Bolon YT.   +6 more
europepmc   +1 more source

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real‐world study

International Journal of Cancer, Volume 158, Issue 10, Page 2674-2683, 15 May 2026.
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang, Jing‐jing Sun, Zhi Wan, Xiao‐yu Jing, Xia Guo, Ju Gao   +5 more
wiley   +1 more source

Impact of inflammatory cytokine polymorphisms on the progression of myelodysplastic syndromes. [PDF]

Ann Hematol
Gotoh N, Munkh-Erdene T, Hayashi A, Kasamatsu T, Kitamura M, Kojima A, Okawa T, Oda T, Miyauchi E, Sasaki N, Matsumura I, Matsumoto A, Takei H, Kobayashi N, Miyazawa Y, Ogawa Y, Handa H, Saitoh T.   +17 more
europepmc   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, Volume 600, Issue 9, Page 1265-1287, May 2026.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Evaluating the patterns of use and safety of lenalidomide treatment in myelodysplastic syndromes: a European, observational multi-registry study. [PDF]

Ther Adv Drug Saf
Kim I, Makwana A, Ezenma V, Navarcikova S, Mittal M, Ho Q, Borda H, Kaehler S.   +7 more
europepmc   +1 more source