Results 231 to 240 of about 51,615 (305)

Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
1. Hypermethylation of BRD7 promoter CpG island is a critical mechanism leading to the downregulation of BRD7 expression in nasopharyngeal carcinoma (NPC). 2. LentiCRISPRv2/dCas9‐TET1CD‐sgRNAs demethylation system could promote transcriptional activation and expression of BRD7 by reducing its methylation. 3.
Jianxia Wei, Yumei Duan, Changning Xue, Lemei Zheng, Qingqing Wei, Zubing Wu, Huizhen Xin, Ting Zeng, Hongyu Deng, Songqing Fan, Wei Xiong, Zhaoyang Zeng, Mengna Li, Ming Zhou   +13 more
wiley   +1 more source

Impact of Pre-Treatment Serum Ferritin on Response and Survival in Myelodysplastic Syndromes Treated With Azacytidine: A Multivariate Analysis. [PDF]

Cancer Med
Carrasco GM, Flores RMO, Delgado RG, Morcillo BC, Rosell Mas AI, Díaz Canales D, González MR, Gomariz MC, Escamilla-Sánchez A.   +8 more
europepmc   +1 more source

Unveiling relative lymphopenia and elevated monocyte‐to‐lymphocyte count as novel independent adverse prognostic factors in chronic myelomonocytic leukemia (CMML)—Proposal of the objective prognostic index for CMML (OPIC)

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Chronic myelomonocytic leukemia (CMML) shows marked prognostic heterogeneity. Although leukocytosis is a recognized adverse prognostic factor, the contribution of its individual components remains insufficiently defined. In a cohort of 240 patients classified according to International Consensus Classification (ICC) and World Health ...
Xavier Calvo, Abora Rial‐Villavecchia, David Roman‐Bravo, Sara Garcia‐Avila, Lucia Gomez‐Perez, Marta Salido, Anna Puiggros, Blanca Espinet, Concepcion Fernandez‐Rodriguez, Barbara Tazon‐Vega, Beatriz Bellosillo, Sandra Castaño‐Díez, Marina Díaz‐Beyá, Jordi Esteve, Carmen Lome, Lluis Colomo, Lourdes Florensa, Ana Ferrer del Álamo, Juan Jose Rodriguez‐Sevilla, Leonor Arenillas   +19 more
wiley   +1 more source

Non-curative therapies and their impact on the prognosis of patients with myelodysplastic syndromes- a retrospective matched-pairs analysis. [PDF]

Ann Hematol
Rauhe KA, Kasprzak A, Schulz F, Nachtkamp K, Strupp C, Kündgen A, Dietrich S, Mayer K, Götze KS, Hofmann WK, Giagounidis A, Gattermann N, Germing U.   +12 more
europepmc   +1 more source

Hypomorphic ATP11c is a novel regulator of decreased efficacy of transfused red blood cells in humans and mice

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Chronic red blood cell (RBC) transfusion sustains patients with diverse hematologic disorders, but repeated transfusion leads to iron overload and alloimmunization. Reducing transfusion burden requires identifying donor units that circulate more effectively after storage, yet determinants of this variability remain incompletely defined.
James C. Zimring, Ariel M. Hay, Monika Dzieciatkowska, Daniel Stephenson, Zachary B. Haiman, Steven Kleinman, Philip J. Norris, Michael P. Busch, Nareg Roubinian, Elisa Fermo, Paola Bianchi, Gregory R. Keele, Grier P. Page, Angelo D'Alessandro   +13 more
wiley   +1 more source

Neutropenia (even mild) and anemia are poor prognostic factors in myelodysplastic syndromes. [PDF]

Front Med (Lausanne)
Hausman R, Gat R, Goldschmidt N, Mittelman M, Oster HS.   +4 more
europepmc   +1 more source

Tet2 deficiency promotes IgG1+ B‐cell expansion and differentiation blockade through deregulation of the Nfkbia–c‐Rel axis

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract The germinal center (GC) reaction is essential for orchestrating humoral immunity by producing plasma cells (PCs) and memory B cells (MBCs). TET2, an α‐ketoglutarate‐dependent dioxygenase, plays a critical role in B‐cell exit from the GC and in plasma cell differentiation.
Hussein Ghamlouch, Michaël Degaud, Veronique Della‐Valle, Alexandre Eeckhoutte, Marine Armand, Amina Joudat, Camille Decaudin, Pilar M. Dominguez, Wojciech Rosikiewicz, Patrycja Pawlikowska, Walaa Darwiche, Enguerran Mouly, Sheng Li, Ari M. Melnick, Said Aoufouchi, Olivier A. Bernard   +15 more
wiley   +1 more source

Correspondence on: Oral decitabine cedazuridine with and without venetoclax in higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia: a propensity score-matched study. [PDF]

Blood Cancer J
Aguirre LE, Stone RM, DeAngelo DJ, Stahl M.   +3 more
europepmc   +1 more source

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
Sara El Hoss, Maria A. Lizarralde‐Iragorri, Thiago Trovati Maciel, Olivier Hermine   +3 more
wiley   +1 more source