Results 21 to 30 of about 2,285,924 (374)

Current challenges and unmet medical needs in myelodysplastic syndromes

Leukemia, 2021
Myelodysplastic syndromes (MDS) represent a heterogeneous group of myeloid neoplasms that are characterized by ineffective hematopoiesis, variable cytopenias, and a risk of progression to acute myeloid leukemia.
U. Platzbecker, A. Kubasch, Collin Homer-Bouthiette, T. Prebet   +3 more
semanticscholar   +1 more source

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis

Haematologica, 2010
Background Myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders with a high propensity to transform into acute myeloid leukemia.
Felicitas Thol, Eva M. Weissinger, Jürgen Krauter, Katharina Wagner, Frederik Damm, Martin Wichmann, Gudrun Göhring, Christiane Schumann, Gesine Bug, Oliver Ottmann, Wolf-Karsten Hofmann, Brigitte Schlegelberger, Arnold Ganser, Michael Heuser   +13 more
doaj   +1 more source

Clonal karyotype evolution involving ring chromosome 1 with myelodysplastic syndrome subtype RAEB-t progressing into acute leukemia [PDF]

, 2006
s Karyotypic evolution is a well-known phenomenon in patients with malignant hernatological disorders during disease progression. We describe a 50-year-old male patient who had originally presented with pancytopenia in October 1992.
Bennett JM, Bettina Wunderlich, Brigitte Poleck-Dehlin, Chen Z, Christoph Schmid, Cutler CS, De Witte T, Depil S, Georg Ledderose, Gisselsson D, Gullingsrud EO, Hans Jochen Kolb, Hebart H, Helga Schmetzer, Hoffmann WK, Hoffmeister PA, Holler E, Johann Mittermüller, Johansson B, Jotterand M, Kern W, Kolb HJ, Kolb HJ, Massenkeil G, Mattano, Mhawesch P, Mittermuller J, Moss PA, Mufti GJ, Rothe G, Sanders JE, Schmetzer H, Schmetzer H, Schmetzer HM, Schmid C, Seabright M, Seber A, Slovak ML, Sole F, Sole F, Thomas Duell, Tichelli A, Tichelli A, van Esser JW, Xu J, Yan J, Yoshida A   +46 more
core   +1 more source

The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes

Haematologica, 2019
Although cytarabine has been widely considered as one of the chemotherapy drugs for high-risk myelodysplastic syndromes (MDS), the overall response rate is only approximately 20-30%.
Peipei Lin, Yanling Ren, Xiaomei Yan, Yingwan Luo, Hua Zhang, Meenu Kesarwani, Jiachen Bu, Di Zhan, Yile Zhou, Yuting Tang, Shuanghong Zhu, Weilai Xu, Xinping Zhou, Chen Mei, Liya Ma, Li Ye, Chao Hu, Mohammad Azam, Wei Ding, Jie Jin, Gang Huang, Hongyan Tong   +21 more
doaj   +1 more source

Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia. [PDF]

, 2017
Acquired elliptocytosis is a known but rarely described abnormality in the myelodysplastic syndromes (MDS). Here we report the case of an elderly male who was admitted to the hospital with chest pain, dyspnea, and fatigue and was found to be anemic with ...
Dwyre, Denis M, Jonas, Brian A, Kjelland, Jacob D   +2 more
core   +2 more sources

Activation of cytotoxic T-cell receptor γδ T lymphocytes in response to specific stimulation in myelodysplastic syndromes

Haematologica, 2008
Background We previously reported that the function and proliferation of natural killer cells in myelodysplastic syndromes are defective. T-cell receptor γδ T cells are other important components of innate immunity that have been recently implicated in ...
Jean-Jacques Kiladjian, Géraldine Visentin, Emilie Viey, Sylvie Chevret, Virginie Eclache, Jerome Stirnemann, Jean Henri Bourhis, Salem Chouaib, Pierre Fenaux, Anne Caignard   +9 more
doaj   +1 more source

Twenty-five years of epidemiological recording on myeloid malignancies: data from the specialized registry of hematologic malignancies of Côte d’Or (Burgundy, France)

Haematologica, 2011
Background Epidemiological data on myeloid malignancies are very rare in the literature due to a lack of registration by cancer registries until 2000.
Marc Maynadié, François Girodon, Ines Manivet-Janoray, Morgane Mounier, Francine Mugneret, François Bailly, Bernardine Favre, Denis Caillot, Tony Petrella, Michel Flesch, Paule-Marie Carli   +10 more
doaj   +1 more source

The myelodysplastic syndromes [PDF]

Clinical & Laboratory Haematology, 2008
Clinicomorphological features of myelodysplastic syndromes, Antonio Pagliuca and Ghulam J. Mufti FAB and MIC classification of myelodysplastic syndromes - points of controversy, John M. Bennett incidence and epidemiology of the myelodysplastic syndromes, R. A. Cartwright pathogenesis and evolution of refractory anaemia, A. Jacobs and D.
openaire   +3 more sources

Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes

Haematologica, 2009
The myelodysplastic syndromes are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more cell lineages and increased risk of evolution to acute myeloid leukemia (AML).
Arjan A. van de Loosdrecht, Canan Alhan, Marie Christine Béné, Matteo G. Della Porta, Angelika M. Dräger, Jean Feuillard, Patricia Font, Ulrich Germing, Detlef Haase, Christa H. Homburg, Robin Ireland, Joop H. Jansen, Wolfgang Kern, Luca Malcovati, Jeroen G. te Marvelde, Ghulam J. Mufti, Kiyoyuki Ogata, Alberto Orfao, Gert J. Ossenkoppele, Anna Porwit, Frank W. Preijers, Stephen J. Richards, Gerrit Jan Schuurhuis, Dolores Subirá, Peter Valent, Vincent H.J. van der Velden, Paresh Vyas, August H. Westra, Theo M. de Witte, Denise A. Wells, Michael R. Loken, Theresia M. Westers   +31 more
doaj   +1 more source

Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management

American journal of hematology/oncology, 2020
The myelodysplastic syndromes (MDS) are a very heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). Myelodysplastic syndromes occur more frequently
G. Garcia-Manero, K. Chien, G. Montalban-Bravo   +2 more
semanticscholar   +1 more source