Results 51 to 60 of about 52,382 (294)

PTK2 and PTPN11 expression in myelodysplastic syndromes

Clinics, 2013
OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein ...
Mariana Lazarini, Joao Agostinho Machado-Neto, Leticia Frohlich Archangelo, Bruna Fernandes Mendes-Silva, Carolina Louzao Bigarella, Fabiola Traina, Sara Teresinha Olalla Saad   +6 more
doaj   +1 more source

The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.
Sabina Cenciarelli, Giulia Bruna Marchetti, Maria Iascone, Maria Grazia Patricelli, Sara Giangiobbe, Gabriella Cinzia Pozzobon, Miriam Nella Savini, Fabio Giglio, Alessandro Aiuti, Paola Carrera, Francesca Ferrua, Angela Peron   +11 more
wiley   +1 more source

The role of magnetic resonance imaging in the evaluation of transfusional iron overload in myelodysplastic syndromes

Revista Brasileira de Hematologia e Hemoterapia, 2015
Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective ...
Emmanouil Petrou, Sophie Mavrogeni, Vasiliki Karali, Genovefa Kolovou, Marie-Christine Kyrtsonis, Petros P. Sfikakis, Panayiotis Panayiotidis   +6 more
doaj   +1 more source

Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance [PDF]

, 2017
Objectives To examine contemporary survival patterns in the general population of patients diagnosed with chronic myeloid leukaemia (CML), and to identify patient groups with less than optimal outcomes. Design Prospective population-based cohort. Setting
Alex Smith, Anton Kruger, Argiris Symeonidis, Aurelia Tatic, DA Arber, Dana Mikulenková, David Bowen, EM Cremers, EM Cremers, Eva Hellström-Lindberg, F Ramos, Gina Zini, GJ Mufti, J Schemenau, Jackie Droste, Jaroslav Čermák, JM Bennett, JM Bennett, JR Landis, Judith Neukirchen, Krzysztof Mądry, L Malcovati, L Swart de, Leonie Saft, Louise de Swart, Luca Malcovati, Malgorzata Paszkowska-Kowalewska, Marius MacKenzie, Mette Skov Holm, Nicole Blijlevens, P Font, P Font, P Valent, PE Shrout, Pierre Fenaux, PL Greenberg, R Bejar, RB Howe, RD Brunning, RD Brunning, Reinhard Stauder, Teresa Vallespí, Theo de Witte, TM Westers, U Germing, U Germing, U Germing, U Germing, Ulrich Germing   +48 more
core   +3 more sources

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Pro-inflammatory proteins S100A9 and tumor necrosis factor-α suppress erythropoietin elaboration in myelodysplastic syndromes

Haematologica, 2017
Accumulating evidence implicates innate immune activation in the pathobiology of myelodysplastic syndromes. A key myeloid-related inflammatory protein, S100A9, serves as a Toll-like receptor ligand regulating tumor necrosis factor-α and interleukin-1β ...
Thomas Cluzeau, Kathy L. McGraw, Brittany Irvine, Erico Masala, Lionel Ades, Ashley A. Basiorka, Jaroslaw Maciejewski, Patrick Auberger, Sheng Wei, Pierre Fenaux, Valeria Santini, Alan List   +11 more
doaj   +1 more source

SRSF2 Is Essential For Hematopoiesis and Its Mutations Dysregulate Alternative RNA Splicing In MDS [PDF]

, 2013
Myelodysplastic syndromes (MDS) are a group of neoplasms that are ineffective in generating multiple lineages of myeloid cells and have various risks to progress to acute myeloid leukemia.
Chen, Liang, Dekelver, Russell, Fu, Xiang-Dong, Heuser, Michael, Komeno, Yukiko, Lin, Leo, Monterroza, Dora D, Qiu, Jinsong, Thol, Felicitas, Xu, YiJun, Zhang, Dong-Er   +10 more
core  

Reproducibility of the World Health Organization 2008 criteria for myelodysplastic syndromes [PDF]

, 2013
The reproducibility of the World Health Organization 2008 classification for myelodysplastic syndromes is uncertain and its assessment was the major aim of this study.
Arenillas, Leonor, Florensa Brichs, Lourdes, Luño Fernández, Elisa, Ruiz, Juan C., Sanz, Guillermo, Senent, Leonor, Spanish MDS Cooperat Grp GESMD   +6 more
core   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Erythropoiesis-stimulating agents are not associated with increased risk of thrombosis in patients with myelodysplastic syndromes

Haematologica, 2012
Background There are limited reports of thrombosis among myelodysplastic syndrome patients exposed to erythropoiesis stimulating agents. It is not clear whether erythropoiesis stimulating agents are associated with an increased risk of thrombosis in ...
Sheila Weiss Smith, Masayo Sato, Steven D. Gore, Maria R. Baer, Xuehua Ke, Diane McNally, Amy Davidoff   +6 more
doaj   +1 more source