Results 61 to 70 of about 52,382 (294)

The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome [PDF]

, 2016
This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.Myelodysplastic syndromes (MDS) are clonal stem cell disorders which frequently show a hypercellular dysplastic bone marrow (BM) associated ...
Fernández, Carlos, Flores-Montero, Juan, González González, María, Gutiérrez, María Laura, Jara-Acevedo, Maria, López, Antonio, Matarraz, Sergio, Orfao, Alberto, Teodosio, Cristina   +8 more
core   +1 more source

The revolution of myelodysplastic syndromes [PDF]

Therapeutic Advances in Hematology, 2011
Myelodysplastic syndromes (MDS) are clonal disorders of the hematopoietic system with resultant cytopenias and shortened survival. Better recognition of MDS and an aging population, some of whom have been treated with chemotherapy and radiation therapy for other cancers, is largely responsible for the growing incidence of this malignancy, which is ...
Mikkael A, Sekeres, Nelli, Bejanyan
openaire   +2 more sources

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Clinical and genetic predictors of prognosis in myelodysplastic syndromes

Haematologica, 2014
Myelodysplastic syndromes are a collection of clonal hematopoietic disorders with a wide range of clinical manifestations and eventual outcomes. Accurate prediction of a patient’s prognosis is useful to define the risk posed by the disease and which ...
Rafael Bejar
doaj   +1 more source

Effectiveness of azacitidine in unselected high-risk myelodysplastic syndromes: Results from the Spanish Registry [PDF]

, 2015
The benefit of azacitidine treatment in survival of high risk myelodysplastic syndromes (MDS) patients compared to conventional care treatment (CCT) has not been established outside clinical trials.
Amigo, M. L., Ardanaz, María Teresa, Bernal del Castillo, Teresa, Luño Fernández, Elisa, Martínez Camblor, Pablo, Nomdedeu, Benet, Paz, Raquel de, Pedro, Carme, Sánchez García, Joaquín, Xicoy, Blanca   +9 more
core   +1 more source

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, EarlyView.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Therapy-related myeloid neoplasms following treatment with radioiodine

Haematologica, 2012
Background Few data are available on therapy-related myelodysplastic syndromes and acute myeloid leukemia developing after radioiodine treatment.Design and Methods We retrospectively analyzed 39 patients with myeloid neoplasms following radioiodine ...
Thomas Schroeder, Andrea Kuendgen, Sabine Kayser, Nicolaus Kröger, Friederike Braulke, Uwe Platzbecker, Viola Klärner, Fabian Zohren, Detlef Haase, Michael Stadler, Richard Schlenk, Akos G. Czibere, Ingmar Bruns, Roland Fenk, Norbert Gattermann, Rainer Haas, Guido Kobbe, Ulrich Germing   +17 more
doaj   +1 more source

Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes:Analysis from the International Working Group for Prognosis of MDS [PDF]

, 2018
Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity.
Andrea Kuendgen, Arber, Arjan A. van de Loosdrecht, Bennett, Bhopal, Chen, Christa Fonatsch, Churpek, David Bowen, Detlef Haase, Di Bernardo, Francesc Solé, Francois Dreyfus, Greenberg, Greenberg, Guillermo Garcia-Manero, Guillermo Sanz, Haferlach, Hagop Kantarjian, Harrell, Heinz Tuechler, Intragumtornchai, Jaroslav Cermak, Jaroslaw Maciejewski, John M. Bennett, Julie Schanz, Kawabata, Kennedy, Lee, Luca Malcovati, Marilyn L. Slovak, Mario Cazzola, Matsuda, Michael Lübbert, Michael Pfeilstöcker, Michelle M. Le Beau, Mikkael A. Sekeres, Neukirchen, Papaemmanuil, Peter L. Greenberg, Peter Valent, Pierre Fenaux, Polprasert, Reinhard Stauder, RollisonDE, Savic, Schanz, Shaffer, Sigrid Machherndl-Spandl, Silvia M.M. Magalhaes, Sudhir Tauro, Suh, Team, Teras, Teresa Vallespi, Ulrich Germing, Valeria Santini, van Spronsen, Vardiman, Voso, Weiss, Wolfgang R. Sperr, World health statistics, Yasushi Miyazaki, Yoshida   +64 more
core   +5 more sources

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, EarlyView.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country [PDF]

, 2013
Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases.
Chauffaille, Maria de Lourdes, Gaiolla, R. D., Lopes, L. F., Pelicario, L. M., Tanizawa, Roberta Sandra da Silva, Toledo, Silvia Regina Caminada de, Velloso, Elvira Deolinda Rodrigues Pereira   +6 more
core   +1 more source