Results 81 to 90 of about 51,886 (205)

Recombinant human erythropoietin plus all-trans retinoic acid and testosterone undecanoate for the treatment of anemia in patients with lower-risk myelodysplastic syndromes: a multicenter, single-arm, prospective trial

Haematologica
Erythropoiesis-stimulating agents (ESAs) achieve hematological improvement-erythroid (HIE) in only 30% of ESA-naïve lower risk myelodysplastic syndrome (LR-MDS) patients with anemia, highlighting the need for developing novel drugs or new treatment ...
Chen Mei, Gaixiang Xu, Cuiping Zheng, Yaping Xie, Minming Li, Yanping Shao, Rongxin Yao, Shi Tao, Wei Jiang, Jun Guo, Zhiyin Zheng, Wei Wang, Xinping Zhou, Liya Ma, Li Ye, Yingwan Luo, Chunmei Yang, Wenjuan Yu, Wanzhuo Xie, Jie Jin, Hongyan Tong   +20 more
doaj   +1 more source

The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

Haematologica, 2012
Background Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation.
Jeffrey J. Pu, Rong Hu, Galina L. Mukhina, Hetty E. Carraway, Michael A. McDevitt, Robert A. Brodsky   +5 more
doaj   +1 more source

TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes [PDF]

, 2015
:P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase.
Basiorka, Ashley A., Cluzeau, Thomas, Epling-Burnette, P. K., Irvine, Brittany A., Ling, Zhang, List, Alan F., Maciejewski, Jaroslaw, Mallo, Mar, McGraw, Kathy L., Rollison, Dana E., Sallman, David A., Sokol, Lubomir, Solé, Francesc   +12 more
core   +3 more sources

Rare occurrence of DNMT3A mutations in myelodysplastic syndromes

Haematologica, 2011
Gene mutations and epigenetic changes have been shown to play significant roles in the pathogenesis of myelodysplastic syndromes. Recently, mutations in DNMT3A were identified in 22.1% of patients with acute myeloid leukemia.
Felicitas Thol, Claudia Winschel, Andrea Lüdeking, Haiyang Yun, Inna Friesen, Frederik Damm, Katharina Wagner, Jürgen Krauter, Michael Heuser, Arnold Ganser   +9 more
doaj   +1 more source

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia - a randomised SAL pilot study [PDF]

, 2012
INTRODUCTION: Older patients with acute myeloid leukemia (AML) experience short survival despite intensive chemotherapy. Azacitidine has promising activity in patients with low proliferating AML.
Berdel, Wolfgang E., Brandts, Christian Hubertus, Bug, Gesine, Büchner, Thomas, Dührsen, Ulrich, Ehninger, Gerhard, Gerss, Joachim, Koschmieder, Anja, Koschmieder, Steffen, Krug, Utz, Müller-Tidow, Carsten, Noppeney, Richard, Röllig, Christoph, Schaich, Markus, Schwammbach, Daniela, Serve, Hubert, Steffen, Björn, Stelljes, Matthias, Thiede, Christian, Tidow, Nicola   +19 more
core   +3 more sources

Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes

Haematologica, 2012
Background Reductions in transfusion requirements/improvements in hematologic parameters have been associated with iron chelation therapy in transfusion-dependent patients, including those with myelodysplastic syndromes; data on these reductions ...
Norbert Gattermann, Carlo Finelli, Matteo Della Porta, Pierre Fenaux, Michael Stadler, Agnes Guerci-Bresler, Mathias Schmid, Kerry Taylor, Dominique Vassilieff, Dany Habr, Andrea Marcellari, Bernard Roubert, Christian Rose   +12 more
doaj   +1 more source

Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes:Analysis from the International Working Group for Prognosis of MDS [PDF]

, 2018
Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity.
Andrea Kuendgen, Arber, Arjan A. van de Loosdrecht, Bennett, Bhopal, Chen, Christa Fonatsch, Churpek, David Bowen, Detlef Haase, Di Bernardo, Francesc Solé, Francois Dreyfus, Greenberg, Greenberg, Guillermo Garcia-Manero, Guillermo Sanz, Haferlach, Hagop Kantarjian, Harrell, Heinz Tuechler, Intragumtornchai, Jaroslav Cermak, Jaroslaw Maciejewski, John M. Bennett, Julie Schanz, Kawabata, Kennedy, Lee, Luca Malcovati, Marilyn L. Slovak, Mario Cazzola, Matsuda, Michael Lübbert, Michael Pfeilstöcker, Michelle M. Le Beau, Mikkael A. Sekeres, Neukirchen, Papaemmanuil, Peter L. Greenberg, Peter Valent, Pierre Fenaux, Polprasert, Reinhard Stauder, RollisonDE, Savic, Schanz, Shaffer, Sigrid Machherndl-Spandl, Silvia M.M. Magalhaes, Sudhir Tauro, Suh, Team, Teras, Teresa Vallespi, Ulrich Germing, Valeria Santini, van Spronsen, Vardiman, Voso, Weiss, Wolfgang R. Sperr, World health statistics, Yasushi Miyazaki, Yoshida   +64 more
core   +5 more sources

Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients

Haematologica, 2016
The clinical and histopathological distinctions between inherited versus acquired bone marrow failure and myelodysplastic syndromes are challenging.
Siobán B. Keel, Angela Scott, Marilyn Sanchez-Bonilla, Phoenix A. Ho, Suleyman Gulsuner, Colin C. Pritchard, Janis L. Abkowitz, Mary-Claire King, Tom Walsh, Akiko Shimamura   +9 more
doaj   +1 more source

Immunophenotypic analysis of erythroid dysplasia in myelodysplastic syndromes. A report from the IMDSFlow working group

Haematologica, 2017
Current recommendations for diagnosing myelodysplastic syndromes endorse flow cytometry as an informative tool. Most flow cytometry protocols focus on the analysis of progenitor cells and the evaluation of the maturing myelomonocytic lineage.
Theresia M. Westers, Eline M.P. Cremers, Uta Oelschlaegel, Ulrika Johansson, Peter Bettelheim, Sergio Matarraz, Alberto Orfao, Bijan Moshaver, Lisa Eidenschink Brodersen, Michael R. Loken, Denise A. Wells, Dolores Subirá, Matthew Cullen, Jeroen G. te Marvelde, Vincent H.J. van der Velden, Frank W.M.B. Preijers, Sung-Chao Chu, Jean Feuillard, Estelle Guérin, Katherina Psarra, Anna Porwit, Leonie Saft, Robin Ireland, Timothy Milne, Marie C. Béné, Birgit I. Witte, Matteo G. Della Porta, Wolfgang Kern, Arjan A. van de Loosdrecht   +28 more
doaj   +1 more source

Pediatric Myelodysplastic Syndromes [PDF]

Journal of Hematopathology, 2015
Pediatric myelodysplastic syndromes (MDS) are a group of rare clonal hematopoietic stem cell disorders characterized by varying degree of cytopenias, ineffective and dysplastic hematopoiesis, and the risk of leukemic transformation. The clinical, laboratory, and histologic presentation of pediatric MDS shares significant overlap with other inherited ...
openaire   +1 more source