Results 91 to 100 of about 46,577 (260)

Integration of multiparameter flow cytometry score improves prognostic stratification provided by standard models in primary myelofibrosis [PDF]

, 2022
Francesco Mannelli, Sara Bencini, Giacomo Coltro, Giuseppe Gaetano Loscocco, Benedetta Peruzzi, Giada Rotunno, Chiara Maccari, Francesca Gesullo, Miriam Borella, Chiara Paoli, Roberto Caporale, Carmela Mannarelli, Francesco Annunziato, Paola Guglielmelli, Alessandro M. Vannucchi   +14 more
openalex   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Localized Tuberculosis and Myelofibrosis with Myeloid Metaplasia : An extremely unusual presentation [PDF]

, 1996
Myelofibrosis with myeloid metaplasia (MMM) is usually considered primary agnogenic, however, it may be secondary to various diseases, The association of tuberculosis with MMIM is exceedingly rare, however, the pathogenetic relationship between the two ...
Muzaffar, Suhail
core   +1 more source

Deregulated JAK/STAT signalling in lymphomagenesis, and its implications for the development of new targeted therapies [PDF]

, 2015
Gene expression profiling has implicated several intracellular signalling cascades, including the JAK/STAT pathway, in the pathogenesis of particular subtypes of lymphoma.
Gandhi, Maher K., Scott, Linda M.
core   +1 more source

Phase 2 Study to Assess the Safety and Efficacy of Bomedemstat (MK3543) in Combination with Ruxolitinib in Patients with Myelofibrosis

, 2023
Harinder Gill, Lester Au, Garret Man Kit Leung, Dorothy Tsai, Rita Yim, Lynn Chin, Vivian Li, Paul Lee, Rock Y. Y. Leung, Elaine Lee, Hugh Young Rienhoff, Yok‐Lam Kwong   +11 more
openalex   +2 more sources

Trends in US Hematology/Oncology Physician Perceptions and Referral Practices for Hematopoietic Cell Transplant: A National Survey Conducted by NMDP

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background To evaluate trends in allogeneic hematopoietic cell transplant (HCT) referral perceptions and practices, we compared surveys of Hematology‐Oncology (Hem‐Onc) physicians conducted in 2015 (N = 150), 2019 (N = 302), and 2024 (N = 183) and reported changes over time.
Aye Mon Thida, Ankita Shah, Kelley Frederick (Steffens), Samantha Watters, Mingqian Duan, Steven Devine, Susan T. Vadaparampil, Joseph Pidala   +7 more
wiley   +1 more source

Increased angiogenesis in primary myelofibrosis: latent transforming growth factor-β as a possible angiogenic factor

Revista Brasileira de Hematologia e Hemoterapia, 2014
Objective: The aim of this work was to demonstrate a possible relationship between anti-latency-associated peptide human latent transforming growth factor beta 1 (latent TGF-β1) expression in megakaryocytes and microvascular density in bone marrow ...
Cesar Cilento Ponce, Maria de Lourdes Lopes Ferrari Chauffaille, Silvia Saiuli Miki Ihara, Maria Regina Regis Silva   +3 more
doaj   +1 more source

Budd-Chiari syndrome recurring in a transplanted liver [PDF]

, 1983
A patient with Budd-Chiari syndrome who underwent orthotopic liver transplantation and developed recurrent disease is described. The immediate postoperative period was complicated by multiple thrombotic episodes, followed by a period of apparent ...
Andrew Dekker, Asbury, Bras, Calne, Dane R. Boggs, David H. Van Thiel, Howard J. Seltman, Mitchel, Parker, Putnam, Takeuchi, Thomas E. Starzl   +11 more
core   +1 more source

Ruxolitinib Suppresses Interferon‐γ‐Induced JAK/STAT Activation in Oral Keratinocytes

Clinical and Experimental Dental Research, Volume 12, Issue 1, February 2026.
ABSTRACT Objectives The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway plays a crucial role in oral inflammatory diseases such as oral lichen planus (OLP) and periodontitis. Interferon‐gamma (IFN‐γ) is a cytokine that activates the JAK/STAT pathway.
Kim N. Stolte, Anna Fedorova, Sameh Attia, Kerstin Danker, Henrik Dommisch   +4 more
wiley   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source