Results 71 to 80 of about 27,191 (241)

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated

Haematologica, 2019
In this study we interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpG, corresponding to 10,253 genes, between myelofibrosis patients and healthy controls ...
Nicolás Martínez-Calle, Marien Pascual, Raquel Ordoñez, Edurne San José Enériz, Marta Kulis, Estíbaliz Miranda, Elisabeth Guruceaga, Víctor Segura, María José Larráyoz, Beatriz Bellosillo, María José Calasanz, Carles Besses, José Rifón, José I. Martín-Subero, Xabier Agirre, Felipe Prosper   +15 more
doaj   +1 more source

Circulating CD117+/CD34+/CD45dim Myeloblasts as Biomarkers of Disease Activity in Primary Myelofibrosis-A Pilot Study. [PDF]

EJHaem
ABSTRACT Introduction Clinical benefit measures and surrogates for leukaemic transformation or overall survival are scarce in MF. Circulating myeloblast (CMB) counts have the biological plausibility to indicate disease evolution, but they are still determined by an outdated approach with microscopic examination and fixed cut‐offs.
Abdelmaksoud MT, Hevessy Z, Bedekovics J, Méhes G, Illés Á, Simon Z, Pinczés LI.   +6 more
europepmc   +2 more sources

Brucellosis presenting as myelofibrosis: First case report

, 2010
SummaryWe describe the case of a 29-year-old woman who presented with pancytopenia and myelofibrosis. Brucella melitensis was identified in her blood. The patient recovered completely with doxycycline and rifampin.
Al-Hadidy, Azmy M., Awidi, Abdallah S., Tarawneh, Musleh, Shehabi, Asem, Azmy M. Al-Hadidy, Musleh Tarawneh, Abdallah S. Awidi, Mohammed A. Abu-Fara, Al-Bsoul, Nazzal M., Nazzal M. Al-Bsoul, Ahmad Y. Magableh, Bakri, Faris G., Faris G. Bakri, Asem Shehabi, Magableh, Ahmad Y., Abu-Fara, Mohammed A.   +15 more
core   +1 more source

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice [PDF]

, 2018
Unlike primary myelofibrosis (PMF) in adults, myelofibrosis in children is rare. Congenital (inherited) forms of myelofibrosis (cMF) have been described, but the underlying genetic mechanisms remain elusive.
Ernest Turro, Calicchio, M.L., Senis, Yotis A, Fleming, M.D., Crispin, Andrew, Heemskerk, Johan W. M., Jarvis, G.E., Campagna, Dean R, Hofmann, I., Kathleen Freson, Calicchio, Monica L., Obeng, Esther A., Eble, Johannes A., Corinne Pondarré, Campagna, Dean R., Vögtle, T., Turro, Ernest, Senis, Yotis A., Obeng, E.A., Geer, Mitchell J., Yotis A. Senis, Mazharian, Alexandra, Barr, A.J., Vögtle, Timo, Gavin E. Jarvis, van Geffen, J.P., Schmitz-Abe, K., Kuijpers, Marijke J E, Silke Heising, Crispin, A., Mitchell J. Geer, Esther A. Obeng, Mazharian, A., Dean R. Campagna, Douglas, Michael, Inga Hofmann, Kuijpers, Marijke J.E., Kuijpers, Marijke J. E., van Geffen, Johanna P., Campagna, D.R., Geer, Mitchell J, Markianos, K., Ouwehand, W.H., Obeng, Esther A, Kyriacos Markianos, Pondarré, C., Markianos, Kyriacos, Senis, Y., Alastair Barr, Willem H. Ouwehand, Ouwehand, Willem H, Marijke J. E. Kuijpers, Pondarré, Corinne, Klaus Schmitz-Abe, van Geffen, Johanna P, Heising, S., Johannes A. Eble, Michael Douglas, Eble, Johannes A, Eble, J.A., Jarvis, Gavin E, Hofmann, Inga, Heemskerk, J.W.M., Mark D. Fleming, Jarvis, Gavin E., Favier, Rémi, Andrew Crispin, Fleming, Mark D., Kuijpers, M.J.E., Rémi Favier, Calicchio, Monica L, Alexandra Mazharian, Freson, K., Fleming, Mark D, Douglas, M., Heemskerk, Johan W.M., Geer, M.J., Barr, Alastair, Turro, E., Johan W. M. Heemskerk, Schmitz-Abe, Klaus, Heemskerk, Johan W M, Freson, Kathleen, Heising, Silke, Favier, R., Timo Vögtle, Ouwehand, Willem H., Johanna P. van Geffen, Monica L. Calicchio   +88 more
core   +1 more source

Recent developments in myelofibrosis

, 2012
Raoul Tibes, James M Bogenberger, Ruben A MesaDivision of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ, USAAbstract: The myeloproliferative neoplasm of myelofibrosis (MF) is clinically constituted by individuals both with primary MF, as well as ...
Tibes R, Mesa RA, Bogenberger JM
core  

Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report

Journal of Medical Case Reports, 2010
Introduction Idiopathic myelofibrosis is a chronic myeloproliferative disorder characterized by leukoerythroblastosis, massive splenomegaly, and increases in the reticular and collagen fibers in the bone marrow.
Yamashina Shunhei, Matsumoto Kenshi, Sakamoto Naoto, Otaka Michiro, Tamaki Kumiko, Watanabe Sumio   +5 more
doaj   +1 more source

P982: MYELOID-DERIVED SUPPRESSOR CELLS: CHARACTERIZATION IN PERIPHERAL BLOOD AND SPLEEN TISSUE OF PATIENTS WITH MYELOFIBROSIS

HemaSphere, 2022
R. Campanelli, A. Bonometti, M. Massa, C. Abbà, L. Villani, A. Carolei, P. Catarsi, M. Paulli, G. Barosi, E. Boveri, V. Rosti   +10 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A novel JAK1 variant in chronic eosinophilic leukaemia with response to benralizumab

British Journal of Haematology, EarlyView.
Isabel C. Vallecillo‐Viejo, Michael D. Claiborne, Charles F. Anderson, Samantha Shafer, Alan Saven, Bryce A. Seifert, Morgan Similuk, Magdalena Walkiewicz, Irina Maric, Pia R. Crespo, Lori Broderick, Andrew A. White, Amy D. Klion   +12 more
wiley   +1 more source

Positive and Negative Cardiovascular Effects of JAK Inhibitors in Inflammation

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Chronic inflammation, characteristic of many autoimmune diseases, such as rheumatoid arthritis (RA), or myeloproliferative neoplasms (MPNs), is an independent driver of accelerated cardiovascular (CV) risk, primarily through proinflammatory cytokines that induce atherosclerosis and endothelial dysfunction.
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source