Results 1 to 10 of about 70,346 (269)

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Haematologica, 2015
The prognosis of older patients with acute myelogenous leukemia is generally poor. The interleukin-3 receptor α-chain (CD123) is highly expressed on the surface of acute leukemia cells compared with normal hematopoietic stem cells.
Erwin M. Lee, Dean Yee, Samantha J. Busfield, Julie F. McManus, Nik Cummings, Gino Vairo, Andrew Wei, Hayley S. Ramshaw, Jason A. Powell, Angel F. Lopez, Ian D. Lewis, Martin N. McCall, Richard B. Lock   +12 more
doaj   +2 more sources

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

Haematologica, 2014
Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism of cytotoxicity is incompletely understood, making development of predictive biomarkers ...
Husheng Ding, Jennifer S. McDonald, Seongseok Yun, Paula A. Schneider, Kevin L. Peterson, Karen S. Flatten, David A. Loegering, Ann L. Oberg, Shaun M. Riska, Shengbing Huang, Frank A. Sinicrope, Alex A. Adjei, Judith E. Karp, X. Wei Meng, Scott H. Kaufmann   +14 more
doaj   +2 more sources

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia

Haematologica, 2013
Therapy-related myelodysplastic syndromes and acute myelogenous leukemia comprise a poor-risk subset of myelodysplastic syndromes and acute myelogenous leukemia.
Alan H. Shih, Stephen S. Chung, Emily K. Dolezal, Su-Jiang Zhang, Omar I. Abdel-Wahab, Christopher Y. Park, Stephen D. Nimer, Ross L. Levine, Virginia M. Klimek   +8 more
doaj   +2 more sources

Chronic myelogenous leukemia on target [PDF]

Cancer Medicine, 2018
Chronic myelogenous leukemia (CML) is commonly treated with tyrosine kinase inhibitors (TKIs) that inhibit the pro‐leukemic activity of the BCR‐ABL1 oncoprotein.
Veronika Némethová, Filip Rázga
doaj   +4 more sources

Chronic Myelogenous Leukemia [PDF]

Journal of the National Comprehensive Cancer Network, 2012
Chronic myelogenous leukemia (CML) is the one of the most common chronic myeloproliferative disorders. It has become the paradigmatic disease for molecular diagnosis and monitoring for several reasons: (1) CML has a unitary molecular definition, requiring the demonstration of the t(9;22)(q34;q11) chromosomal translocation or its product, the BCR-ABL ...
Susan, O'Brien, Camille N, Abboud, Mojtaba, Akhtari, Jessica, Altman, Ellin, Berman, Daniel J, DeAngelo, Steven, Devine, Amir T, Fathi, Jason, Gotlib, Madan, Jagasia, Joseph O, Moore, Javier, Pinilla-Ibarz, Jerald P, Radich, Vishnu V B, Reddy, Neil P, Shah, Paul J, Shami, B Douglas, Smith, David S, Snyder, Meir, Wetzler, Furhan, Yunus   +19 more
openaire   +5 more sources

Priapism as the first manifestation in chronic myeloid leukemia: A case report and focused review of literature

Clinical Case Reports, 2021
We report the case of a patient who was initially presented with ischemic priapism to the emergency department. He was treated with adrenaline intracavernous injections and aspiration with irrigation of the corpora cavernosa and distal shunt.
Claudia Lucia Sossa Melo, Carlos Alberto Orozco Orozco, Angela Maria Peña Castellanos, Maria Alejandra Rueda Perea, Cristian Orlando Porras Bueno, Carlos Ivan Romero Diaz, Helga Natalia Rojas Rodríguez   +6 more
doaj   +1 more source

Variables associated with pulmonary hypertension screened by echocardiography in chronic myeloid leukemia patients on dasatinib therapy

Frontiers in Cardiovascular Medicine, 2022
BackgroundPulmonary hypertension (PH) is a rare but life-threatening adverse event (AE) of dasatinib, but the associated variables are not clear. This study aimed to explore the variables associated with PH by echocardiography in patients with chronic ...
Wenying Jin, Sen Yang, Chao Yu, Tiangang Zhu, Qian Jiang, Qian Jiang   +5 more
doaj   +1 more source

Combination therapy using TGF-β1 and STI-571 can induce apoptosis in BCR-ABL oncogene-expressing cells

Biomolecular Concepts, 2021
The BCR-ABL oncogene is a tyrosine kinase gene that is over-expressed in CML. It inhibits the TGF-β1 signaling pathway. Due to resistance of cells to the tyrosine kinase inhibitor, STI-571, the combined effect of STI-571 and TGF-β1 on K562 cells was ...
Bakhshayesh Masoome, Gohari Ladan Hosseini, Barati Mahmood, Safa Majid   +3 more
doaj   +1 more source

Granulocytic Sarcoma with Compressive Myelopathy: A Rare Presentation of Chronic Myelogenous Leukemia [PDF]

Journal of Clinical and Diagnostic Research, 2014
Granulocytic sarcoma occurs most commonly in acute myelogenous leukemia. The appearance of granulocytic sarcoma in chronic myelogenous leukemia signals accelerated phase/ blast transformation.
Abhijeet P. Ganapule, Auro Viswabandya, Anita Jasper, Palak Patel, Gautami Kokil   +4 more
doaj   +1 more source

Myelogenous Leukemia in the Rat [PDF]

Blood, 1962
Abstract Observations on growth and other characteristics of subcutaneously transplanted chloroleukemia in non-inbred rats have been described in this report. This chloroleukemia cytologically is an acute or subacute, not chronic, myelogenous leukemia.
Andrew D. Dorr, Geraldine Dowd, William C. Moloney, Antonio E. Boschetti   +3 more
openaire   +3 more sources