Results 31 to 40 of about 128,118 (293)

Management of imatinib-resistant CML patients [PDF]

, 2007
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option.
Branford S, Burger H, Burgess MR, Cortes J, Crossman LC, Donato NJ, Druker BJ, Gambacorti-Passerini C, Giles F, Hochhaus A, Hughes TP, Iacobucci I, Kantarjian H, Lahaye T, Mahon FX, Melo JV, O'Hare T, Quintas-Cardama A, Rousselot P, Sleijfer S, Soverini S, Weisberg E   +21 more
core   +1 more source

Decitabine Induced Delayed Cardiomyopathy in Hematologic Malignancy

Case Reports in Cardiology, 2018
Decitabine is a pyrimidine analogue of nucleoside cytidine, used for the treatment of myelodysplastic syndromes, chronic myelogenous leukemia, and acute myelogenous leukemia.
Pradyumna Agasthi, Hemalatha Narayanasamy, Dan Sorajja, James Slack, Farouk Mookadam   +4 more
doaj   +1 more source

Pharmacoeconomic modeling of target therapy of chronic myeloid leukemia in remission

Онкогематология, 2015
The article presents example of modeling for pharmacoeconomical-founded choice of chronic myelogenous leukemia treatment strategy related to therapeutic efficacy and economical rationality. The economic model of chronic myelogenous leukemia diagnosis and
V. A. Shuvaev, K. M. Abdulkadyrov, I. S. Martynkevich, M. S. Fominykh   +3 more
doaj   +3 more sources

MTSS1 is a critical epigenetically regulated tumor suppressor in CML [PDF]

, 2015
Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr ...
Braunschweig, T., Brümmendorf, T. H., Chatain, N., Copland, M., Costa, I. G., Gusmao, E. G., Haenzelmann, S., Hamilton, A., Helgason, G.V., Herrmann, O., Holyoake, T. L., Kintsler, S., Koschmieder, S., Li, S., Merle Reher, M., Müller-Tidow, C., Schemionek, M., Schubert, C., Schwab, A.   +18 more
core   +1 more source

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

Haematologica, 2014
Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism of cytotoxicity is incompletely understood, making development of predictive biomarkers ...
Husheng Ding, Jennifer S. McDonald, Seongseok Yun, Paula A. Schneider, Kevin L. Peterson, Karen S. Flatten, David A. Loegering, Ann L. Oberg, Shaun M. Riska, Shengbing Huang, Frank A. Sinicrope, Alex A. Adjei, Judith E. Karp, X. Wei Meng, Scott H. Kaufmann   +14 more
doaj   +1 more source

Isolated hyperbilirubinemia as the manifestation of acute liver failure in a patient with acute myelogenous leukemia and COVID-19 infection

European Journal of Translational Myology, 2021
Acute liver failure is a rare but catastrophic syndrome. Liver function tests usually reveal cholestatic or hepatocellular pattern, but in this case, we report a previously undescribed manifestation of this condition as isolated hyperbilirubinemia.
Nasrin Gholami, Vahid Sheykhzadeh Amzajerdi, Rahim Mehdioghli, Hengameh Khadivi Heris, Mona Jahandideh Kazempour   +4 more
doaj   +1 more source

Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia

Cell Death Discovery, 2016
The olfactory receptor (OR) family was found to be expressed mainly in the nasal epithelium. In the last two decades members of the OR family were detected to be functional expressed in different parts of the human body such as in liver, prostate or ...
Stavros Manteniotis, Sebastian Wójcik, P. Brauhoff, Michael Möllmann, L. Petersen, Joachim R. Göthert, W. Schmiegel, Ulrich Dührsen, G. Gisselmann, Hanns Hatt   +9 more
semanticscholar   +1 more source

Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases [PDF]

, 2006
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors.
Adimy, Mostafa, Crauste, Fabien, Ruan, Shigui   +2 more
core   +5 more sources

Dasatinib: ten years of clinical practice worldwide

Онкогематология, 2016
The article contains results of meta-analysis of experience in use of second-generation tyrosine kinase inhibitors – dasatinib. The results of clinical trials dasatinib therapy in chronic myelogenous leukemia imatinib-resistant or intolerant patients are
K. M. Abdulkadyrov, V. A. Shuvaev, I. S. Martynkevich   +2 more
doaj   +1 more source

Deorphanization and characterization of the ectopically expressed olfactory receptor OR51B5 in myelogenous leukemia cells

Cell Death Discovery, 2016
The ectopic expression of olfactory receptors (ORs) in the human body has been of major interest in the past decade. Several studies have reported the expression of ORs not only in healthy tissues such as heart, sperm or skin cells, but also in cancerous
Stavros Manteniotis, Sebastian Wójcik, Joachim R. Göthert, J. Dürig, Ulrich Dührsen, G. Gisselmann, Hanns Hatt   +6 more
semanticscholar   +1 more source