Results 11 to 20 of about 47,824 (192)

Chronic myeloid leukemia presenting with isolated central nervous system lymphoid blast crisis: A case report [PDF]

Rare Tumors
Background Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the Philadelphia chromosome, typically progressing through chronic, accelerated, and blast phases. Blast crisis may be myeloid or lymphoid.
Álvaro Zarama-Valenzuela, Monica Arévalo-Zambrano, Álvaro Cadena-Andrade, Alejandro Zárate-Mesa   +3 more
doaj   +2 more sources

BET bromodomain proteins; myeloid-lymphoid or mixed-lineage leukemia 3 (MLL3) [PDF]

Science-Business eXchange, 2014
openaire   +2 more sources

Myeloid-lymphoid or mixed-lineage leukemia (MLL; HRX); heat shock protein 90 (Hsp90) [PDF]

Science-Business eXchange, 2014
openaire   +3 more sources

Kinase Inhibition in Relapsed/Refractory Leukemia and Lymphoma Settings: Recent Prospects into Clinical Investigations

Pharmaceutics, 2021
Cancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates.
Caio Bezerra Machado, Flávia Melo Cunha de Pinho Pessoa, Emerson Lucena da Silva, Laudreísa da Costa Pantoja, Rodrigo Monteiro Ribeiro, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Raquel Carvalho Montenegro, Rommel Mário Rodriguez Burbano, André Salim Khayat, Caroline Aquino Moreira-Nunes   +10 more
doaj   +1 more source

DETECTION OF BCR-ABL PROTEIN IN CHRONIC MYELOID LEUKEMIA PATIENTS USING IMMUNOCYTOCHEMISTRY

The Iraqi Journal of Medical Sciences, 2016
Background: Chronic Myeloid leukemia (CML) is a myeloproliferetive disorder associated with chromosomal abnormality, Philadelphia chromosome (Ph), in more than 95% of CML patients. The resulting BCR-ABL fused gene is markers for this type of leukemia. In
Maysaa Abdul Razaq Dhahi, Nidhal Abdul Mohaymen, Nabeel S. Murad   +2 more
doaj   +6 more sources

The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors

Haematologica, 2018
Diseases with clonal hematopoiesis such as myelodysplastic syndrome and acute myeloid leukemia have high rates of relapse. Only a small subset of acute myeloid leukemia patients are cured with chemotherapy alone. Relapse in these diseases occurs at least
Rajeswaran Mani, Swagata Goswami, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Amber Gordon, Donna Bucci, David M. Lucas, Alice Mims, Christopher Brooks, Adrienne Dorrance, Alison Walker, William Blum, John C. Byrd, Gerard Lozanski, Sumithira Vasu, Natarajan Muthusamy   +18 more
doaj   +1 more source

Hemostatic and thrombotic parameters in acure leukemia- A comparison of pre and post remission induction phase

Liaquat Medical Research Journal, 2022
This study was aimed to compare hemostatic, fibrinolytic and thrombotic parameters in pre and post induction chemotherapy in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL).
Tehmina Nafees Sonia Khan, Tariq Masood, Zara tul ain Bashir, Tasneem Farzana, Abdul Sattar, Tahir Shamsi   +5 more
doaj   +1 more source

Current Management of Chronic Myeloid Leukemia Myeloid Blast Phase

Clinical Medicine Insights: Oncology, 2022
Despite the major advancements in the management of chronic phase (CP) chronic myeloid leukemia (CML), blast crisis (BC) remains a major therapeutic challenge. BC can be myeloid, lymphoid, or mixed lineage with myeloid BC being the most common type.
Binoy Yohanan, Binsah George
doaj   +1 more source

Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies

The Journal of Clinical Investigation, 2023
The B cell leukemia/lymphoma 2 (BCL-2) inhibitor venetoclax is effective in chronic lymphocytic leukemia (CLL); however, resistance may develop over time.
Stephen Jun Fei Chong, Fen Zhu, Olga Dashevsky, Rin Mizuno, Jolin X.H. Lai, Liam Hackett, Christine E. Ryan, Mary C. Collins, J. Bryan Iorgulescu, Romain Guièze, Johany Penailillo, Ruben Carrasco, Yeonjoo C. Hwang, Denise P. Muñoz, Mehdi Bouhaddou, Yaw Chyn Lim, Catherine J. Wu, John N. Allan, Richard R. Furman, Boon Cher Goh, Shazib Pervaiz, Jean-Philippe Coppé, Constantine S. Mitsiades, Matthew S. Davids   +23 more
doaj   +1 more source

A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia

HemaSphere, 2018
. Previous retroviral and knock-in approaches to model human t(11;19)+ acute mixed-lineage leukemia in mice resulted in myeloproliferation and acute myeloid leukemia not fully recapitulating the human disease.
Vaia Stavropoulou, Marwa Almosailleakh, Hélène Royo, Jean-François Spetz, Sabine Juge, Laurent Brault, Patrick Kopp, Michelina Iacovino, Michael Kyba, Alexandar Tzankov, Michael B. Stadler, Gianni Cazzaniga, Antoine H.F.M. Peters, Juerg Schwaller   +13 more
doaj   +1 more source