Results 131 to 140 of about 903,302 (304)

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

British Journal of Cancer, 2018
Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC) differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is impaired under chronic inflammatory conditions, which are typical for tumour ...
Christopher Groth, Xiaoying Hu, Rebekka Weber, Viktor Fleming, P. Altevogt, J. Utikal, V. Umansky   +6 more
semanticscholar   +1 more source

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone, Alessandra Colamatteo, Teresa Micillo, Gianmarco Abbadessa, Silvia Garavelli, Clorinda Fusco, Claudia Russo, Francesco Perna, Federica Garziano, Claudia La Rocca, Maria Mottola, Giorgia Teresa Maniscalco, Simona Bonavita, Antonio Luca Spiezia, Alessia Castiello, Roberta Lanzillo, Vincenzo Brescia Morra, Claudio Procaccini, Paola de Candia, Giuseppe Matarese   +19 more
wiley   +1 more source

Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML [PDF]

, 2002
HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may
AGUIARI, Gianluca, CASTOLDI, GL, CUNEO, Antonio, DE ANGELI, C, DEL SENNO, Laura, GANDINI, D, LANZA, F, MANZATI, E, PANDOLFI, PP   +8 more
core   +1 more source

Prediction of acute myeloid leukaemia risk in healthy individuals

Nature, 2018
The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow ...
Sagi Abelson, G. Collord, Stanley W. K. Ng, O. Weissbrod, N. M. Cohen, E. Niemeyer, Noam Barda, P. Zuzarte, Lawrence E Heisler, Y. Sundaravadanam, R. Luben, S. Hayat, Ting Ting Wang, Zhen Zhao, I. Cirlan, Trevor J Pugh, David Soave, Karen Ng, Calli Latimer, Claire W. Hardy, K. Raine, David Jones, Diana Hoult, Abigail Britten, J. McPherson, M. Johansson, Faridah Mbabaali, Jenna Eagles, Jessica K. Miller, Daniel M. Pasternack, Lee E. Timms, P. Krzyzanowski, P. Awadalla, Rui J. Costa, E. Segal, S. Bratman, P. Beer, S. Behjati, I. Martincorena, Jean C. Y. Wang, K. Bowles, J. Quirós, A. Karakatsani, C. la Vecchia, A. Trichopoulou, E. Salamanca-Fernández, J. Huerta, A. Barricarte, R. Travis, R. Tumino, G. Masala, H. Boeing, S. Panico, R. Kaaks, A. Krämer, S. Sieri, E. Riboli, P. Vineis, M. Foll, J. Mckay, S. Polidoro, N. Sala, K. Khaw, R. Vermeulen, P. Campbell, E. Papaemmanuil, M. Minden, A. Tanay, R. Balicer, N. Wareham, M. Gerstung, J. Dick, P. Brennan, G. Vassiliou, L. Shlush   +74 more
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

In Brief: Myeloid-derived suppressor cells in cancer [PDF]

, 2017
The role of myeloid-derived suppressor cells (MDSCs) in cancer development has become clear over recent years, and MDSC targeting is an emerging opportunity for enhancing the effectiveness of current anticancer therapies.
Bronte, Coffelt, Cui, Di Mitri, Galon, Panni, Shojaei, Solito, Toh   +8 more
core   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation

Frontiers in Microbiology, 2019
Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent ...
Emma Poole, Christopher J. Z. Huang, Jessica Forbester, Miri Shnayder, Aharon Nachshon, Baraa Kweider, Anna Basaj, Daniel Smith, Sarah Elizabeth Jackson, Bin Liu, Joy Shih, Fedir N. Kiskin, K. Roche, E. Murphy, Mark R. Wills, Nicholas W. Morrell, Gordon Dougan, Gordon Dougan, Noam Stern-Ginossar, Amer A. Rana, John Sinclair   +20 more
doaj   +1 more source

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

Frontiers in Immunology, 2019
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types both during physiological immune defense and in pathological ...
Martha Gschwandtner, Rupert Derler, K. Midwood   +2 more
semanticscholar   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source