Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Nature, 2021 E. Yankova +24 more
semanticscholar +1 more source
Acute Leukaemia and So-Called Mediastinal 'Leukosarcomatosis' (Sternberg): With the Account of a Case Accompanied by Myeloid Substitution of the Hilus-Fat of the Kidneys [PDF]
, 1919 F. P. Weber
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Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Advanced Functional Materials, EarlyView.Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Medullary Aplasia in Chronic Myeloid Leukaemia during Busulphan Therapy [PDF]
, 1957 F. G. J. Hayhoe, David L. Kok
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Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME
Advanced Functional Materials, EarlyView.A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li +10 more
wiley +1 more source
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
Cell, 2021 Si Cheng +19 more
semanticscholar +1 more source
Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications
Advanced Healthcare Materials, EarlyView.This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin +6 more
wiley +1 more source
Resection eines erheblichen Theiles des Kreuzbeines durch dessen ganze Dicke hindurch und mit Eröffnung des Rückenmarkcanales, wegen eines centralen Knochensarcoms (Myeloid). Heilung [PDF]
, 1876 Richard Volkmann
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