Results 171 to 180 of about 919,731 (432)
Microbiology Spectrum, 2017 ABSTRACTAsthma is a heterogeneous chronic inflammatory disorder of the airways, and not surprisingly, many myeloid cells play a crucial role in pathogenesis. Antigen-presenting dendritic cells are the first to recognize the allergens, pollutants, and viruses that are implicated in asthma pathogenesis, and subsequently initiate the adaptive immune ...
Emma Persson +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Molecular Minimal Residual Disease in Acute Myeloid Leukemia
New England Journal of Medicine, 2018 BACKGROUND Patients with acute myeloid leukemia (AML) often reach complete remission, but relapse rates remain high. Next‐generation sequencing enables the detection of molecular minimal residual disease in virtually every patient, but its clinical value
M. Jongen‐Lavrencic +21 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger +2 more
wiley +1 more source
Radioactive phosphorus. II. In the treatment of myeloid leukemia [PDF]
, 1951 Henry D. Diamond, Lloyd F. Craver
openalex +1 more source
Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma [PDF]
, 2015 Background: Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact.
Bachert, Claus +8 more
core +2 more sources
MIF as an oncogenic driver of low‐heterogeneity melanomas
Molecular Oncology, EarlyView.Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran +4 more
wiley +1 more source
An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation
Frontiers in Microbiology, 2019 Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent ...
Emma Poole +20 more
doaj +1 more source
Towards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1 [PDF]
arXiv, 2006 In addition to their self-renewal capabilities, hematopoietic stem cells guarantee the continuous supply of fully differentiated, functional cells of various types in the peripheral blood. The process which controls differentiation into the different lineages of the hematopoietic system (erythroid, myeloid, lymphoid) is referred to as lineage ...
arxiv