Frontiers in Oncology, 2023 IntroductionAcute promyelocytic leukemia (APL) is a rare myeloid leukemia subtype affecting adult and pediatric populations. APL constitutes 15-20% of all childhood AML in Latin America, compared to 7% in the non-Latino population.
Marco Antonio Murillo-Maldonado +7 more
doaj +1 more source
Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]
, 2015 Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam +8 more
core +3 more sources
Cancer Reports, 2023 Background Although Ethiopia has more than 78% of leukemia cases and a significant burden of the disease, the survival of leukemia patients in the country is poorly recognized.
Bargude Balta +2 more
doaj +1 more source
Progression, Detection and Remission: Evolution of Chronic Myeloid Leukemia using a three-stage probabilistic model [PDF]
arXiv, 2022 We present a three-stage probabilistic model for the progression of Chronic Myeloid Leukemia (CML), as manifested by the leukemic stem cells, progenitor cells and mature leukemic cells. This progression is captured through the process of cell division and cell mutation, with probabilities of occurrence being assigned to both of them.
arxiv
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis [PDF]
, 2011 Granulocytes are pivotal regulators of tissue injury. However, the transcriptional mechanisms that regulate granulopoiesis under inflammatory conditions are poorly understood.
Akashi +31 more
core +3 more sources
Myeloid sarcoma as a manifestation of acute myeloid leukemia
Baylor University Medical Center Proceedings, 2021 We report a case of a 43-year-old man who presented with dyspnea because of large bilateral pleural effusions and imaging findings of a large periaortic mass with compression of the esophagus and l...
Lewis Woods, Jerry Fan, Hameed Ali
openaire +2 more sources
Hierarchy in Gene Expression is Predictive for Adult Acute Myeloid Leukemia [PDF]
, 2015 Cancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients. With a retrospective cohort analysis based on the gene expression profiles of 116 acute myeloid leukemia patients, we find that the ...
arxiv +1 more source
Studying the age of onset and detection of Chronic Myeloid Leukemia using a three-stage stochastic model [PDF]
arXiv, 2022 Chronic Myeloid Leukemia (CML) is a biphasic malignant clonal disorder that progresses, first with a chronic phase, where the cells have enhanced proliferation only, and then to a blast phase, where the cells have the ability of self-renewal. It is well-recognized that the Philadelphia chromosome (which contains the BCR-ABL fusion gene) is the ...
arxiv
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia.
New England Journal of Medicine, 2006 BACKGROUND The cause of chronic myeloid leukemia (CML) is a constitutively active BCR-ABL tyrosine kinase. Imatinib inhibits this kinase, and in a short-term study was superior to interferon alfa plus cytarabine for newly diagnosed CML in the chronic ...
B. Druker +31 more
semanticscholar +1 more source
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder [PDF]
, 2008 Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated ...
Baltimore, David +7 more
core +3 more sources