Results 121 to 130 of about 301,311 (355)
Understanding miR‐200c: an Important Player in Resistance to Cancer Treatment
Advanced Therapeutics, EarlyView.How can one microRNA alter cancer's response to therapy? miR‐200c plays a central role in therapeutic resistance by modulating epithelial‐mesenchymal transition, apoptosis, cancer stemness features, and drug efflux. This review outlines the context‐dependent functions of miR‐200c in various cancers and highlights its potential as both a biomarker and a
Fatma Sanli, Omer Faruk Karatas
wiley +1 more source
Journal of Internal Medicine, 2018 Outcomes for patients with acute myeloid leukaemia (AML) undergoing allogeneic stem cell transplantation (allo‐SCT) have significantly improved in recent years.
J. Canaani +15 more
semanticscholar +1 more source
Myeloid Leukaemia in Childhood [PDF]
BMJ, 1965 Skyring Ap, Mcgovern Vj, Goulston Kj
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Medicine, 2013 Chronic myeloid leukaemia (CML) is a clonal disorder in which cells of the myeloid lineage undergo inappropriate clonal expansion, caused by a BCR–ABL1 fusion gene resulting from a balanced translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), also known as the Philadelphia (Ph) chromosome.
openaire +2 more sources
Advanced Science, EarlyView.Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song +9 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian +18 more
wiley +1 more source
Haemoglobin and red cell enzyme changes in juvenile myeloid leukaemia. [PDF]
, 1968 D. J. Weatherall +2 more
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Advanced Science, EarlyView.In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu +10 more
wiley +1 more source