Results 31 to 40 of about 61,255 (306)
The genetics of chronic myeloid leukaemia and recent advancements in therapy
New Zealand Medical Student Journal, 2022 Each year, approximately 750 people (commonly >65 years) are diagnosed with leukaemia in the United Kingdom (UK). Of every 100 cases of leukaemia, 15 are diagnosed with Chronic Myeloid Leukaemia (CML), also referred to as chronic myelogenous leukaemia ...
Alexander Wellington
doaj +1 more source
Olutasidenib: A ray of hope in the treatment of acute myeloid leukaemia
Health Sciences Review, 2023 Acute myeloid leukaemia (AML) or Myelodysplastic syndrome (MDS) is one of the most common and life-threatening forms of blood cancer spreading worldwide.
Bhupender Nehra +3 more
doaj +1 more source
Oncogenesis, 2022 Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood.
Denise Ragusa +9 more
doaj +1 more source
Proceedings of the International Conference on Applied Innovations in ITA global disorder impacted by both genetic and environmental factors, chronic myeloid leukaemia (CML) is associated with increasing mortality and morbidity rates and has social and economic consequences.
Mustafa Yassin Khalf +1 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine +10 more
wiley +1 more source
An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
Leukemia Research Reports, 2015 We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight the NPM1 as a ...
Srivasavi Dukka, David T. Bowen
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Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack +12 more
wiley +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
Acta Dermato-Venereologica, 2022 Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time.
Hwa Jung Yook +8 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source