Results 31 to 40 of about 301,311 (355)
Nature Communications, 2020 Acute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic alterations that result in deregulation of transcriptional networks. One understudied source of transcriptional regulators are transposable elements (TEs), whose aberrant
Özgen Deniz +5 more
semanticscholar +1 more source
Nature Communications, 2018 Acute myeloid leukaemia (AML) affects people of all ages. Here, the authors model AML in vivo and demonstrate that the age of the cell of origin impacts leukaemia development and the genetic signature where adult cells of origin give rise exclusively to ...
Shahzya Chaudhury +10 more
doaj +1 more source
The FLT3 Y842D mutation may be highly sensitive to midostaurin: a case report
Journal of International Medical Research, 2022 A Y842D mutation within the activation loop of fms-like tyrosine kinase 3 (FLT3) has been shown to confer strong resistance to sorafenib in vitro .
Shujiao He +6 more
doaj +1 more source
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia
Nature Communications, 2023 Relapse within acute myeloid leukaemia may be driven by the presence of leukaemia stem cells. Here, the authors use single cell RNA-seq seq to characterise leukemia stem cells, and show miR-126 as a potential marker of resistance.
Matteo Maria Naldini +19 more
doaj +1 more source
Acute Myeloid Leukaemia: New Targets and Therapies
International Journal of Molecular Sciences, 2017 The most common acute hematological malignancy in adults is acute myeloid leukaemia (AML), accounting for more than 80% of cases in patients over 60 years of age [...].
Geoffrey Brown, E. Marcinkowska
semanticscholar +1 more source
Case Reports in Oncology, 2009 The development of acute myeloid leukaemia after low-dose radioiodine therapy and its presentation as a myeloid sarcoma of the uterine cervix are both rare events.
Anne Sophie Weingertner +5 more
doaj +1 more source
Nature Communications, 2021 Nucleophosmin (NPM1) gene mutation induces a specific gene expression program leading to acute myeloid leukaemia. Here, the authors show that mutant NPM1 activates a HOXB locus-associated long non-coding RNA which is essential for its associated ...
Ganqian Zhu +20 more
doaj +1 more source
Unilateral proptosis: extramedullary manifestation of acute myeloid leukaemia
Russian Open Medical Journal, 2016 Unilateral proptosis as a sole presentation of acute myeloid leukaemia is not very common. A systematic approach and a peripheral blood smear can help detect and arrest this fatal disease at an early stage.
Pallavi Gahlowt +5 more
doaj +1 more source
Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia
Hemato, 2021 Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell ...
Shaun D. Patterson +3 more
doaj +1 more source
A Ten Year Descriptive Study of Adult Leukaemia at Al-Jomhori Teaching Hospital in Sana'a, Yemen [PDF]
Yemeni Journal for Medical Sciences, 2014 Background: There is scarcity of data of the epidemiology of leukaemia in Arab countries including Yemen. Understanding patterns of leukaemia underpins epidemiology and can provide insight into disease etiology.
Jameel Al-Ghazaly +4 more
doaj +2 more sources