Results 41 to 50 of about 301,311 (355)
Case Reports in Hematology, 2015 Introduction. Myeloid sarcomas (MS) are rare tumours occurring at extramedullary sites. They are usually associated with other haematology disorders such as acute myeloid leukaemia, myelodysplastic syndrome, and chronic myeloproliferative neoplasms. They
Sunita Kohli, Mark Lee, Scott Marshall
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Oncogenesis, 2022 Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood.
Denise Ragusa +9 more
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An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML
Leukemia Research Reports, 2015 We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight the NPM1 as a ...
Srivasavi Dukka, David T. Bowen
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
Acta Dermato-Venereologica, 2022 Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time.
Hwa Jung Yook +8 more
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia
International Journal of Molecular Sciences, 2019 Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a poor overall survival. Reactive oxygen species (ROS) have been shown to be elevated in a wide range of cancers including AML. Whilst previously thought to be mere by-products
Jonathan R. Sillar +3 more
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Chronic myeloid leukaemia with lymphosarcoma [PDF]
Journal of Clinical Pathology, 1963 The clinical and pathological features of two patients with chronic myeloid leukaemia who died from lymphosarcoma are described. Both had been treated with busulphan which, at the time of development of lymphosarcoma and at death, appeared to be controlling the leukaemia satisfactorily.
J. S. Howell, A. G. W. Whitfield
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FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
The BCAT1 CXXC Motif Provides Protection against ROS in Acute Myeloid Leukaemia Cells
Antioxidants, 2022 The cytosolic branched-chain aminotransferase (BCAT1) has received attention for its role in myeloid leukaemia development, where studies indicate metabolic adaptations due to BCAT1 up-regulation.
James Hillier +7 more
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