Results 51 to 60 of about 301,311 (355)
Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and DNMT3B in Acute Myeloid Leukaemia
Biomarker Insights, 2019 Epigenetic alteration has been proposed to give rise to numerous classic hallmarks of cancer. Impaired DNA methylation plays a central role in the onset and progression of several types of malignancies, and DNA methylation is mediated by DNA ...
K. Wong, C. Lawrie, T. Green
semanticscholar +1 more source
Myelodysplasia and the Acute Myeloid Leukaemias
Hematology, 2002 The myelodysplastic syndromes are increasingly recognised clinical entities reflecting a stem cell defect that gives rise to ineffective clonal haematopoiesis. The spectrum extends from relatively indolent refractory anaemia through varying combinations of leucopoenia and thrombocytopenia to acute leukaemia.
Jacobs P., Wood L.
openaire +3 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
The genetics of chronic myeloid leukaemia and recent advancements in therapy
New Zealand Medical Student Journal, 2022 Each year, approximately 750 people (commonly >65 years) are diagnosed with leukaemia in the United Kingdom (UK). Of every 100 cases of leukaemia, 15 are diagnosed with Chronic Myeloid Leukaemia (CML), also referred to as chronic myelogenous leukaemia ...
Alexander Wellington
doaj +1 more source
Characterising experiences with acute myeloid leukaemia using an Instagram content analysis.
PLoS ONE, 2021 Instagram has more than one billion monthly users, which presents a unique research opportunity particularly in rare diseases or hard to reach populations.
Catriona Parker +3 more
doaj +1 more source
British Journal of Haematology, 2019 Acute myeloid leukaemia (AML) is the commonest indication for allogeneic stem cell transplantation (allo‐SCT) worldwide. The accumulated experience of allografting in AML over the last four decades has provided critical insights into both the ...
J. Loke +3 more
semanticscholar +1 more source
An update on chronic myeloid leukaemia [PDF]
Clinical Medicine, 2001 The therapy of CML is clearly 'work in progress' Although long-term follow-up data for patients treated with STI571 are not yet available, preliminary results are encouraging. STI571 is likely to be licensed in late 2001/early 2002 and will certainly find a place in the treatment of CML. Current therapeutic considerations are summarised in Fig 2.
Stephen G. O'Brien, Gail Stark
openaire +3 more sources
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Wnt Signalling in Acute Myeloid Leukaemia
Cells, 2019 Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which upregulate Wnt signalling through a variety of mechanisms.
A. Gruszka, D. Valli, M. Alcalay
semanticscholar +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source