Results 71 to 80 of about 301,311 (355)
Childhood acute myeloid leukaemia [PDF]
British Journal of Haematology, 2012 SummaryAlthough acute myeloid leukaemia (AML) has long been recognized for its morphological and cytogenetic heterogeneity, recent high‐resolution genomic profiling has demonstrated a complexity even greater than previously imagined. This complexity can be seen in the number and diversity of genetic alterations, epigenetic modifications, and ...
Hiroto Inaba +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
The power and potential of integrated diagnostics in acute myeloid leukaemia
British Journal of Haematology, 2019 The field of acute myeloid leukaemia (AML) diagnostics, initially based solely on morphological assessment, has integrated more and more disciplines.
T. Haferlach, Ines Schmidts
semanticscholar +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
British Journal of Haematology, 2019 Acute myeloid leukaemia (AML) is a lethal haematological malignancy characterized by an immunosuppressive milieu in the tumour microenvironment (TME) that fosters disease growth and therapeutic resistance.
Myrna R Nahas +20 more
semanticscholar +1 more source
Medicine, 2004 Abstract Chronic myeloid leukaemia (CML, previously termed ‘chronic granulocytic leukaemia' or ‘chronic myelogenous leukaemia') appears to result from acquisition in a single pluripotent haemopoietic stem cell of a molecular lesion that causes inappropriate expansion of its progeny.
openaire +2 more sources
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Adhesion Deregulation in Acute Myeloid Leukaemia
Cells, 2019 Cell adhesion is a process through which cells interact with and attach to neighboring cells or matrix using specialized surface cell adhesion molecules (AMs). Adhesion plays an important role in normal haematopoiesis and in acute myeloid leukaemia (AML).
A. Gruszka +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Acute leukaemoid reaction following cardiac surgery
Journal of Cardiothoracic Surgery, 2007 Chronic myelomonocytic leukaemia is an atypical myeloproliferative disorder with a natural history of progression to acute myeloid leukaemia, a complex and poorly understood response by the bone marrow to stress.
Webb Stephen T +5 more
doaj +1 more source