Results 81 to 90 of about 61,255 (306)

Leukaemia in children

South African Journal of Physiotherapy, 1981
The two major varieties of leukaemia in childhood are acute lymphocytic and acute myeloblastic leukaemia. Subclassification of acute lymphocytic leukaemia has defined groups with a good or poor prognosis and different treatment strategies are employed ...
C. D. Karabus
doaj   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

Extramedullary Myeloid Cell Tumour Presenting As Leukaemia Cutis

Indian Journal of Dermatology, 2002
We herewith report a case of extramedullary myeloid cell tumour presenting as leukaemia cutis for its rarity. It occurred in a 50 year old male patient who presented to us with a 40 days history of painless raised solid skin swellings over the trunk ...
Thappa Devinder Mohan, Basu Debdatta, Rao K Ramachandra, Karthikeyan Kaliaperumal   +3 more
doaj  

Chloroma of perianal region masquerading as perianal abscess

Indian Journal of Dermatology, 2013
Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia.
Rajeev Sen, Sunita Singh, Mahapatra S Qury, Sanjay Marwah, Garima Aggarwal, Shyam Singla   +5 more
doaj   +1 more source

The eukaryotic Initiating Factor 4E protein is overexpressed, but its level has no prognostic impact in acute myeloid leukaemia [PDF]

, 2011
Alexa S. Green, Sophie Grabar, M Tulliez, Sophie Park, Chadi Al‐Nawakil, Nicolas Chapuis, Nathalie Jacque, Lise Willems, Nabih Azar, Norbert Ifrah, François Dreyfus, Catherine Lacombe, Patrick Mayeux, Didier Bouscary, Jérôme Tamburini   +14 more
openalex   +1 more source

FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells [PDF]

, 2023
Ai Asai-Nishishita, Masahiro Kawahara, Goichi Tatsumi, Masaki Iwasa, Aya Fujishiro, Rie Nishimura, Hitoshi Minamiguchi, Katsuyuki Kito, Makoto Murata, Akira Andoh   +9 more
openalex   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Metformin induces ferroptosis associated with lipidomic remodeling in AML

Blood Advances
: Metabolic reprogramming is a hallmark of cancer and is essential for sustaining leukemogenesis. In acute myeloid leukemia (AML), a high dependency on oxidative phosphorylation (OXPHOS) is often linked to poor outcomes, and its inhibition has shown to ...
Dominique Sternadt, Diego A. Pereira-Martins, Prodromos Chatzikyriakou, Luise Albuquerque-Simões, Ming Yang, Douglas R. A. Silveira, Albertus T. J. Wierenga, Isabel Weinhäuser, Shanna M. Hogeling, Lieve L. Oudejans, Pilar Casares Alaez, Jean-Emmanuel Sarry, Christian Frezza, Gerwin A. Huls, Lynn Quek, Jan Jacob Schuringa   +15 more
doaj   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source