Results 81 to 90 of about 301,311 (355)
Chemotherapy of the Myeloid Leukaemias
Journal of the Royal College of Physicians of London, 1980 These advances in chemotherapy and supportive care of the myeloid leukaemias offer substantially improved prospects for the future. At present the intensive treatment of acute and chronic myeloid leukaemia requires the resources of a specialist unit and as many patients as possible should now be referred for diagnostic classification and remission ...
openaire +2 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Nature, 2021 E. Yankova +24 more
semanticscholar +1 more source
Nature Communications, 2018 Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the ...
O. Akinduro +15 more
semanticscholar +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Single cell analysis of clonal architecture in acute myeloid leukaemia
Leukemia, 2018 We used single cell Q-PCR on a micro-fluidic platform (Fluidigm) to analyse clonal, genetic architecture and phylogeny in acute myeloid leukaemia (AML) using selected mutations.
N. Potter +9 more
semanticscholar +1 more source
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
FEBS Open Bio, EarlyView.PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno +12 more
wiley +1 more source
EMBO Molecular Medicine, 2013 The t(8;21) chromosomal translocation activates aberrant expression of the AML1‐ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML).
Nina Cabezas‐Wallscheid +23 more
doaj +1 more source
Daunorubicin/Cytarabine Liposome: A Review in Acute Myeloid Leukaemia
Drugs, 2018 VYXEOS™ is a liposomal-encapsulated formulation of daunorubicin and cytarabine delivering a fixed, synergistic 1:5 molar ratio (hereafter referred to as daunorubicin/cytarabine liposome).
Hannah A. Blair
semanticscholar +1 more source