Results 191 to 200 of about 211,755 (262)

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

Determinants of survival in patients treated with CPX-351 for acute myeloid leukemia. [PDF]

Front Oncol
Chiusolo P, Fianchi L, Frioni F, Giammarco S, Metafuni E, Limongiello MA, Quattrone M, Criscuolo M, Giordano A, Sica S, Pagano L.   +10 more
europepmc   +1 more source

Transcriptomics-based multi-omics approach for optimizing risk stratification in acute myeloid leukemia. [PDF]

Blood Sci
Yang Y, Yan L, Fang J, Liu H, Tan X, Ma Y, Han X, Chen G, Chen Y, Gong D, Tu S, Wen Q, Li J, Zhang X, Zhang C.   +14 more
europepmc   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Is There a Future for CAR-T Therapy in Acute Myeloid Leukemia? [PDF]

Cancers (Basel)
Alati C, Pitea M, Molica M, Rossi M, Alvaro ME, Porto G, Bilardi E, Utano G, Policastro G, Micò MC, Marafioti V, Martino M.   +11 more
europepmc   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

Naval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

A case report of BCR-ABL(+) acute myeloid leukemia and literature review. [PDF]

Front Oncol
Li J, Zheng W, Dong X, Wang J, Liu K.
europepmc   +1 more source

Single cell transcriptional evolution of myeloid leukemia of Down syndrome. [PDF]

Nat Commun
Trinh MK, Schuschel K, Issa H, Thomas R, Parks C, Oszlanczi A, Ogbonnah T, Zhou D, Mamanova L, Prigmore E, Robertson ER, Hodder A, Wenger A, Anderson ND, Whitfield HJ, Treger TD, Gonçalves-Dias J, Straathof K, O'Connor D, Young MD, Jardine L, Adams S, Klusmann JH, Bartram J, Behjati S.   +24 more
europepmc   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, EarlyView.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source