Results 141 to 150 of about 232,812 (303)

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source

Genetic changes in the development of multiple myeloma

Multiple myeloma (MM) is a malignancy of clonal plasma cells (PC) which develops as a consequence of a multistep process of transformation from a normal PC to an asymptomatic stage known as monoclonal gammopathy of undetermined significance (MGUS) to MM ...
Chiecchio, Laura
core   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Diagnostic challenges posed by the wide morphological and immunophenotypic spectrum of plasma cell neoplasms. [PDF]

Blood Res
Chuang SS, Chang CC.
europepmc   +1 more source

The role of mitochondrial DNA in the tumor biology of glioblastoma multiforme and multiple myeloma [PDF]

Cancer cells preferentially metabolise glucose via aerobic glycolysis (the Warburg effect), which is less energy efficient in teens of ATP production compared to oxidative phosphorylation (OXPHOS).
Yeung, Ka Yu
core  

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Imaging B cell maturation antigen in multiple myeloma. [PDF]

J Clin Invest
Song Y, Song W, Cai W.
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Molecular Characterization of Mobilized Apheresis Hematopoietic Progenitor Cells Designated for Autologous Stem Cell Transplantation in Multiple Myeloma. [PDF]

EJHaem
Singh G, Kim K, Bollag RJ.
europepmc   +1 more source

Supplemental Table 5 from Dynamics of Mutant Hematopoietic Progenitor Cells Are Not Associated with Clinical Outcomes in Multiple Myeloma [Dataset]

Quality control of the 555 NGS samples included in the study.Instituto de Salud Carlos III Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Fondazione Italiana per la Ricerca sul Cancro Fondazione Regionale per la Ricerca ...
González Pérez, Marta Sonia, Lahuerta, Juan José, Larráyoz, María José, Guerrero, Camila, Moraleda, José María, Mateos, Maria Victoria, Erdozain, Irache, San Miguel, Jesús F., Martínez-López, Joaquín, Ríos Tamayo, Rafael, Bladé, Joan, Churruca, Oihane, Cabañas, Valentín, Vázquez, Iria, Maia, Catarina, Paiva, Bruno, Martín, Jesús, Gordillo, Natalia, Alignani, Diego, Palomera, Luis, Sarvide, Sarai, Mañu, Amagoia, Oriol, Albert, Cedena, Maria-Teresa, Puig, Noemi, Pérez, Cristina, González-Rodríguez, Ana-Pilar, Rosinol, Laura, Arriba, Felipe de, Calasanz, María José   +29 more
core   +1 more source