Results 131 to 140 of about 232,812 (303)

Measurements of Liver and Bone Marrow Proton Density Fat Fraction in the Setting of Ferumoxytol‐Enhanced MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Proton density fat fraction (PDFF) is typically measured using confounder‐corrected, multi‐echo, gradient‐recalled‐echo chemical‐shift‐encoded (CSE)‐MRI. Ferumoxytol, an iron‐based MRI contrast agent, increases liver and bone marrow (BM) R2*, a major confounder of PDFF.
Lukas Müller, Srijyotsna Volety, Jan‐Peter Grunz, Fatemeh Rashidi, Scott B. Reeder, Diego Hernando, Ali Pirasteh   +6 more
wiley   +1 more source

Subcorneal Pustular Dermatosis, a Systematic Review and Pooled Analysis of a Rare and Underdiagnosed Disease

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Subcorneal pustular dermatosis (SPD), or Sneddon–Wilkinson disease, is a rare, relapsing pustular skin condition of unknown cause, characterised by subcorneal pustules. Objectives To summarise the demographic, clinical, histopathological, management and disease course of SPD.
Mason H. Crossman, Jeffrey Weng, Alysha Vuong, Lawrence Lin, Zhao Feng Liu, Christopher Y. Chew   +5 more
wiley   +1 more source

Multiple Myeloma and Renal Failure [PDF]

, 2015
Renal failure (RF) occurs in approximately 20-30% of multiple myeloma (MM) patients at diagnosis and in more than 50% of patients with advanced disease. The pathogenesis of RF is related to the production of monoclonal light chains that can damage either
Valentina Polli, Manuela Imola, Anna Merli, Marina Ratta, Simona Tomassetti, Anna Maria Mianulli, Annalia Molinari, Patrizia Tosi, Serena Mangianti   +8 more
core  

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Standardized Minimal Residual Disease Detection By Next Generation Sequencing In Multiple Myeloma

, 2019
Background Next generation sequencing (NGS) has been applied to monitor minimal residual disease (MRD) in multiple myeloma (MM). Standardized DNA input and sequencing depth is essential for achieving a uniform sensitivity in NGS-based MRD study ...
Chim, JCS, Orfao, A, Bai, Y, Yao, Q
core  

JAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?

Movement Disorders Clinical Practice, EarlyView.
Abstract Background JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...
Elena Ardila Jurado, Koustubh Bavdhankar, Divyani Garg, Francesca Magrinelli, Huw R. Morris, Kailash P. Bhatia   +5 more
wiley   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Multiple Myeloma: Clinical Updates From the American Society of Hematology Annual Meeting 2016

, 2017
The novel clinical data for plasma cell neoplasms (smoldering myeloma, multiple myeloma (MM) and AL-amyloidosis) that were presented in the 2016 Annual Meeting of the American Society of Hematology are summarized here. Data from large phase 3 studies for
Terpos, E., on behalf of the International Myeloma Society   +1 more
core   +1 more source

The Prognostic Significance of Vitamin D Deficiency in Korean Patients With Multiple Myeloma

Background: Vitamin D deficiency is relatively common among patients with multiple myeloma. The prognostic significance of vitamin D deficiency in Asian patients with multiple myeloma remains unevaluated.
Miyoung Kim, Kyoungmin Lee, Sejin Kim, Dok Hyun Yoon, Shin Kim, Hyungwoo Cho   +5 more
core   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source