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The microenvironment in myeloma
Current Opinion in Oncology, 2020Purpose of review The aim of the review is to describe recent advances in our understanding of how multiple myeloma interacts with its cellular and molecular neighbours in the bone marrow microenvironment, and how this may provide targets for prognostication and prevention. Recent findings
Oliver C, Lomas +2 more
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Annals of Internal Medicine, 1973
Excerpt To the editor: The paper by Lindgarde and Zettervall in the March 1973 issue (pp. 396-399) reported a very interesting definitive study that conclusively demonstrated abnormal calcium bindi...
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Excerpt To the editor: The paper by Lindgarde and Zettervall in the March 1973 issue (pp. 396-399) reported a very interesting definitive study that conclusively demonstrated abnormal calcium bindi...
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Nature Reviews Disease PrimersMultiple myeloma (MM) is a haematological lymphoid malignancy involving tumoural plasma cells and is usually characterized by the presence of a monoclonal immunoglobulin protein. MM is the second most common haematological malignancy, with an increasing global incidence.
Evangelos Terpos +2 more
exaly +4 more sources
2020
Multiple myeloma is a hematological malignancy. It is characterized by the abnormal clonal proliferation of malignant plasma cells in the bone marrow and the secretion of a large number of monoclonal immunoglobulins or light chains, causing bone destruction, elevated blood calcium levels, anemia, and renal dysfunction.
Zhong, Zheng +4 more
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Multiple myeloma is a hematological malignancy. It is characterized by the abnormal clonal proliferation of malignant plasma cells in the bone marrow and the secretion of a large number of monoclonal immunoglobulins or light chains, causing bone destruction, elevated blood calcium levels, anemia, and renal dysfunction.
Zhong, Zheng +4 more
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Medical Clinics of North America, 1984
Multiple myeloma is a malignant neoplasm of plasma cells involving bone and bone marrow, frequently leading to extensive skeletal destruction, bone marrow failure, renal dysfunction, and problems related to the monoclonal myeloma proteins. Vigilant supportive care and effective chemotherapy can prolong survival and improve the quality of life in most ...
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Multiple myeloma is a malignant neoplasm of plasma cells involving bone and bone marrow, frequently leading to extensive skeletal destruction, bone marrow failure, renal dysfunction, and problems related to the monoclonal myeloma proteins. Vigilant supportive care and effective chemotherapy can prolong survival and improve the quality of life in most ...
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Leukemia & Lymphoma, 1995
Anaplastic myeloma (AM) represents a rare variety of multiple myeloma (MM) with poor prognosis. One case with special interest is reported, which presented with manifestations due to the extramedullary localization and arose in the absence of an initial diagnosis of MM.
K, Zervas +3 more
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Anaplastic myeloma (AM) represents a rare variety of multiple myeloma (MM) with poor prognosis. One case with special interest is reported, which presented with manifestations due to the extramedullary localization and arose in the absence of an initial diagnosis of MM.
K, Zervas +3 more
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Current Treatment Options in Oncology, 2007
The standard treatment approach to symptomatic myeloma consists of induction therapy, consolidation with high-dose chemotherapy and autologous hematopoietic stem cell transplantation in appropriate patients, maintenance therapy, and salvage therapy. Salvage therapy is of particular importance because not all patients respond to primary therapy, and ...
Seema, Singhal, Jayesh, Mehta
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The standard treatment approach to symptomatic myeloma consists of induction therapy, consolidation with high-dose chemotherapy and autologous hematopoietic stem cell transplantation in appropriate patients, maintenance therapy, and salvage therapy. Salvage therapy is of particular importance because not all patients respond to primary therapy, and ...
Seema, Singhal, Jayesh, Mehta
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Mayo Clinic Proceedings, 1994
To review biologic factors that may be useful in determining prognosis in patients with myeloma.The currently available clinical variables and staging systems were assessed for their predictive value in myeloma, and newly proposed prognostic factors were summarized.Because some patients with myeloma may potentially benefit by new, more intensive ...
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To review biologic factors that may be useful in determining prognosis in patients with myeloma.The currently available clinical variables and staging systems were assessed for their predictive value in myeloma, and newly proposed prognostic factors were summarized.Because some patients with myeloma may potentially benefit by new, more intensive ...
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Annual Review of Pathology: Mechanisms of Disease, 2011
Multiple myeloma (MM) is a neoplasm of post–germinal center, terminally differentiated B cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within the bone marrow (BM) and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and end-organ sequelae.
Kenneth C, Anderson, Ruben D, Carrasco
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Multiple myeloma (MM) is a neoplasm of post–germinal center, terminally differentiated B cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within the bone marrow (BM) and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and end-organ sequelae.
Kenneth C, Anderson, Ruben D, Carrasco
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The Journal of Bone and Joint Surgery. British volume, 1973
1. The case is reported of a woman aged sixty-five with widespread osteosclerosis as a feature of IgA myelomatosis. 2. Improvement was noted after treatment by cyclophosphamide and prednisolone. 3. Only two previously reported cases of myeloma with osteosclerosis of comparable extent have been found, but in forty-seven other cases in the literature ...
T S, Brown, C R, Paterson
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1. The case is reported of a woman aged sixty-five with widespread osteosclerosis as a feature of IgA myelomatosis. 2. Improvement was noted after treatment by cyclophosphamide and prednisolone. 3. Only two previously reported cases of myeloma with osteosclerosis of comparable extent have been found, but in forty-seven other cases in the literature ...
T S, Brown, C R, Paterson
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