Results 31 to 40 of about 382,920 (355)

Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma

Nature Communications, 2021
Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that also ...
Kylee H. Maclachlan, Even H. Rustad, Andriy Derkach, Binbin Zheng-Lin, Venkata Yellapantula, Benjamin Diamond, Malin Hultcrantz, Bachisio Ziccheddu, Eileen M. Boyle, Patrick Blaney, Niccolò Bolli, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura   +16 more
doaj   +1 more source

Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry

Leukemia Research Reports, 2018
We retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum.
Aya Nakaya, Hideo Yagi, Hitomi Kaneko, Satoru Kosugi, Toru Kida, Yoko Adachi, Hirohiko Shibayama, Takae Kohara, Yuri Kamitsuji, Shin-ichi Fuchida, Nobuhiko Uoshima, Eri Kawata, Hitoji Uchiyama, Yuji Shimura, Takayuki Takahashi, Fumiaki Urase, Kensuke Ohta, Tsuneyoshi Hamada, Kazue Miyamoto, Masayuki Kobayashi, Maki Shindo, Hirokazu Tanaka, Chihiro Shimazaki, Masayuki Hino, Junya Kuroda, Yuzuru Kanakura, Akifumi Takaoari-Kondo, Shosaku Nomura, Itaru Matsumura   +28 more
doaj   +1 more source

Anti‐BCMA CAR T‐Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

New England Journal of Medicine, 2019
BACKGROUND Preclinical studies suggest that bb2121, a chimeric antigen receptor (CAR) T‐cell therapy that targets B‐cell maturation antigen (BCMA), has potential for the treatment of multiple myeloma. METHODS In this phase 1 study involving patients with
N. Raje, J. Berdeja, Yi Lin, D. Siegel, S. Jagannath, D. Madduri, M. Liedtke, J. Rosenblatt, M. Maus, Ashley Turka, L. Lam, R. Morgan, Kevin G. Friedman, M. Massaro, Julie Wang, G. Russotti, Zhihong Yang, T. Campbell, K. Hege, F. Petrocca, Travis Quigley, N. Munshi, J. Kochenderfer   +22 more
semanticscholar   +1 more source

Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma

Experimental Hematology & Oncology, 2022
Cancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is necessary for tumor progression. This is no different for Multiple Myeloma (MM), a hematological cancer which develops in the bone marrow
Inge Oudaert, Arne Van der Vreken, Anke Maes, Elke De Bruyne, Kim De Veirman, Karin Vanderkerken, Eline Menu   +6 more
doaj   +1 more source

Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer

Journal of Experimental & Clinical Cancer Research, 2021
Despite  improvements in outcome, 15-25% of newly diagnosed multiple myeloma (MM) patients have treatment resistant high-risk (HR) disease with a poor survival.
Hussein Ghamlouch, Eileen M. Boyle, Patrick Blaney, Yubao Wang, Jinyoung Choi, Louis Williams, Michael Bauer, Daniel Auclair, Benedetto Bruno, Brian A. Walker, Faith E. Davies, Gareth J. Morgan   +11 more
doaj   +1 more source

Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

Nature Communications, 2017
In multiple myeloma, malignant cells expand within bone marrow. Here, the authors use multi-region sequencing in patient samples to analyse spatial clonal architecture and heterogeneity, providing novel insight into multiple myeloma progression and ...
L. Rasche, S. S. Chavan, O. W. Stephens, P. H. Patel, R. Tytarenko, C. Ashby, M. Bauer, C. Stein, S. Deshpande, C. Wardell, T. Buzder, G. Molnar, M. Zangari, F. van Rhee, S. Thanendrarajan, C. Schinke, J. Epstein, F. E. Davies, B. A. Walker, T. Meissner, B. Barlogie, G. J. Morgan, N. Weinhold   +22 more
doaj   +1 more source

Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins

Cell Death and Disease, 2023
Bruton’s tyrosine kinase inhibitors (BTKi) and CAR T-cell therapy have demonstrated tremendous clinical benefits in mantle cell lymphoma (MCL) patients, but intrinsic or acquired resistance inevitably develops.
Yijing Li, Heng-Huan Lee, Vivian Changying Jiang, Yuxuan Che, Joseph McIntosh, Alexa Jordan, Jovanny Vargas, Tianci Zhang, Fangfang Yan, Margaret Elizabeth Simmons, Wei Wang, Lei Nie, Yixin Yao, Preetesh Jain, Michael Wang, Yang Liu   +15 more
doaj   +1 more source

A differentiated effector T cell repertoire defines a functionally high-risk group of smoldering myeloma patients [PDF]

Blood Cancer Journal
Ross S. Firestone, Anish K. Simhal, Theresia Akhlaghi, Jung Hun Oh, Devin McAvoy, Kylee H. Maclachlan, Juan-Jose Garces, Sham Mailankody, Hani Hassoun, Urvi A. Shah, Neha Korde, Carlyn R. Tan, Sridevi Rajeeve, Hamza Hashmi, Alexander M. Lesokhin, Kinga Hosszu, Francesco Maura, Joseph O. Deasy, Saad Z. Usmani, Malin Hultcrantz   +19 more
doaj   +2 more sources

Myeloma of the Oesophagus [PDF]

Journal of Clinical Pathology, 1972
A case of myeloma of the oesophagus is presented. A search of the literature has revealed no other. The tumour was treated by local resection and postoperative treatment with cyclophosphamide was attempted. The patient died 14 months after operation from a massive myocardial infarct and at necropsy no tumour was found in any organ.
W T, Morris, J L, Pead
openaire   +2 more sources

Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma

New England Journal of Medicine, 2019
BACKGROUND Lenalidomide plus dexamethasone is a standard treatment for patients with newly diagnosed multiple myeloma who are ineligible for autologous stem-cell transplantation.
T. Facon, Shaji K. Kumar, T. Plesner, R. Orlowski, P. Moreau, N. Bahlis, S. Basu, H. Nahi, C. Hulin, H. Quach, H. Goldschmidt, M. O'Dwyer, A. Perrot, C. Venner, K. Weisel, J. Mace, N. Raje, M. Attal, M. Tiab, M. Macro, L. Frenzel, X. Leleu, T. Ahmadi, Christopher Chiu, Jianping Wang, R. Van Rampelbergh, C. Uhlar, R. Kobos, M. Qi, S. Usmani   +29 more
semanticscholar   +1 more source