Results 71 to 80 of about 232,812 (303)

Digital PCR for MRD detection of myeloma

, 2015
A pilot study was performed to investigate the use of digital PCR (dPCR) to detect minimal residual disease (MRD) in patients with multiple myeloma.
Gibson, J, Joshua, D, Nassif, N, Catalano, A, Suen, H, Weatherburn, C, Yang, S, McAuliffe, S, Brown, R, Woodland, N, Hart, D, Ho, PJ, Paul, C   +12 more
core   +1 more source

Early Access Program Results From Turkey and a Literature Review on Daratumumab Monotherapy Among Heavily Pretreated Patients With Relapsed/Refractory Myeloma

, 2020
The present study investigated the efficacy and safety profile of daratumumab monotherapy in 42 patients with relapsed refractory multiple myeloma through a Turkish early access program.
Besisik, Sevgi Kalayoglu, Leylagul Kaynar, Pelin Aytan, Gulbas, Zafer, Solmaz, Soner, Aytan, Pelin, Aydin, Yildiz, VURAL, FİLİZ, Tulin Tuglular, Hakan Ozdogu, Munci Yagci, Sevgi Kalayoglu Besisik, KAYNAR, LEYLAGÜL, Hacioglu, Sibel Kabukcu, Inci Alacacioglu, Yildirim, Rahsan, Turgut, Mehmet, Filiz Vural, Suleyman Sami Karti, Hakan Goker, Sibel Kabukcu Hacioglu, Rahsan Yildirim, Goksoy, Hasan Sami, Gurkan, Emel, Karti, Suleyman Sami, Mehmet Sonmez, Mehmet Turgut, Tekgunduz, Emre, Ilhan, Osman, Soner Solmaz, Emre Tekgunduz, Zafer Gulbas, Besisik, Sevgi, Paydas, Semra, Seckin Cagirgan, Yildiz Aydin, GÖKER, HAKAN, Beksac, Meral, Hasan Sami Goksoy, Ozdogu, Hakan, Osman Ilhan, Tuglular, Tulin, Sonmez, Mehmet, Cagirgan, Seckin, Alacacioglu, Inci, Emel Gurkan, Yagci, Munci, Gunes, Ahmet Kursad, Semra Paydas, Meral Beksac, Ahmet Kursad Gunes   +50 more
core   +1 more source

Baseline immunonutritional status drives CAR T-cell efficacy, survival, and safety in R/R lymphoma: validation of a pre-lymphodepletion PNI threshold

Annals of Hematology
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape for relapsed/refractory (R/R) lymphoma. However, heterogeneous responses and treatment-related toxicities remain significant challenges.
Na Zhang, Fan Yang, Rui Liu, Zhonghua Fu, Danyang Li, Yuelu Guo, Lixia Ma, Miaomiao Cao, Biping Deng, Shilin Gan, Chen Chen, Xiaoyan Ke, Kai Hu   +12 more
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Objective Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of patients at high risk of developing lymphoma are lacking.
Hanna Lidberg, Cecilia Fugmann, Juliana Imgenberg‐Kreuz   +2 more
wiley   +1 more source

Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database

Arthritis &Rheumatology, EarlyView.
Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy ...
Karine Tankovic, Pascal Claudepierre, Tat Thang Vo, Tran Trong Khoi Le, Siham Iggui, Laetitia Penso, Emilie Sbidian, Laura Pina Vegas   +7 more
wiley   +1 more source

Myeloma multiplex szervi szövődményeinek vizsgálata

, 2019
A myeloma multiplex malignus hematológiai megbetegedés. A betegség fő szervi szövődményeit a Myeloma Working Group 2014-ben kiadott legújabb ajánlása foglalja össze.
Bereczk, Edina
core  

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by immune dysregulation and fibrosis. We investigated whether abatacept modulates CD319/SLAMF7‐expressing cytotoxic T cells implicated in diffuse cutaneous SSc. Methods In this ancillary ASSET trial analysis, peripheral blood mononuclear cells from 67 participants were analyzed at baseline and months ...
Mikel Gurrea‐Rubio, Laura A. Cooney, Kohei Maeda, Phillip L. Campbell, Qi Wu, Camila I. Amarista, Alexander Stinson, Ray Ohara, Yang Mao‐Draayer, Michael L. Whitfield, Shiv Pillai, Poulami Dey, Johann E. Gudjonsson, Pei‐Suen Tsou, Dinesh Khanna, David A. Fox   +15 more
wiley   +1 more source

A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death

Blood Cancer Journal
Highlights CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu. Blocking CD73 activity with a potent, selective, orally bioavailable CD73 inhibitor ORIC-533 decreases ...
Arghya Ray, Ting Du, Xueping Wan, Yan Song, Sindhu C. Pillai, Md. Abu Musa, Teng Fang, Jared Moore, Brian Blank, Xiaohui Du, Xi Chen, Robert Warne, Dena Sutimantanapi, Fang Lui, Tatiana Zavorotinskaya, Christophe Colas, Lori Friedman, Melissa R. Junttila, Dharminder Chauhan, Kenneth C. Anderson   +19 more
doaj   +1 more source

Chimeric antigen receptor (CAR) -T cell therapy treatment Richter's transformation

Frontiers in Oncology
Background/purposeDespite advances in chronic lymphocytic leukemia treatment, effective therapies for cases with Richter’s transformation (RT) are urgently needed. This study aimed to investigate the use of chimeric antigen receptor (CAR)-T cell infusion
Shaomei Feng, Peihao Zheng, Haidi Liu, Meiling Sun, Yuelu Guo, Lixia Ma, Rui Liu, Zhonghua Fu, Fan Yang, Xiaoyan Ke, Kai Hu   +10 more
doaj   +1 more source