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Calcium binding by a myeloma protein [PDF]
The American Journal of Medicine, 1979 We describe a patient with immunoglobulin G (IgG)-kappa myeloma and severe, long-standing, asymptomatic hypercalcemia. Serum nonprotein-bound calcium concentration was 5.2 mg/dl (normal 4.2 to 5.0 mg/dl) at a time when total serum calcium concentration was 17.8 mg/dl.
Deane F. Mosher, Jeffrey P. Jaffe
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Plasma cell myeloma with D-myeloma protein (IgD myeloma)
The American Journal of Medicine, 1968Abstract Plasma cell myeloma distinguished by a serum D-myeloma protein has been found in many parts of the world and more than two dozen cases have been identified. Noteworthy observations are the high frequency (80 per cent) of D-myeloma protein with lambda-light chains (D-myeloma protein—type L) and the almost invariable presence of Bence Jones ...
Rolf Bachmann +3 more
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Biological Properties of Myeloma Proteins
Archives of Internal Medicine, 1975The paraproteins frequently cause major symptoms in patients with plasma cell dyscrasias. This may be due to their quantity in the circulation, to some unusual physicochemical property, or to a biological effect resulting in interaction with other serum proteins.
Espinoza Lr, Osterland Ck
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Intraneuronal Accumulation of Myeloma Proteins
Archives of Neurology, 1985We studied a patient with multiple myeloma who had immunologically identified myeloma light chain proteins within neurons projecting beyond the blood-brain barrier, but not within intrinsic neurons of the spinal cord, brain stem, and cerebral cortex. There was a possibility that these myeloma light chain proteins or their immunologically recognizable ...
Lawrence F. Borges, Neil A. Busis
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On the structure of some myeloma proteins
Immunochemistry, 1969Abstract Myeloma proteins are characterised by their electrophoretc homogeneity manifested by a sharp ‘myeloma band’ seen on pherograms. Extensive analytical work on amino acid seqeunce of these paraproteins has been reported [1–9]. HOwever, there seems to be no clear basis for differentiation between proteins synthesised by normal plasma cells and ...
Emidio Afonso, A. Affonson
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Globulin and myeloma: The structural characterization of γ-globulin and myeloma protein
Archives of Biochemistry and Biophysics, 1962Abstract α-, β-, M - and γ-Type myeloma proteins were obtained by electrophoretic separation, and each protein was characterized by its amino acid composition, molecular weight, optical rotation, and infrared spectrum. The peculiar optical rotatory behavior of α-, β-, and γ-myeloma protein indicated that these proteins are to be classified as γ ...
Hironao Momoi, Kazutomo Imahori
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Contribution of Inhibition of Protein Catabolism in Myeloma
The Cancer Journal, 2019AbstractMultiple myeloma (MM) is a cancer of plasma cells, characterized by abundant synthesis of monoclonal immunoglobulins and/or free light chains. Although MM remains incurable, median overall survival has considerably improved over the past 2 decades largely due to the introduction of novel agents, including proteasome inhibitors (PIs) and ...
Kenneth C. Anderson, Giada Bianchi
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An unusual tryptic cleavage of a myeloma protein
Immunochemistry, 1978Abstract Digestion of IgG† Zie with trypsin produced two fragments which differed from the characteristic tFab and tFc normally obtained from tryptic cleavage of IgG. These two unique fragments, designated t 1 and T s were isolated from a tryptic digest of IgG Zie by gel filtration in dissociating solvents.
G. E. Connell, C.A. Laschinger
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A Calcium Binding IgG Myeloma Protein
Scandinavian Journal of Haematology, 1980A calcium binding IgG was isolated and purified by column chromatography from serum of a myeloma patient with asymptomatic hypercalcaemia. The myeloma IgG, characterized as an IgG kappa, revealed a normal sized heavy chain (56000 dalton), and a light chain of 31000 dalton.
Gad Spira +3 more
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ANTIGEN‐BINDING MYELOMA PROTEINS IN MICE
Annals of the New York Academy of Sciences, 1971Publisher Summary The immunoglobulins are a large family of structurally related proteins secreted by plasma cells. Plasma cells are normally differentiated so that each cell is usually restricted to making immunoglobulin with only a single VL and VH region. This chapter reviews to the immunochemical propeities of the antigen-binding myeloma proteins
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