Results 291 to 300 of about 87,373 (338)
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Intraneuronal Accumulation of Myeloma Proteins
Archives of Neurology, 1985We studied a patient with multiple myeloma who had immunologically identified myeloma light chain proteins within neurons projecting beyond the blood-brain barrier, but not within intrinsic neurons of the spinal cord, brain stem, and cerebral cortex. There was a possibility that these myeloma light chain proteins or their immunologically recognizable ...
Lawrence F. Borges, Neil A. Busis
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Phosphate Binding by a Myeloma Protein
Acta Medica Scandinavica, 1987ABSTRACT. A patient with IgG kappa myeloma had markedly elevated serum phosphate concentrations but no clinical features of hyperphosphataemia. The hyperphosphataemia was due to a high phosphate per protein unit than normal IgG.
Lars Hortling +4 more
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On the structure of some myeloma proteins
Immunochemistry, 1969Abstract Myeloma proteins are characterised by their electrophoretc homogeneity manifested by a sharp ‘myeloma band’ seen on pherograms. Extensive analytical work on amino acid seqeunce of these paraproteins has been reported [1–9]. HOwever, there seems to be no clear basis for differentiation between proteins synthesised by normal plasma cells and ...
Emidio Afonso, A. Affonson
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Globulin and myeloma: The structural characterization of γ-globulin and myeloma protein
Archives of Biochemistry and Biophysics, 1962Abstract α-, β-, M - and γ-Type myeloma proteins were obtained by electrophoretic separation, and each protein was characterized by its amino acid composition, molecular weight, optical rotation, and infrared spectrum. The peculiar optical rotatory behavior of α-, β-, and γ-myeloma protein indicated that these proteins are to be classified as γ ...
Hironao Momoi, Kazutomo Imahori
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Contribution of Inhibition of Protein Catabolism in Myeloma
The Cancer Journal, 2019AbstractMultiple myeloma (MM) is a cancer of plasma cells, characterized by abundant synthesis of monoclonal immunoglobulins and/or free light chains. Although MM remains incurable, median overall survival has considerably improved over the past 2 decades largely due to the introduction of novel agents, including proteasome inhibitors (PIs) and ...
Kenneth C. Anderson, Giada Bianchi
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An unusual tryptic cleavage of a myeloma protein
Immunochemistry, 1978Abstract Digestion of IgG† Zie with trypsin produced two fragments which differed from the characteristic tFab and tFc normally obtained from tryptic cleavage of IgG. These two unique fragments, designated t 1 and T s were isolated from a tryptic digest of IgG Zie by gel filtration in dissociating solvents.
G. E. Connell, C.A. Laschinger
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A Calcium Binding IgG Myeloma Protein
Scandinavian Journal of Haematology, 1980A calcium binding IgG was isolated and purified by column chromatography from serum of a myeloma patient with asymptomatic hypercalcaemia. The myeloma IgG, characterized as an IgG kappa, revealed a normal sized heavy chain (56000 dalton), and a light chain of 31000 dalton.
Gad Spira +3 more
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ANTIGEN‐BINDING MYELOMA PROTEINS IN MICE
Annals of the New York Academy of Sciences, 1971Publisher Summary The immunoglobulins are a large family of structurally related proteins secreted by plasma cells. Plasma cells are normally differentiated so that each cell is usually restricted to making immunoglobulin with only a single VL and VH region. This chapter reviews to the immunochemical propeities of the antigen-binding myeloma proteins
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Proteins in multiple myeloma. VI. Cryoglobulins
Archives of Biochemistry and Biophysics, 1956Abstract Eight cryoglobulins (abnormal human plasma globulins that have diminished solubility in the cold) have been investigated by means of the analytical ultracentrifuge, electrophoresis, N-terminal amino acid analysis, and serological classification.
Aiko Miyake, Frank W. Putnam
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Biologic properties of E myeloma proteins
The American Journal of Medicine, 1971Abstract E myeloma protein PS (PS protein) from the serum of the second known patient (P.S.) with IgE myeloma was purified by DEAE-cellulose column chromatography and Sephadex ® G-200 gel filtration. The physicochemical properties of this protein were identical with those of E myeloma protein ND (ND protein) from the first patient with IgE myeloma ...
William D. Terry +5 more
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