This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo +5 more
wiley +1 more source
Author Response: NETosis Markers such as Citrullinated Histones Myeloperoxidase and Elastase should not be Recommended as Predictors of COVID-19 Severity. [PDF]
Kumar A.
europepmc +1 more source
Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics
ABSTRACT Ewing sarcoma is an undifferentiated small round cell sarcoma that most commonly presents as a malignant bone tumor in pediatric and young adult patients. The diagnosis is typically confirmed by molecular genetic identification of a fusion protein, most commonly involving members of the FET and ETS gene families.
Jessica L. Muldoon +3 more
wiley +1 more source
Characterization of Circulating Immune Complexes in Patients with Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis. [PDF]
Oda T +8 more
europepmc +1 more source
S1 Guideline: Therapy of generalized pustular psoriasis
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner +17 more
wiley +1 more source
Paraneoplastic Myeloperoxidase (MPO)-Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Revealing Colon Adenocarcinoma in a Patient With Controlled HIV Infection: A Case Report. [PDF]
Cespedes Useche LP +4 more
europepmc +1 more source
Management Dilemma: Myeloperoxidase (MPO)-Positive Vasculitis in a Patient With Metastatic Malignant Melanoma. [PDF]
Sajjad A, Manivannan A.
europepmc +1 more source
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
The role of parasite-derived vesicles in modulating neutrophil responses in emerging human babesiosis. [PDF]
Haak S +3 more
europepmc +1 more source
Neutrophil extracellular traps formation is associated with impaired clot retraction and fibrinolysis in asthma. [PDF]
Misztal T +5 more
europepmc +1 more source

