Results 351 to 360 of about 146,491 (388)
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The development of myeloperoxidase inhibitors.
Bioorganic & Medicinal Chemistry Letters, 2019Myeloperoxidase (MPO), an abundant hemoprotein present in neutrophils and monocytes, plays a significant role in immune surveillance and host defense mechanisms. However, increased MPO activity has been linked to a number of pathologies with compelling evidence in initiation and progression of inflammatory events.
S. Galijašević
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Current Opinion in Hematology, 2000
This review covers recent advances in the biology of myeloperoxidase. Mechanisms of posttranslational processing and how these fail in some of the common deficiency mutants are discussed. We also review the enzymology that points to myeloperoxidase having a number of physiologic substrates in addition to chloride and the evidence that it produces ...
C C, Winterbourn +2 more
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This review covers recent advances in the biology of myeloperoxidase. Mechanisms of posttranslational processing and how these fail in some of the common deficiency mutants are discussed. We also review the enzymology that points to myeloperoxidase having a number of physiologic substrates in addition to chloride and the evidence that it produces ...
C C, Winterbourn +2 more
openaire +2 more sources
The glycosylation of myeloperoxidase
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010The enzyme myeloperoxidase (MPO) is an important part of the neutrophil immune reaction and can be found in alfa granula. The presence of MPO can be used to distinguish acute myelogenous leukemia from acute lymphocytic leukemia. However, the methods employed to do so, such as flow cytometry and immunohistochemistry rely on antibody recognition, and ...
Ravnsborg, Tina +2 more
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2020
Myeloperoxidase participates in innate immune defense mechanism through formation of microbicidal reactive oxidants and diffusible radical species. A unique activity is its ability to use chloride as a cosubstrate with hydrogen peroxide to generate chlorinating oxidants such as hypochlorous acid, a potent antimicrobial agent.
François Dufrasne +3 more
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Myeloperoxidase participates in innate immune defense mechanism through formation of microbicidal reactive oxidants and diffusible radical species. A unique activity is its ability to use chloride as a cosubstrate with hydrogen peroxide to generate chlorinating oxidants such as hypochlorous acid, a potent antimicrobial agent.
François Dufrasne +3 more
openaire +3 more sources
Human Immunology, 2012
In the current study, whether myeloperoxidase (MPO)-catalyzing reaction could influence the antigenicity of MPO was investigated. Hypochlorite acid, the main product of the catalytic reaction, could lower the binding between MPO-antineutrophil cytoplasmic antibodies (ANCA) and MPO when the available chlorine was higher than 0.031×10(-3) g/l.
Peng-Cheng Xu +4 more
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In the current study, whether myeloperoxidase (MPO)-catalyzing reaction could influence the antigenicity of MPO was investigated. Hypochlorite acid, the main product of the catalytic reaction, could lower the binding between MPO-antineutrophil cytoplasmic antibodies (ANCA) and MPO when the available chlorine was higher than 0.031×10(-3) g/l.
Peng-Cheng Xu +4 more
openaire +3 more sources
Circulating Myeloperoxidase and Anti-Myeloperoxidase Antibody in Patients with Vasculitis
Scandinavian Journal of Rheumatology, 1999To evaluate a role of myeloperoxidase (MPO) and antibody to myeloperoxidase (anti-MPO) in vasculitis, MPO and anti-MPO were determined by enzyme-linked immunosorbent assays in sera from 43 patients with vasculitis, 40 with rheumatoid arthritis, 36 with systemic lupus erythematosus (SLE), 23 with mixed connective tissue disease, 13 with systemic ...
Shogo Kano +7 more
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Proceedings of the Association of American Physicians, 1999
Phagocytes respond to stimulation with a burst of oxygen consumption, and much, if not all, of the extra oxygen consumed in the respiratory burst is converted first to the superoxide anion and then to hydrogen peroxide (H2O2). Myeloperoxidase (MPO), which is released from cytoplasmic granules of neutrophils and monocytes by a degranulation process ...
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Phagocytes respond to stimulation with a burst of oxygen consumption, and much, if not all, of the extra oxygen consumed in the respiratory burst is converted first to the superoxide anion and then to hydrogen peroxide (H2O2). Myeloperoxidase (MPO), which is released from cytoplasmic granules of neutrophils and monocytes by a degranulation process ...
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Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.
Blood, 1998IN THE 1880s Elie Metchnikoff observed specialized phagocytic cells ingesting bacteria, and recognized the importance of phagocytosis as a defense mechanism in multicellular organisms.[1][1] Neutrophils are one of the professional phagocytes in humans ...
M. Hampton, A. Kettle, C. Winterbourn
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Hematology/Oncology Clinics of North America, 1988
MPO activity is critical for optimal microbicidal activity of normal PMNs. In the absence of MPO, auxiliary mechanisms protect most MPO-deficient hosts from clinically significant sequelae, except for some persons with diabetes mellitus who suffer severe candidal disease.
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MPO activity is critical for optimal microbicidal activity of normal PMNs. In the absence of MPO, auxiliary mechanisms protect most MPO-deficient hosts from clinically significant sequelae, except for some persons with diabetes mellitus who suffer severe candidal disease.
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Endothelium, Myeloperoxidase, Anti-Myeloperoxidase Interaction in Vasculitis
1993Antibodies to myeloperoxidase (MPO) are found in the sera of patients with microscopic polyarteritis and idiopathic crescentic glomerulonephritis. Their pathogenicity is unknown. Studies were carried out on the binding of MPO to cultured human umbilical vein endothelial cells and the recognition of endothelium-bound MPO by antibody to MPO.
J. Michael +6 more
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