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Myeloperoxidase and Neurological Disorder: A Crosstalk.
ACS Chemical Neuroscience, 2018Myeloperoxidase (MPO) is a protein present in azurophilic granules, macrophages, and neutrophils that are released into extracellular fluid (ECF) during inflammation. MPO releases hypochlorous acid (HOCl) and other chlorinated species. It is derived from
K. Pravalika +9 more
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[20] Human myeloperoxidase and hemi-myeloperoxidase
1986Publisher Summary This chapter describes human myeloperoxidase (MPO) and hemi-MPO. MPO is an enzyme found in the azurophilic granules of mammalian neutrophils and is also identified in human monocytes. Its function is to kill bacteria that have been phagocytosed by these cells.
Patricia C. Andrews, Norman I. Krinsky
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Neuromediated Myeloperoxidase Deficiency
Archives of Pediatrics & Adolescent Medicine, 1990Sir.—In the March 1925 issue ofAJDC, Sato1reported changes in the blood myeloid leukocytes, resulting from injuries to certain parts of the brain produced experimentally in animals. Only those rabbits that had received bilateral thermocautery lesions of the corpora striata showed a myeloperoxidase (MPO)–negative reaction of neutrophils in fresh blood ...
Cesare Cocchi, P. Cocchi
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Diagnostic Assays for Myeloperoxidase and Myeloperoxidase Deficiency
2014Neutrophils (PMN) represent the dominant cell in the acute response to microbial infection and can contribute to some of the tissue damage that accompanies sterile inflammation. Effective antimicrobial activity in neutrophil phagosomes reflects the combined action of soluble agents in plasma with PMN-derived reactive oxygen species and granule proteins,
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Role of Myeloperoxidase in Cardiology
Future Cardiology, 2010Myeloperoxidase (MPO) is an enzyme found in myeloid cells, particularly in neutrophils, and to a lesser extent in monocytes and tissue macrophages. MPO plays an important role in the host defense against bacteria and viruses. Since MPO is also an important enzyme in the inflammatory process, and inflammation is a key component in the development and ...
Baris Ikitimur, Bilgehan Karadag
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Partial Myeloperoxidase Deficiency
Acta Haematologica, 1982Neutrophil myeloperoxidase (MPO) activity was analyzed by a semi-quantitative cytochemical method in 268 subjects divided into several groups. 17 subjects with significantly reduced MPO activity were found: 11 of 23 in the preleukemia group, 2/14 AMLs, 1/20 myeloproliferative syndrome, 1/7 carcinoma with bone marrow metastases, 1/33 diabetes mellitus ...
Fedor Bachmann +2 more
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Biochemical and Biophysical Research Communications, 1980
Summary The optical spectrum of the primary peroxide compound of myeloperoxidase (compound I) is reported. The spectrum, obtained in 1 msec after mixing native ferric myeloperoxidase with excess hydrogen peroxide, exhibits a Soret maximum at 425 nm (c = 52 mM−1 cm−1) and an increase in extinction of the ferric peroxidase at wavelengths higher than ...
Tsunehisa Araiso +3 more
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Summary The optical spectrum of the primary peroxide compound of myeloperoxidase (compound I) is reported. The spectrum, obtained in 1 msec after mixing native ferric myeloperoxidase with excess hydrogen peroxide, exhibits a Soret maximum at 425 nm (c = 52 mM−1 cm−1) and an increase in extinction of the ferric peroxidase at wavelengths higher than ...
Tsunehisa Araiso +3 more
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Myeloperoxidase and Atherosclerosis
Current Cardiovascular Risk Reports, 2013Myeloperoxidase (MPO), a member of the peroxidase family, emerged as a major player in the initiation and propagation of atherosclerotic cardiovascular disease (CVD). Evidence for its role in atherosclerosis include that MPO: a) induces endothelial dysfunction, b) modifies physiologically functional high density lipoprotein (HDL) into “dysfunctional ...
Vaijinath S. Kamanna +4 more
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Neutrophil activation in response to monomeric myeloperoxidase.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 2018Myeloperoxidase (MPO) is an oxidant-producing enzyme that can also regulate cellular functions via its nonenzymatic effects. Mature active MPO isolated from normal human neutrophils is a 145 kDa homodimer, which consists of 2 identical protomers ...
I. V. Gorudko +9 more
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Myeloperoxidase in Cardiovascular Disease
2013Myeloperoxidase (MPO) plays a central role in the innate immune system by generating leukocyte-derived oxidants to combat invading pathogens. These reactive intermediates have been increasingly recognized to be potentially deleterious, causing oxidative injury in inflammatory disease states such as cardiovascular disease.
Virginia N. Haselden +3 more
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