Results 111 to 120 of about 3,006,184 (303)

A mutação JAK2 V617F e as síndromes mieloproliferativas JAK2 V617F mutation and the myeloproliferative disorders

Revista Brasileira de Hematologia e Hemoterapia, 2008
Síndromes mieloproliferativas (SMPs) são doenças hematopoéticas de origem clonal que apresentam amplificação de uma ou mais linhagens mielóides. Policitemia vera (PV), trombocitemia essencial (TE), mielofibrose idiopática (MF) e leucemia mielóide crônica
Bárbara C. R. Monte-Mór, Fernando F. Costa   +1 more
doaj   +1 more source

Glucose‐6‐phosphate dehydrogenase deficiency is associated with improved survival in patients with acute myeloid leukemia treated with venetoclax and azacitidine

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency impairs cellular redox balance through reduced NADPH production and is the most common enzymatic disorder‐causing anemia. Venetoclax combined with azacitidine (Ven‐Aza) targets leukemic stem cells by disrupting oxidative phosphorylation and inducing mitochondrial stress. This study
Shira Buchrits, Alon Rozental, Noa Korngold, Ofer Algor, Shirly Partouche, Galit Granot, Pia Raanani, Ofir Wolach   +7 more
wiley   +1 more source

The use of genetic tests to diagnose and manage patients with myeloproliferative and myeloproliferative/myelodysplastic neoplasms, and related disorders [PDF]

, 2021
Nicholas C.P. Cross, Anna L. Godfrey, Catherine Cargo, Mamta Garg, Adam J. Mead, A British Society for Haematology Good Practice Paper   +5 more
openalex   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Myeloproliferative disorders and its associated mutations

Research in Molecular Medicine, 2014
Myeloproliferative Neoplasm (MPN) are a clonal disorder in hematopoietic stem cells (HSC). MPN is categorized to 8 subclasses, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocytopenia (ET), primary myelofibrosis (PMF),
Kaveh Tari, Reza Yarahmadi, Amir Tabatabaei, Fakhredin Saba, Saeid Abroun, Amir Atashi, Masoud Soleimani   +6 more
doaj  

Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia

Case Reports in Hematology, 2016
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation.
Stephen E. Langabeer, Karl Haslam, David O’Brien, Johanna Kelly, Claire Andrews, Ciara Ryan, Richard Flavin, Patrick J. Hayden, Christopher L. Bacon   +8 more
doaj   +1 more source

De novo appearance of the ph-1 chromosome in a previously monosomic bone marrow (45,XX,-6): conversion of a myeloproliferative disorder to acute myelogenous leukemia [PDF]

, 1975
G Kohn, N Manny, A Eldor, MM Cohen
openalex   +1 more source

Increased Skeletal Muscle Fat in Patients With Haematological Cancer Is Associated With Reduced Cardiorespiratory Fitness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Patients with haematological cancer often exhibit reduced cardiorespiratory fitness and an elevated risk of cardiovascular disease. The mechanisms underlying this impairment are multifactorial, but the contribution of skeletal muscle fat infiltration has not been evaluated.
Nicholas J. Saner, Stephen J. Foulkes, Hayley T. Dillon, Lauren Burnham, Richard Thompson, Andre La Gerche, Mark J. Haykowsky, Erin J. Howden   +7 more
wiley   +1 more source

Prevalence and clinical significance of sarcopenia in patients with chronic myeloproliferative neoplasms: epidemiology, diagnosis, and intervention strategies

КардиоСоматика
Chronic myeloproliferative neoplasms (MPNs) are a group of clonal hematopoietic disorders that predominantly affect older patients. These conditions are associated with increased risk of numerous complications.
Adelina G. Garifullina, Bulat A. Bakirov, Gulnaz H. Lasynova, Evgeny O. Goldyrev, Dmitry A. Kudlay   +4 more
doaj   +1 more source

MYELODYSPLASTIC/MYELOPROLIFERATIVE DISEASES

Онкогематология, 2017
Chronic myeloid malignancies that have characteristics of both the myelodysplastic and myeloproliferative disorders allocated to myelodysplastic/myeloproliferative diseases (MDS/MPD) group in 2008 World Health Organization classification.
I. N. Subortseva, A. I. Melikyan
doaj   +1 more source