Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders - Epidemiological Features and Overview. [PDF]
Front Oncol, 2021 Kuendgen A, Kasprzak A, Germing U.
europepmc +1 more source
The Myeloproliferative Disorders With Special Reference to Myelofibrosis [PDF]
, 1953 M. S. R. Hutt +2 more
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Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Allogeneic Hematopoietic Stem Cell Transplantation for Mixed or Overlap Myelodysplastic/Myeloproliferative Disorders. [PDF]
Front Oncol, 2022 Symeonidis A +5 more
europepmc +1 more source
DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source
Clonal Myeloproliferative Disorders in Patients with Down Syndrome-Treatment and Outcome Results from an Institution in Argentina. [PDF]
Cancers (Basel), 2022 Pennella CL +10 more
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HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.HOXB4 is overexpressed in bladder cancer and associated with poor prognosis. By transcriptionally activating Smoothened (SMO), HOXB4 amplifies SMO–GLI signaling to promote tumor growth and metastatic behavior. This graphical abstract highlights the HOXB4–SMO axis as a key driver of bladder cancer progression and a potential target for future ...
Zhaoheng Jin +6 more
wiley +1 more source
Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders. [PDF]
Stem Cell Rev Rep, 2023 Janus T +6 more
europepmc +1 more source
Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment
Cancer Medicine, Volume 15, Issue 1, January 2026.Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang +5 more
wiley +1 more source