Results 21 to 30 of about 94,073 (238)
Genomics of Myeloproliferative Neoplasms [PDF]
Journal of Clinical Oncology, 2017 Myeloproliferative neoplasms (MPNs) are a group of related clonal hematologic disorders characterized by excess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myeloid leukemia. Deregulated JAK2 signaling has emerged as the central phenotypic driver of BCR -ABL1–negative MPNs and a unifying therapeutic target. In
Zoi, Katerina, Cross, Nicholas
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Epigenetics in myeloproliferative neoplasms
Frontiers in Oncology, 2023 The myeloproliferative neoplasms (MPNs) are a group of acquired clonal disorders where mutations drive proliferative disease resulting in increased blood counts and in some cases end-stage myelofibrosis. Epigenetic changes are the reversible modifications to DNA- and RNA-associated proteins that impact gene activity without changing the DNA sequence ...
Greenfield, Graeme +1 more
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Genetics of Myeloproliferative Neoplasms [PDF]
The Cancer Journal, 2014 In the last decade, genomic studies have identified multiple recurrent somatic mutations in myeloproliferative neoplasms (MPNs). Beginning with the discovery of the JAK2 V617F mutation, multiple additional mutations have been found that constitutively activate cell-signaling pathways, including MPL, CBL, and LNK.
Aaron D, Viny, Ross L, Levine
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Unbalanced rearrangement, der(9;18)(p10;q10) in a patient with myeloproliferative neoplasm. Case 0001M. [PDF]
, 2011 Case report of a translocation : Unbalanced rearrangement, der(9;18)(p10;q10) in a patient with myeloproliferative neoplasm. Case 0001M.
Reddy, KS
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A CASE OF HEADACHE TURNING INTO MYELOPROLIFERATIVE NEOPLASM-A CASE REPORT
, 2023 <p>Headache is an important clinical symptom commonly encountered by practising physicians. Thorough history and physical examination is a must for arriving at differentials of headache.
Sreeraj H.
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Update in the myeloproliferative neoplasms [PDF]
Clinical Medicine, 2014 The differential diagnosis of haematological abnormalities, such as leucocytosis, erythocytosis, thrombocytosis or indeed anaemia, is wide and disarming. Here we report on significant updates in the differential diagnosis of erythrocyosis and thrombocytosis presenting a simplified schema for the clinician.
Harrison, Claire N, McMullin, Mary F
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, 2022 . A middle-aged man was diagnosed with myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U), with severe and extensive corticosteroid-resistant Sweet’s syndrome (SS) as the first manifestation, with evidence of clinical manifestations ...
Chuanli Zhao +9 more
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Genetics of Myeloproliferative Neoplasms
Hematology/Oncology Clinics of North America, 2021 Myeloproliferative neoplasms are hematopoietic stem cell disorders based on somatic mutations in JAK2, calreticulin, or MPL activating JAK-STAT signaling. Modern sequencing efforts have revealed the genomic landscape of myeloproliferative neoplasms with additional genetic alterations mainly in epigenetic modifiers and splicing factors.
Jakub, Szybinski, Sara C, Meyer
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Aetiology of Myeloproliferative Neoplasms [PDF]
Cancers, 2020 Myeloproliferative neoplasms (MPNs) have estimated annual incidence rates for polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis of 0.84, 1.03, and 0.47 per 100,000. Prevalence is much higher, particularly for PV and ET, as mortality rates are relatively low.
Mary Frances McMullin +1 more
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Extracranial carotid artery aneurysm with myeloproliferative neoplastic cell invasion
Journal of Vascular Surgery Cases and Innovative Techniques, 2020 The major causes of rare extracranial carotid artery aneurysms are arteriosclerosis, trauma, and radiation therapy. Here, we describe a patient with an extracranial carotid artery aneurysm caused by a myeloproliferative neoplasm.
Shotaro Ogawa, MD +2 more
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