Results 21 to 30 of about 28,496 (220)

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow

Haematologica, 2012
We investigated 15,542 patients with suspected BCR-ABL1- negative myeloproliferative or myelodysplastic/myeloproliferative neoplasm (including 359 chronic myelomonocytic leukemia) by a molecular marker set.
Susanne Schnittger, Ulrike Bacher, Christiane Eder, Frank Dicker, Tamara Alpermann, Vera Grossmann, Alexander Kohlmann, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach   +9 more
doaj   +1 more source

Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: a nationwide discovery cohort

Haematologica, 2019
Myeloid and lymphoid malignancies are postulated to have distinct pathogenetic mechanisms. The recent observation that patients with a myeloproliferative neoplasm have an increased risk of developing lymphoproliferative malignancy has challenged this ...
Johanne M. Holst, Trine L. Plesner, Martin B. Pedersen, Henrik Frederiksen, Michael B. Møller, Michael R. Clausen, Marcus C. Hansen, Stephen Jacques Hamilton-Dutoit, Peter Nørgaard, Preben Johansen, Tobias Ramm Eberlein, Bo K. Mortensen, Gustav Mathiasen, Andreas Øvlisen, Rui Wang, Chao Wang, Weiwei Zhang, Hans Beier Ommen, Jesper Stentoft, Maja Ludvigsen, Wayne Tam, Wing C. Chan, Giorgio Inghirami, Francesco d'Amore   +23 more
doaj   +1 more source

Epigenetics in Myeloproliferative Neoplasms [PDF]

Journal of Cellular and Molecular Medicine, 2017
AbstractA decade on from the description of JAK2 V617F, the MPNs are circumscribed by an increasingly intricate landscape. There is now evidence that they are likely the result of combined genetic dysregulation, with several mutated genes involved in the regulation of epigenetic mechanisms. Epigenetic changes are not due to a change in the DNA sequence
Suzanne McPherson, Mary Frances McMullin, Ken Mills   +2 more
openaire   +3 more sources

JAK2 rs10974944 is associated with both V617F‐positive and negative myeloproliferative neoplasms in a Vietnamese population: A potential genetic marker

Molecular Genetics & Genomic Medicine, 2022
The JAK2 gene encodes for a non‐receptor tyrosine kinase that plays a key role in the JAK/STAT signaling transfer pathway. Genetic polymorphisms of this gene have been indicated to be associated with myeloproliferative neoplasm‐associated thrombosis in ...
Nguyen Thy Ngoc, Bui Bich Hau, Nguyen Ba Vuong, Nguyen Thi Xuan   +3 more
doaj   +1 more source

Myelodysplastic/Myeloproliferative Neoplasms [PDF]

American Journal of Clinical Pathology, 2009
AbstractMyelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are rare de novo myeloid neoplasms that exhibit hybrid dysplastic and proliferative features at presentation. This SHP/EAHP Workshop session was uniquely problematic owing to the overlap between MDS/MPNs and both chronic myeloproliferative neoplasms and myelodysplasia.
openaire   +2 more sources

Autoimmunity and the risk of myeloproliferative neoplasms

Haematologica, 2010
The causes of myeloproliferative neoplasm (MPN) are unknown. We conducted a large population-based study including 11,039 myeloproliferative neoplasm patients and 43,550 matched controls with the aim of assessing the associations between a personal ...
Sigurdur Y. Kristinsson, Ola Landgren, Jan Samuelsson, Magnus Björkholm, Lynn R. Goldin   +4 more
doaj   +1 more source

Molecular approach to diagnose BCR/ABL negative chronic myeloproliferative neoplasms

Revista Brasileira de Hematologia e Hemoterapia, 2011
Chronic myeloproliferative neoplasms arise from clonal proliferation of hematopoietic stem cells. According to the World Health Organization myeloproliferative neoplasms are classified as: chronic myelogenous leukemia, polycythemia vera, essential ...
Michelle Maccarini Barcelos, Maria Cláudia Santos-Silva   +1 more
doaj   +1 more source

Neutrophilic Dermatosis of the Dorsal Hands Associated with a “Myeloproliferative Neoplasm, Unclassifiable“ and a Simultaneous Cancer of Colon

Acta Medica, 2010
Neutrophilic dermatosis of the dorsal hands is a variant of Sweet's syndrome. We herein describe an 83-year old woman with a neutrophilic dermatosis of the dorsal hands associated with a "myeloproliferative neoplasm, unclassifiable" and a simultaneous ...
Francisco José Fernández-Fernández, Juan Carlos Álvarez – Fernández, Esperanza Romero – Picos, Juan Antonio Garrido, Pascual Sesma   +4 more
doaj   +1 more source

Outgrowth of a CSF3R-mutant clone drives a second myeloproliferative neoplasm in a chronic myeloid leukemia patient: a case report

Biomarker Research, 2021
Background Chronic myeloid leukemia (CML) and chronic neutrophilic leukemia (CNL) are two myeloproliferative neoplasms with mutually exclusive diagnostic criteria.
Sarah A. Carratt, Diana Brewer, Julia E. Maxson, Brian J. Druker, Theodore P. Braun   +4 more
doaj   +1 more source

Breakthroughs in myeloproliferative neoplasms

Hematology, 2012
The discovery of the JAK2V617F mutation ushered the field of Philadelphia-negative myeloproliferative neoplasms (MPNs) into the era of targeted therapy. Currently, there are several JAK2 inhibitors in clinical trials for patients with MPNs, particularly for patients with myelofibrosis (MF).
Fabio P S, Santos, Srdan, Verstovsek
openaire   +2 more sources